Firmagon Side Effects
Generic name: degarelix
Medically reviewed by Drugs.com. Last updated on Oct 6, 2023.
Note: This document contains side effect information about degarelix. Some dosage forms listed on this page may not apply to the brand name Firmagon.
Applies to degarelix: subcutaneous powder for solution.
Serious side effects of Firmagon
Along with its needed effects, degarelix (the active ingredient contained in Firmagon) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking degarelix:
More common
- Back pain
- blurred vision
- dizziness
- fever
- flushing or redness of the skin
- hard lump
- headache
- nervousness
- pain
- pounding in the ears
- slow or fast heartbeat
- small lumps under the skin
- swelling
- unusually warm skin
Less common
- Bladder pain
- bloody or cloudy urine
- chills
- decrease in testicle size
- decreased interest in sexual intercourse
- difficult, burning, or painful urination
- difficulty in moving
- frequent urge to urinate
- inability to have or keep an erection
- increased sweating
- loss in sexual ability, desire, drive, or performance
- lower back or side pain
- muscle pain or stiffness
- pain in the joints
Rare
- Chest pain or discomfort
- fainting
- irregular heartbeat
- pounding heartbeat
Incidence not known
- Cough
- difficulty swallowing
- hives, itching, or skin rash
- puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
- tightness in the chest
- trouble breathing
- unusual tiredness or weakness
Other side effects of Firmagon
Some side effects of degarelix may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Difficulty having a bowel movement (stool)
- feeling of warmth
- increased weight
- redness of the face, neck, arms, and occasionally, upper chest
- sudden sweating
Less common
- Diarrhea
- lack or loss of strength
- nausea
- night sweats
- swelling of the breasts or breast soreness
- trouble sleeping
For Healthcare Professionals
Applies to degarelix: subcutaneous powder for injection.
Hepatic
Very common (10% or more): Increased liver transaminases (47%), increased gamma-glutamyltransferase (10%)
Uncommon (0.1% to 1%): Increased bilirubin, increased alkaline phosphatase[Ref]
Other
Very common (10% or more): Injection site reaction (including pain, erythema, swelling, induration, nodule; 44%), pyrexia (10%), fatigue (10%)
Common (1% to 10%): Chills, asthenia, influenza-like illness[Ref]
Hematologic
Very common (10% or more): Decreased hematocrit (40%), decreased hemoglobin (15%)
Common (1% to 10%): Anemia
Rare (less than 0.1%): Neutropenic fever[Ref]
Cardiovascular
Very common (10% or more): Hot flush (26%), QT/QTc interval prolongation (20%)
Common (1% to 10%): Hypertension
Uncommon (0.1% to 1%): Cardiac arrhythmia (including atrial fibrillation), palpitations, vasovagal reaction (including hypotension)
Rare (less than 0.1%): Myocardial infarction, cardiac failure[Ref]
Renal
Very common (10% or more): Abnormal BUN (15%)
Common (1% to 10%): Abnormal creatinine level
Uncommon (0.1% to 1%): Renal impairment[Ref]
Metabolic
Very common (10% or more): Increased weight (11%), decreased weight (10%)
Common (1% to 10%): Abnormal potassium level
Uncommon (0.1% to 1%): Hyperglycemia/diabetes mellitus, increased cholesterol, decreased appetite, blood calcium changes[Ref]
Immunologic
Very common (10% or more): Antibody formation (10%)[Ref]
Dermatologic
Common (1% to 10%): Hyperhidrosis (including night sweats), rash
Uncommon (0.1% to 1%): Urticaria, skin hyperpigmentation, skin nodule, alopecia, pruritus, erythema[Ref]
Gastrointestinal
Common (1% to 10%): Nausea, constipation, diarrhea
Uncommon (0.1% to 1%): Vomiting, abdominal pain, abdominal discomfort, dry mouth[Ref]
Genitourinary
Common (1% to 10%): Urinary tract infection, gynecomastia, testicular atrophy, erectile dysfunction
Uncommon (0.1% to 1%): Pollakiuria, micturition urgency, dysuria, nocturia, incontinence, testicular pain, breast pain, pelvic pain, genital irritation, ejaculation failure[Ref]
Musculoskeletal
Common (1% to 10%): Back pain, arthralgia, musculoskeletal pain and discomfort
Uncommon (0.1% to 1%): Osteoporosis/osteopenia, arthralgia, muscular weakness, muscle spasms, joint swelling/stiffness[Ref]
Nervous system
Common (1% to 10%): Dizziness, headache
Uncommon (0.1% to 1%): Mental impairment, hypoesthesia[Ref]
Psychiatric
Common (1% to 10%): Insomnia
Uncommon (0.1% to 1%): Loss of/decreased libido, depression[Ref]
Hypersensitivity
Uncommon (0.1% to 1%): Hypersensitivity reaction
Postmarketing reports: Anaphylaxis, angioedema[Ref]
Ocular
Uncommon (0.1% to 1%): Blurred vision[Ref]
Respiratory
Uncommon (0.1% to 1%): Dyspnea[Ref]
Frequently asked questions
More about Firmagon (degarelix)
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- During pregnancy
- FDA approval history
- Drug class: gonadotropin-releasing hormone antagonists
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Related treatment guides
References
1. Cerner Multum, Inc. UK Summary of Product Characteristics.
2. Cerner Multum, Inc. Australian Product Information.
3. Product Information. Firmagon (degarelix). Ferring Pharmaceuticals Inc. 2013.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.