Exenatide Side Effects

Some side effects of exenatide may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to exenatide: subcutaneous solution

Get emergency medical help if you have any of these signs of an allergic reaction while taking exenatide: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using exenatide and call your doctor at once if you have a serious side effect such as:

• swelling, weight gain, feeling short of breath, urinating less than usual or not at all;

• drowsiness, confusion, mood changes, increased thirst, diarrhea;

• dull pain in your middle or lower back;

• severe pain in your upper stomach spreading to your back, vomiting; or

• low blood sugar (headache, hunger, weakness, sweating, confusion, irritability, dizziness, fast heart rate, or feeling jittery).

Less serious side effects of exenatide may include:

• nausea, upset stomach, diarrhea or constipation;

• weight loss; or

• loss of appetite.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to exenatide: subcutaneous powder for injection extended release, subcutaneous solution

Metabolic

Metabolic side effects have included hypoglycemia.

Most episodes of hypoglycemia were mild to moderate in intensity and all resolved with administration of carbohydrate. Hypoglycemia was rarely observed in patients treated with the combination of exenatide and metformin and was similar in incidence to patients treated with placebo and metformin. When used as add-on to a thiazolidinedione, with or without metformin, the incidence of symptomatic mild to moderate hypoglycemia with exenatide was 11% compared to 7% with placebo.

Gastrointestinal

Gastrointestinal side effects have included nausea, vomiting, diarrhea, and dyspepsia.

Nervous system

Nervous system side effects have included dizziness, headache and feeling jittery.

Immunologic

Immunologic side effects have included the development of anti exenatide antibodies.

Dermatologic

Dermatologic side effects have included postmarketing reports of alopecia.

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