Exenatide Side Effects
Not all side effects for exenatide may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
For the Consumer
Applies to exenatide: subcutaneous powder for suspension extended release, subcutaneous solution
In addition to its needed effects, some unwanted effects may be caused by exenatide. In the event that any of these side effects do occur, they may require medical attention.
You should check with your doctor immediately if any of these side effects occur when taking exenatide:Incidence not known
- bloated or full feeling
- darkened urine
- decreased urination or urine output
- difficulty with swallowing
- dry mouth
- fast heartbeat
- hives or welts
- increase in heart rate
- itching skin
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- loss of appetite
- muscle twitching
- pains in the stomach, side, or abdomen, possibly radiating to the back
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- rapid breathing
- rapid weight gain
- shortness of breath
- skin rash
- sunken eyes
- swelling of the face, ankles, or hands
- tightness in the chest
- unusual tiredness or weakness
- wrinkled skin
- yellow eyes or skin
If any of the following symptoms of overdose occur while taking exenatide, get emergency help immediately:Symptoms of overdose
- blurred vision
- cold sweats
- cool, pale skin
- increased hunger
- severe vomiting
- slurred speech
Some of the side effects that can occur with exenatide may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:More common
- Acid or sour stomach
- feeling jittery
- stomach discomfort or upset
- Appetite decreased
- increased sweating
- lack or loss of strength
- Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
- change in taste
- excess air or gas in the stomach or intestines
- loss of taste
- passing gas
- pressure in the stomach
- rash with flat lesions or small raised lesions on the skin
- redness of the skin
- sleepiness or unusual drowsiness
- swelling of the abdomen or stomach area
For Healthcare Professionals
Applies to exenatide: subcutaneous powder for injection extended release, subcutaneous solution
Metabolic side effects have included hypoglycemia.
Most episodes of hypoglycemia were mild to moderate in intensity and all resolved with administration of carbohydrate. Hypoglycemia was rarely observed in patients treated with the combination of exenatide and metformin and was similar in incidence to patients treated with placebo and metformin. When used as add-on to a thiazolidinedione, with or without metformin, the incidence of symptomatic mild to moderate hypoglycemia with exenatide was 11% compared to 7% with placebo.
Gastrointestinal side effects have included nausea, vomiting, diarrhea, and dyspepsia.
Nervous system side effects have included dizziness, headache and feeling jittery.
Immunologic side effects have included the development of anti exenatide antibodies.
Dermatologic side effects have included postmarketing reports of alopecia.
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