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Exenatide Dosage

Medically reviewed by Drugs.com. Last updated on Aug 7, 2023.

Applies to the following strengths: 5 mcg/0.02 mL; 2 mg; 10 mcg/0.04 mL; 2 mg/0.85 mL

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Diabetes Type 2

Immediate-release (Byetta):
Initial dose: 5 mcg subcutaneously twice a day within the 60-minute period before the morning and evening meals


Extended-release (Bydureon; Bydureon BCISE):
Initial dose: 2 mg subcutaneously once every 7 days (weekly)

Comments:

Use: As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Usual Pediatric Dose for Diabetes Type 2

10 years and older:
Extended-release (Bydureon; Bydureon BCISE): 2 mg subcutaneously once every 7 days (weekly)


Comments:

Use: As an adjunct to diet and exercise to improve glycemic control in pediatric patients 10 years and older with type 2 diabetes mellitus.

Renal Dose Adjustments

Immediate-release (Byetta):


Extended-release (Bydureon; Bydureon BCISE):

Renal transplantation: Use with caution; closely monitor for adverse reactions that may lead to hypovolemia

Liver Dose Adjustments

No adjustment recommended

Dose Adjustments

Elderly: Use caution when initiating therapy as elderly patients are more likely to have decreased renal function.

Concomitant use with Insulin or Insulin Secretagogues (e.g. sulfonylureas)


Missed doses:
Immediate-release:

Extended-release:
Changing Administration Day:

Precautions

US BOXED WARNINGS: RISK OF THYROID C-CELL TUMORS (extended-release formulations)


CONTRAINDICATIONS:

Safety and efficacy have not been established in patients younger than 18 years (immediate-release).
Safety and efficacy have not been established in patients younger than 10 years (extended-release).

Consult WARNINGS section for additional precautions.

Dialysis

Not recommended in patients with ESRD

Other Comments

Administration advice:


IMMEDIATE-RELEASE (Byetta):

EXTENDED-RELEASE (Bydureon; Bydureon BCISE):

Storage requirements: Protect from light; do not freeze (discard if frozen)

Reconstitution/Preparation Techniques:

General:

Monitoring:

Patient advice:

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.