Exenatide Dosage

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Diabetes Type 2

subcutaneous solution:
5 micrograms subcutaneously twice daily within the 60 minute period before the morning and evening meals. Exenatide should not be administered after a meal. Based on clinical response, the dose can be increased to 10 micrograms twice daily after 1 month of therapy.

subcutaneous powder for injection, extended release:
2 mg subcutaneously once every seven days (weekly), at any time of day and with or without meals. Administer immediately after the powder is suspended.

Renal Dose Adjustments

Exenatide is not recommended for use in patients with creatinine clearance less than 30 mL/min.

Liver Dose Adjustments

Data not available

Dose Adjustments

The risk of hypoglycemia is increased when exenatide is used in combination with a sulfonylurea. Therefore, patients receiving a sulfonylurea may require a lower dose of the sulfonylurea to reduce the risk of hypoglycemia.

When exenatide is used in combination with insulin, the dose of insulin should be evaluated. In patients at increased risk of hypoglycemia consider reducing the dose of insulin. The concurrent use of exenatide with prandial insulin has not been studied and cannot be recommended.

Precautions

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

Dialysis

Exenatide is not recommended for use in patients with creatinine clearance less than 30 mL/min.

Other Comments

The US FDA requires a Risk Evaluation and Mitigation Strategy (REMS) for exenatide extended-release for injectable suspension. It includes a communication plan. Additional information is available at www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm111350.htm.

Each dose of exenatide immediate release solution should be administered as a SC injection in the thigh, abdomen, or upper arm at any time within the 60 minute period before the morning and evening meals (or before the two main meals of the day, approximately 6 hours or more apart). Exenatide immediate release should not be administered after a meal. If a dose is missed, the treatment regimen should be resumed as prescribed with the next scheduled dose.

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