Etonogestrel Side Effects

Not all side effects for etonogestrel may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to etonogestrel: intradermal implant

Along with its needed effects, etonogestrel may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking etonogestrel:

More common
  • Breast pain
  • chills
  • cough
  • diarrhea
  • fever
  • general feeling of discomfort or illness
  • headache
  • joint pain
  • loss of appetite
  • muscle aches and pain
  • nausea
  • runny nose
  • shivering
  • sore throat
  • sweating
  • trouble sleeping
  • unusual tiredness or weakness
  • vomiting
Less common
  • Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • bloating
  • blurred vision or other changes in vision
  • breast discharge
  • breast enlargement
  • burning while urinating
  • difficult or painful urination
  • difficulty with breathing
  • difficulty with swallowing
  • dizziness
  • fast heartbeat
  • headache, severe and throbbing
  • hives
  • itching
  • lumps in the breasts
  • nervousness
  • noisy breathing
  • painful or tender cysts in the breasts
  • pounding in the ears
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • shortness of breath
  • skin rash
  • slow or fast heartbeat
  • stomach or pelvic discomfort, aching, or heaviness
  • swelling of the hands, ankles, feet, or lower legs
  • tightness in the chest
  • wheezing
Rare
  • Collection of blood under the skin at the injection site
  • deep, dark purple bruise at the injection site

Some side effects of etonogestrel may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Back pain
  • blemishes on the skin, pimples
  • body aches or pain
  • crying
  • depersonalization
  • discouragement
  • dysphoria
  • ear congestion
  • euphoria
  • feeling sad or empty
  • hoarseness
  • increased clear or white vaginal discharge
  • increased weight
  • irregular bleeding cycle
  • irritability
  • itching of the vagina or genital area
  • light vaginal bleeding between regular menstrual periods
  • loss of interest or pleasure
  • loss of voice
  • mental depression
  • nasal congestion
  • pain, cramps, or heavy menstrual bleeding
  • pain during sexual intercourse
  • pain or tenderness around the eyes and cheekbones
  • paranoia
  • quick to react or overreact emotionally
  • rapidly changing moods
  • stomach pain
  • tender, swollen glands in the neck
  • thick, white vaginal discharge with no odor or with a mild odor
  • trouble concentrating
  • voice changes
Less common
  • Abdominal or stomach bloating and cramping
  • abnormal ejaculation
  • abnormal or decreased touch sensation
  • acid or sour stomach
  • belching
  • bone pain
  • burning feeling in the chest or stomach
  • decreased interest in sexual intercourse
  • difficulty having a bowel movement (stool)
  • difficulty with moving
  • dull ache or feeling of pressure or heaviness in the legs
  • earache, redness, or swelling in the ear
  • excess air or gas in the stomach or intestines
  • feeling of vaginal pressure
  • feeling of warmth
  • hair loss or thinning of the hair
  • heartburn
  • inability to have or keep an erection
  • increased appetite
  • increased hair growth on the forehead, back, arms, and legs
  • indigestion
  • itching skin near damaged veins
  • lack or loss of strength
  • loss in sexual ability, desire, drive, or performance
  • muscle cramping or stiffness
  • passing gas
  • pelvic pain
  • redness of the face, neck, arms, and occasionally upper chest
  • sleepiness or unusual drowsiness
  • sleeplessness
  • sneezing
  • stomach upset or pain
  • stuffy nose
  • swollen joints
  • tenderness in the stomach area
  • unable to sleep
  • vaginal burning or pain
  • weight loss

For Healthcare Professionals

Applies to etonogestrel: subcutaneous implant

Local

Local side effects have included insertion site pain.

Dermatologic

Dermatologic side effects have included acne.

General

General side effects have included weight increase, influenza-like symptoms, and pain.

Gastrointestinal

Gastrointestinal side effects have included abdominal pain and nausea.

Genitourinary

Genitourinary side effects have included bleeding irregularities, vaginitis, dysmenorrhea, and leukorrhea.

Nervous system

Nervous system side effects have included headache, dizziness,and nervousness.

Psychiatric

Psychiatric side effects have included emotional liability and depression.

Musculoskeletal

Musculoskeletal side effects have included back pain.

Respiratory

Respiratory side effects have included sinusitis, pharyngitis, and upper respiratory tract infection.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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