Esterified estrogens / methyltestosterone Side Effects

Not all side effects for esterified estrogens / methyltestosterone may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to esterified estrogens / methyltestosterone: oral tablet

In addition to its needed effects, some unwanted effects may be caused by esterified estrogens / methyltestosterone. In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking esterified estrogens / methyltestosterone:

More common
  • Absent, missed, or irregular menstrual periods
  • acne or oily skin
  • decreased breast size
  • enlarging clitoris
  • hoarseness or deepening of the voice
  • menstrual changes
  • stopping of menstrual bleeding
  • unnatural hair growth or loss
Rare
  • Continuing nausea
  • cough
  • dark-colored urine
  • difficulty with swallowing
  • dizziness
  • fast heartbeat
  • fever
  • hives
  • itching
  • light-colored stools
  • loss of appetite
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • purple or red-colored spots on the body or inside the mouth or nose
  • shortness of breath
  • skin rash
  • sore throat
  • tightness in the chest
  • unusual tiredness or weakness
  • vomiting
  • wheezing
Incidence not known
  • Abdominal or stomach bloating, cramps, or pain
  • anxiety
  • bleeding from gums or nose
  • blistering, peeling, or loosening of the skin
  • bloating
  • bloody or cloudy urine
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • change in vaginal discharge
  • changes in skin color, pain, or tenderness
  • chest pain or discomfort
  • chills
  • clay-colored stools
  • clear or bloody discharge from nipple
  • confusion
  • constipation
  • convulsions
  • darkening of urine
  • decrease in amount of urine
  • diarrhea
  • difficult, burning, or painful urination
  • difficulty with breathing
  • difficulty with moving
  • difficulty with speaking
  • dimpling of the breast skin
  • dizziness or lightheadedness
  • double vision
  • eye pain
  • fainting
  • fever
  • fluid-filled skin blisters
  • frequent urge to urinate
  • headache
  • heavy bleeding
  • inability to move the arms, legs, or facial muscles
  • inability to speak
  • indigestion
  • inverted nipple
  • irregular heartbeats
  • itching of the vagina or genital area
  • joint or muscle pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • light-colored stools
  • loss of appetite
  • lump in the breast or under the arm
  • mood or mental changes
  • muscle cramps in the hands, arms, feet, legs, or face
  • muscle pain or stiffness
  • nausea
  • noisy, rattling breathing
  • numbness and tingling around the mouth, fingertips, or feet
  • pain
  • pain during sexual intercourse
  • pain in the ankles or knees
  • pain or discomfort in the arms, jaw, back, or neck
  • pain or feeling of pressure in pelvis
  • painful, red lumps under the skin, mostly on the legs
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • pelvic pain
  • persistent crusting or scaling of the nipple
  • pinpoint red or purple spots on the skin
  • poor insight and judgment problems with memory or speech
  • red, irritated eyes
  • redness or swelling of the breast
  • ringing in the ears
  • sensitivity to the sun
  • shortness of breath
  • skin thinness
  • slow speech
  • sore on the skin of the breast that does not heal
  • sore throat
  • sores, ulcers, or white spots in the mouth or on the lips
  • stomach pain
  • sudden shortness of breath or troubled breathing
  • sweating
  • swelling
  • swelling of the fingers, hands, feet, or lower legs
  • tenderness of the breast
  • thick, white curd-like vaginal discharge without odor or with mild odor
  • tiredness
  • tremor
  • trouble recognizing objects
  • trouble thinking and planning
  • trouble walking
  • troubled breathing at rest
  • unexpected or excess milk flow from breasts
  • unpleasant breath odor
  • vaginal bleeding
  • vision changes
  • vomiting of blood
  • weakness
  • weight gain
  • yellow eyes or skin

Some of the side effects that can occur with esterified estrogens / methyltestosterone may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Incidence not known
  • Blemishes on the skin
  • brown, blotchy spots on the exposed skin
  • decreased interest in sexual intercourse
  • depression
  • headache, severe and throbbing
  • inability to have or keep an erection
  • increase or decrease in weight
  • increased hair growth, especially on the face
  • increased in sexual ability, desire, drive, or performance
  • increased interest in sexual intercourse
  • irritability
  • leg cramps
  • loss in sexual ability, desire, drive, or performance
  • loss of hair
  • mental depression
  • pimples
  • redness of the skin
  • swelling or inflammation of the mouth
  • twitching, uncontrolled movements of the tongue, lips, face, arms, or legs

For Healthcare Professionals

Applies to esterified estrogens / methyltestosterone: oral tablet

Cardiovascular

Cardiovascular side effects have included increased risks of myocardial infarction, pulmonary embolism, deep and superficial venous thrombosis, stroke, and increased blood pressure.[Ref]

Oncologic

Oncologic side effects have included increase risk of breast cancer[Ref]

Genitourinary

Genitourinary side effects have included changes in vaginal bleeding pattern and abnormal withdrawal bleeding or flow, breakthrough bleeding, spotting, dysmenorrhea, increase in size of uterine leiomyomata, vaginitis, including vaginal candidiasis, change in amount of cervical secretion, changes in cervical ectropion, ovarian cancer, endometrial hyperplasia, endometrial cancer, and cystitis-like syndrome. Side effects involving the breasts have included tenderness, enlargement, pain, nipple discharge, galactorrhea, and fibrocystic breast changes. Side effects of androgen therapy are amenorrhea and other menstrual irregularities, and virilization, including deepening of the voice and clitoral enlargement. The latter usually is not reversible after androgens are discontinued.[Ref]

Gastrointestinal

Gastrointestinal side effects have included nausea, vomiting, abdominal cramps, bloating, cholestatic jaundice, increased incidence of gallbladder disease, pancreatitis, and enlargement of hepatic hemangiomas. Additional side effects have included alterations in liver function test, rarely hepatocellular neoplasms, and peliosis hepatis.[Ref]

Dermatologic

Dermatologic side effects have included chloasma or melasma that may persist when drug is discontinued, erythema multiforme, erythema nodosum, hemorrhagic eruption, loss of scalp hair, hirsutism, pruritus, acne, and rash.[Ref]

Ocular

Ocular side effects have included retinal vascular thrombosis, steepening of corneal curvature, and intolerance to contact lenses.[Ref]

Nervous system

Nervous system side effects have included headache, migraine, dizziness, mental depression, chorea, nervousness, mood disturbances, irritability, exacerbation of epilepsy, and dementia. Additional side effects have included increased or decreased libido, headache, anxiety, depression, and generalized paresthesia.[Ref]

Hematologic

Hematologic side effects have included suppression of clotting factors II, V, VII, and X, bleeding in patients on concomitant anticoagulant therapy, polycythemia, and aggravation of porphyria.[Ref]

Hypersensitivity

Hypersensitivity side effects have included urticaria, angioedema, and anaphylactoid/anaphylactic reactions.[Ref]

Respiratory

Respiratory side effects have included exacerbation of asthma.[Ref]

General

General side effects have included increase or decrease in weight, edema, arthralgias, and leg cramps.[Ref]

Metabolic

Metabolic side effects have included reduced carbohydrate tolerance, increased serum cholesterol, retention of sodium, chloride, water, potassium, calcium, and inorganic phosphates.[Ref]

References

1. "Product Information. Estratest H.S. (esterified estrogens-methyltestosterone)." Solvay Pharmaceuticals Inc, Marietta, GA.

2. "Product Information. Estratest (esterified estrogens-methyltestosterone)." Solvay Pharmaceuticals Inc, Marietta, GA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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