Eppy / N Side Effects
Generic Name: epinephrine ophthalmic
Note: This page contains information about the side effects of epinephrine ophthalmic. Some of the dosage forms included on this document may not apply to the brand name Eppy / N.
Not all side effects for Eppy / N may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
For the Consumer
Applies to epinephrine ophthalmic: ophthalmic solution
Get emergency medical help if you have any of these signs of an allergic reaction while taking epinephrine ophthalmic (the active ingredient contained in Eppy / N) hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
severe stinging or burning in your eyes;
fast, pounding, or uneven heart rate;
sweating, shaking, feeling like you might pass out; or
high blood pressure (severe headache, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath).
Less serious side effects of epinephrine ophthalmic may include:
mild burning, stinging, or itching of your eyes;
pain behind your eyebrows.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
For Healthcare Professionals
Applies to epinephrine ophthalmic: ophthalmic solution
Chronic ophthalmic application of epinephrine to aphakic patients may cause maculopathy in up to 28% of patients (macular edema, vascular spasm, hemorrhages), which can result in distorted vision, central scotoma, and/or loss of visual acuity. This maculopathy can reverse within six months upon drug withdrawal.
A single case of madarosis (loss of eyelashes) has been associated with topical epinephrine. After the therapy was discontinued, the lashes grew back.[Ref]
Ocular side effects have included stinging and burning, lacrimation, and local discomfort upon application in up to 62% of patients. Browache, eye pain/ache, conjunctival hyperemia, allergic lid reactions, mydriasis, blurry vision, photophobia have been reported. Ocular cicatrization, pemphigoid, loss of eyelashes, and maculopathy have been reported rarely. Prolonged use can cause corneal edema, refractoriness of superficial blood vessels to constrict, and deposition of brownish oxidation products of epinephrine in the palpebral conjunctiva.[Ref]
Cardiovascular side effects associated with ocularly applied epinephrine have rarely included palpitations, tachycardia, extrasystoles, premature ventricular depolarizations, cardiac arrhythmias, and hypertension.[Ref]
Nervous system side effects associated with ocularly applied epinephrine have included faintness, trembling, pallor, headache, tremors, and perspiration.[Ref]
Hypersensitivity reactions after ocular application may present as diffuse vascular engorgement, follicular hypertrophy, chemosis, conjunctivitis, and/or iritis.[Ref]
In general, systemic side effects after topical application of epinephrine to the eye are more likely if the corneum is damaged or permeability is increased by tonometry, surgery, inflammation, or topical application of a local anesthetic.[Ref]
1. Becker B, Montgomery SW, Kass MA, Shin DH "Increased ocular and systemic responsiveness to epinephrine in primary open-angle glaucoma." Arch Ophthalmol 95 (1977): 789-90
2. Obstbaum SA, Galin MA, Poole TA "Topical epinephrine and cystoid macular edema." Ann Ophthalmol 8 (1976): 455-8
3. Fiore PM "Drug-induced ocular cicatrization." Int Ophthalmol Clin 29 (1989): 147-50
4. Goldstein JH "Effects of drugs on cornea, conjunctiva, and lids." Int Ophthalmol Clin 11 (1971): 13-34
5. Spaeth GL "Nasolacrimal duct obstruction caused by topical epinephrine." Arch Ophthalmol 77 (1967): 355-7
6. Cerasoli JR "Effects of drugs on the retina." Int Ophthalmol Clin 11 (1971): 121-35
7. Mooney D "Pigmentation after long-term topical use of adrenaline compounds." Br J Ophthalmol 54 (1970): 823-6
8. Wandel T, Spinak M "Toxicity of dipivalyl epinephrine." Ophthalmology 88 (1981): 259-60
9. Drance SM, Ross RA "The ocular effects of epinephrine." Surv Ophthalmol 14 (1970): 330-5
10. Thomas JV, Gragoudas ES, Blair NP, Lapus JV "Correlation of epinephrine use and macular edema in aphakic glaucomatous eyes." Arch Ophthalmol 96 (1978): 625-8
11. Mackool RJ, Muldoon T, Fortier A, Nelson D "Epinephrine-induced cystoid macular edema in aphakic eyes." Arch Ophthalmol 95 (1977): 791-3
12. Mahmood MA, Pillai S "Epinephrine staining of a soft contact lens. Case report." Arch Ophthalmol 105 (1987): 1021-2
13. Kass MA, Stamper RL, Becker B "Madarosis in chronic epinephrine therapy." Arch Ophthalmol 88 (1972): 429-31
14. Henkind P, Friedman AH "External ocular pigmentation." Int Ophthalmol Clin 11 (1971): 87-111
15. "Product Information. Epifrin Sterile Ophthalmic Solution (epinephrine)." Allergan Inc, Irvine, CA.
16. Kass MA, Mandell AI, Goldberg I, Paine JM, Becker B "Dipivefrin and epinephrine treatment of elevated intraocular pressure: a comparative study." Arch Ophthalmol 97 (1979): 1865-6
17. Lansche RK "Systemic reactions to topical epinephrine and phenylephrine." Am J Ophthalmol 61 (1966): 95-8
18. Korey MS, Hodapp E, Kass MA, Goldberg I, Gordon M, Becker B "Timolol and epinephrine: long-term evaluation of concurrent administration." Arch Ophthalmol 100 (1982): 742-5
19. Ellis PP "Systemic reactions to topical therapy." Int Ophthalmol Clin 11 (1971): 1-11
20. Leon AS, Abrams WB "The role of catecholamines in producing arrhythmias." Am J Med Sci 262 (1971): 9-13
21. Kolker AE, Becker B "Epinephrine maculopathy." Arch Ophthalmol 79 (1968): 552-62
22. Meyers EF, Ramirez RC, Boniuk I "Grand mal seizures after retrobulbar block." Arch Ophthalmol 96 (1978): 847
23. Gaspari AA "Contact allergy to ophthalmic dipivalyl epinephrine hydrochloride: demonstration by patch testing." Contact Dermatitis 28 (1993): 35-7
24. Alani SD, Alani MD "Allergic contact dermatits and conjunctivitis from epinephrine." Contact Dermatitis 2 (1976): 147-50
25. Sonntag JR, Brindley GO, Shields MB, Arafat NI, Phelps CD "Timolol and epinephrine. Comparisin of efficacy and side effects." Arch Ophthalmol 97 (1979): 273-7
26. Fiore PM, Cinotti AA "Systemic effects of intraocular epinephrine during cataract surgery." Ann Ophthalmol 20 (1988): 23-5
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