Epinephrine Ophthalmic Dosage

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Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Glaucoma (Open Angle)

Initial dose: 1 drop in the affected eye(s) 1 to 2 times daily.
Maintenance dose: Individualize based on response.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Because epinephrine is primarily metabolized by the liver, it is recommended that multiple doses or dose increments be given cautiously due to this patient's liver disease.

Precautions

Solution may contain sodium metabisulfite, which may cause life-threatening allergic reactions in sulfite-sensitive patients.

Contraindicated in patients with a narrow angle who do not have glaucoma or in patients in whom the nature of glaucoma has not been clearly established.

Epinephrine ophthalmic solution contains benzalkonium chloride which may be absorbed by contact lenses. Contact lenses should be removed prior to administration of the eye drop and may be reinserted 15 minutes later.

Patients should be instructed to avoid allowing the tip of the container to contact the eye, eyelid, fingers or any other surface.

Dialysis

The plasma clearance of epinephrine is not enhanced by hemodialysis. Two small studies have shown no significant difference between pre- and postdialysis plasma concentrations. There are no data on the peritoneal dialysis clearance of epinephrine.

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