Epinephrine use while Breastfeeding
Drugs containing Epinephrine: EpiPen, Adrenalin, Auvi-Q, EpiPen 2-Pak, Septocaine, EpiPen Jr, Adrenaclick, Adrenalin Chloride, EpiPen Auto-Injector, Primatene Mist, Show all 54 »EpiPen JR Auto-Injector, Bronkaid Mist, Asthmahaler, Sus-Phrine Injection, EpiPen JR 2-Pak, Glaucon, Articadent, Bronchial Mist with Pump, Epifrin, Twinject Auto-Injector, Twinject Auto-Injector Two Pack, P2E1, E-Pilo-2, Zorcaine, Twinject, Epinal, Vivacaine, Citanest Forte, Lets Kit, LidoSite, Xylocaine with Epinephrine, E-Pilo-1, P3E1, P4E1, Xylocaine with Epinephrine Dental Cartridges, E-Pilo-6, P6E1, E-Pilo-4, P1E1, Medihaler-Epi, Orabloc, Ana-Guard, Sensorcaine-MPF with Epinephrine, Marcaine HCl with Epinephrine, Ana-Kit, Sensorcaine with Epinephrine, Bronitin, Epi EZ Pen, Duranest-MPF-Epinephrine, Xylocaine HCl with Epinephrine, Raphon, Adrenalin Topical, Eppy/N, Xylocaine-MPF-Epinephrine
Epinephrine Levels and Effects while Breastfeeding
Summary of Use during Lactation
No information is available on the use of epinephrine during breastfeeding. Because of its poor oral bioavailability and short half-life, any epinephrine in milk is unlikely to affect the infant. High intravenous doses of epinephrine might reduce milk production or milk letdown. Low-dose epidural, topical, inhaled or ophthalmic epinephrine are unlikely to interfere with breastfeeding. To substantially diminish the effect of the drug after using eye drops, place pressure over the tear duct by the corner of the eye for 1 minute or more, then remove the excess solution with an absorbent tissue.
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information in nursing mothers was not found as of the revision date. Intravenous epinephrine infusion in nonnursing subjects and in women with hyperprolactinemia decreases serum prolactin concentrations. Animal data indicate that intraarterial epinephrine can decrease serum oxytocin and reduce milk production at lower doses by possible peripheral vasoconstriction, which reduces the amount of oxytocin reaching the mammary gland. However, low-dose infusion of epinephrine as part of epidural analgesia does not impair breastfeeding in nursing mothers. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.
Nicoletti I, Filipponi P, Sfrappini M et al. Catecholamines and pituitary function. I. Effects of catecholamine synthesis inhibition and subsequent catecholamine infusion on gonadotropin and prolactin serum levels in normal cycling women and in women with hyperprolactinemic amenorrhea. Horm Res. 1984;19:158-70. PMID: 6425187
Gorewit RC, Aromando MC. Mechanisms involved in the adrenalin-induced blockade of milk ejection in dairy cattle. Proc Soc Exp Biol Med. 1985;180:340-7. PMID: 4048172
Radzyminski S. The effect of ultra low dose epidural analgesia on newborn breastfeeding behaviors. J Obstet Gynecol Neonatal Nurs. 2003;32:322-31. PMID: 12774874
Chang ZM, Heaman MI. Epidural analgesia during labor and delivery: effects on the initiation and continuation of effective breastfeeding. J Hum Lact. 2005;21:305-14. PMID: 16113019
CAS Registry Number
LactMed Record Number
Last Revision Date
Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.