Epiduo Side Effects

Generic name: adapalene / benzoyl peroxide topical

Note: This document contains side effect information about adapalene / benzoyl peroxide topical. Some of the dosage forms listed on this page may not apply to the brand name Epiduo.

Some side effects of Epiduo may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to adapalene / benzoyl peroxide topical: topical gel

Get emergency medical help if you have any of these signs of an allergic reaction while taking adapalene / benzoyl peroxide topical: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

During your first 4 weeks of using adapalene and benzoyl peroxide topical, your skin may be dry, red, or scaly. You may also feel some burning or stinging. Call your doctor if these side effects are severe.

Less serious side effects may include mild itching.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to adapalene / benzoyl peroxide topical: topical gel

Dermatologic

Dermatologic reactions during a clinical study included erythema, scaling, dryness and stinging/burning. These reactions occurred in 27% to 41% of study participants and were mostly mild to moderate, with only 1% to 3% experiencing severe reactions. Analysis of study data during a 12-week period showed that side effects such as erythema, scaling, dryness, and stinging/burning peaked during the first week of therapy and decreased thereafter.

Dermatologic side effects have included dry skin (7%), contact dermatitis (3%), application site burning (2%), application site irritation (1%), and skin irritation (1%).

General

General side effects reported postmarketing have included eyelid edema, sunburn, blister, pain of skin, pruritus, swelling face, conjunctivitis, skin discoloration, rash, eczema, and allergic contact dermatitis.

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