DuoDote Side Effects

Generic name: atropine / pralidoxime

Note: This document contains side effect information about atropine / pralidoxime. Some of the dosage forms listed on this page may not apply to the brand name DuoDote.

Some side effects of DuoDote may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to atropine / pralidoxime: intramuscular solution

Some of the side effects of atropine and pralidoxime may be similar to the symptoms of poisoning. Your caregivers will watch you closely to determine whether your body is responding well to the medication, or if you are having any serious side effects.

Get emergency medical help if you have any of these signs of an allergic reaction while taking atropine / pralidoxime: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if you have a serious side effect such as:

• pounding heartbeats or fluttering in your chest;

• painful or difficult urination;

• trouble swallowing;

• feeling like you might pass out;

• confusion;

• loss of movement in any part of your body;

• slow heart rate, weak pulse, fainting, slow breathing (breathing may stop); or

• chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling.

Less serious side effects of atropine / pralidoxime may include:

• dry mouth, dry nose, dry skin;

• dry eyes, blurred vision;

• increased sensitivity of your eyes to light;

• headache;

• dizziness, drowsiness;

• muscle weakness;

• constipation, stomach pain, bloating, nausea, vomiting;

• loss of interest in sex, impotence; or

• mild skin rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to atropine / pralidoxime: intramuscular solution

Nervous system

Nervous system side effects have included confusion, headache, dizziness, restlessness, tremor, fatigue, locomotor difficulties, delirium followed by hallucinations, depression, and, ultimately medullary paralysis and death.

Cardiovascular

Cardiovascular side effects have included flushing, sinus tachycardia, palpitations, premature ventricular contractions, atrial flutter, atrial fibrillation, ventricular flutter, ventricular fibrillation, cardiac syncope, asystole, and myocardial infarction.

Gastrointestinal

Gastrointestinal side effects have included dysphagia, paralytic ileus, dryness of the mouth, constipation, abdominal pain, abdominal distention, nausea and vomiting.

Ocular

Ocular side effects have included blurred vision, dry eyes, photophobia, and acute angle closure glaucoma.

Hypersensitivity

Hypersensitivity side effects have included skin rashes which have progressed to exfoliation. Anaphylactic reaction and laryngospasm are rare.

Musculoskeletal

Musculoskeletal side effects have included muscular weakness.

Dermatologic

Dermatologic side effects have included maculopapular rash, petechial rash, and scarlatiniform rash. Anhidrosis may produce heat intolerance and impairment of temperature regulation in a hot environment.

Genitourinary

Genitourinary side effects have included urinary hesitancy or retention, loss of libido, and impotence.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This information does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of information provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.