DuoDote Dosage

Generic name: atropine and pralidoxime chloride
Dosage form: injection

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

THE DUODOTE AUTO-INJECTOR SHOULD BE ADMINISTERED BY EMERGENCY MEDICAL SERVICES PERSONNEL WHO HAVE HAD ADEQUATE TRAINING IN THE RECOGNITION AND TREATMENT OF NERVE AGENT OR INSECTICIDE INTOXICATION.

CAUTION! INDIVIDUALS SHOULD NOT RELY SOLELY UPON ATROPINE AND PRALIDOXIME TO PROVIDE COMPLETE PROTECTION FROM CHEMICAL NERVE AGENTS AND INSECTICIDE POISONING.

PRIMARY PROTECTION AGAINST EXPOSURE TO CHEMICAL NERVE AGENTS AND INSECTICIDE POISONING IS THE WEARING OF PROTECTIVE GARMENTS INCLUDING MASKS DESIGNED SPECIFICALLY FOR THIS USE.

EVACUATION AND DECONTAMINATION PROCEDURES SHOULD BE UNDERTAKEN AS SOON AS POSSIBLE. MEDICAL PERSONNEL ASSISTING EVACUATED VICTIMS OF NERVE AGENT POISONING SHOULD AVOID CONTAMINATING THEMSELVES BY EXPOSURE TO THE VICTIM'S CLOTHING.

DuoDote is indicated for the treatment of poisoning by organophosphorous nerve agents as well as organophosphorous insecticides. DuoDote should only be administered to patients experiencing symptoms of organophosphorous poisoning in a situation where exposure is known or suspected. DuoDote should be administered as soon as symptoms of organophosphorous poisoning appear.

The DuoDote Auto-Injector is intended as an initial treatment of the symptoms of organophosphorous insecticide or nerve agent poisonings; definitive medical care should be sought immediately.

NERVE AGENT AND INSECTICIDE POISONING SYMPTOMS

Common symptoms of organophosphorous exposure are listed below. Individuals may not have all symptoms:

MILD SYMPTOMS SEVERE SYMPTOMS
 
- Blurred vision, miosis
 
- Strange or confused behavior
 
- Excessive, unexplained teary eyes
 
- Severe difficulty breathing or copious secretions from lungs/airway
 
- Excessive, unexplained runny nose
 
- Severe muscular twitching and general weakness
 
- Increased salivation such as sudden drooling
 
- Involuntary urination and defecation
 
- Chest tightness or difficulty breathing
 
- Convulsions
 
- Tremors throughout the body or muscular twitching
 
- Unconsciousness
 
- Nausea and/or vomiting
 
- Unexplained wheezing, coughing or increased airway secretions
 
- Acute onset of stomach cramps
 
- Tachycardia or bradycardia

Three (3) DuoDote Auto-Injectors should be available for use in each patient (including emergency medical services personnel) at risk for organophosphorous poisoning; one (1) for mild symptoms plus two (2) more for severe symptoms as described below. Each DuoDote Auto-Injector delivers atropine 2.1 mg plus pralidoxime chloride 600 mg.

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