Skip to Content

Deferiprone Side Effects

Not all side effects for deferiprone may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to deferiprone: oral tablet

In addition to its needed effects, some unwanted effects may be caused by deferiprone. In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking deferiprone:

More common
  • Black, tarry stools
  • chills
  • cough
  • fever
  • lower back or side pain
  • painful or difficult urination
  • pale skin
  • shortness of breath
  • sore throat
  • ulcers, sores, or white spots in the mouth
  • unusual bleeding or bruising
  • unusual tiredness or weakness
Less common
  • Fever with or without chills
  • general feeling of tiredness or weakness
  • hoarseness
Incidence not known
  • Abdominal or stomach pain
  • anxiety
  • bleeding gums
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • blood in the urine or stools
  • blurred vision
  • chest pain or discomfort
  • clay-colored stools
  • confusion
  • convulsions
  • dark urine
  • decreased urination
  • dilated neck veins
  • dizziness or lightheadedness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • drowsiness
  • dry mouth
  • extreme fatigue
  • fainting
  • fast or irregular heartbeat
  • headache
  • hives
  • increase in heart rate
  • increased sweating
  • irregular breathing
  • irritation
  • itching
  • joint pain, stiffness, or swelling
  • large, flat, blue or purplish patches in the skin
  • loss of appetite
  • muscle tremors
  • nausea
  • nervousness
  • painful knees and ankles
  • pinpoint red spots on the skin
  • pounding in the ears
  • raised red swellings on the skin, the buttocks, legs, or ankles
  • rapid weight gain
  • rapid, deep breathing
  • rapid, shallow breathing
  • rash
  • redness of the skin
  • restlessness
  • severe nausea or vomiting
  • slow heartbeat
  • sneezing
  • spots on your skin resembling a blister or pimple
  • stomach cramps
  • sudden shortness of breath or troubled breathing
  • sugar in the urine
  • sunken eyes
  • sweating
  • swelling around the eyes
  • swelling of the eyelids, face, lips, hands, or feet
  • thirst
  • tightness in the chest
  • tingling of the hands or feet
  • trouble with balance
  • troubled breathing or swallowing
  • unpleasant breath odor
  • unusual weight gain or loss
  • vision changes
  • vomiting of blood
  • weight gain
  • wrinkled skin
  • yellow eyes or skin

Some of the side effects that can occur with deferiprone may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Abdominal or stomach discomfort
  • difficulty with moving
  • muscle pain or stiffness
  • reddish or brow discoloration of the urine
Less common
  • Acid or sour stomach
  • back pain
  • belching
  • diarrhea
  • heartburn
  • increased or decreased appetite
  • indigestion
  • pain in the arms or legs
  • stomach upset
Incidence not known
  • Bloody nose
  • clenching, gnashing, or grinding teeth
  • constipation
  • coughing or spitting up blood
  • depression
  • difficulty opening the mouth
  • difficulty with speaking
  • drooling
  • hives or welts
  • impaired psychomotor skills
  • increased sensitivity of the skin to sunlight
  • lockjaw
  • loss of appetite
  • loss of balance control
  • muscle spasm, especially of the neck and back
  • muscle trembling, jerking, or stiffness
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • redness or other discoloration of the skin
  • restlessness
  • severe sunburn
  • shuffling walk
  • sleepiness or unusual drowsiness
  • stiffness of the limbs
  • stomach bloating, burning, cramping, or pain
  • twisting movements of the body
  • uncontrolled movements, especially of the face, neck, and back

For Healthcare Professionals

Applies to deferiprone: oral tablet

General

The most common adverse events were chromaturia, nausea, vomiting, abdominal pain, alanine aminotransferase increased, arthralgia, and neutropenia.[Ref]

Gastrointestinal

Gastrointestinal effects are more frequent at the beginning of therapy, and in most patients resolve within a few weeks without the discontinuation of treatment.[Ref]

Very common (10% or more): Nausea (12.6%), abdominal pain/discomfort (10.4%), vomiting
Common (1% to 10%): Diarrhea, dyspepsia, abdominal discomfort, abdominal pain, abdominal pain upper
Uncommon (0.1% to 1%): Abdominal distension, abdominal pain lower, aphthous stomatitis, constipation, epigastric discomfort, eructation, gastritis, reflux esophagitis, stomach discomfort, gastroenteritis, gastroenteritis viral
Postmarketing reports: Enterocolitis, rectal hemorrhage, gastric ulcer, pancreatitis, parotid gland enlargement, cecitis, dysphagia[Ref]

Genitourinary

Very common (10% or more): Chromaturia (14.6%)
Uncommon (0.1% to 1%): Pollakiuria, amenorrhea, menstruation irregular
Postmarketing reports: Glycosuria, hypospadias, congenital anomaly, non-acute porphyria, urinary tract infection, urine color abnormal, intra-uterine death, balanitis[Ref]

Musculoskeletal

Very common (10% or more): Arthralgia
Common (1% to 10%): Back pain, pain in extremity, arthropathy, joint swelling
Uncommon (0.1% to 1%): Epicondylitis, arthritis, bone pain, joint crepitation, joint effusion, joint range of motion decreased, joint stiffness, metatarsalgia, muscle spasms, muscular weakness, musculoskeletal chest pain, musculoskeletal pain, myalgia, polyarthritis, synovial cyst
Postmarketing reports: Myositis, chondropathy, trismus[Ref]

Hematologic

Common (1% to 10%): Neutrophil count decreased, neutropenia, agranulocytosis, white blood cell count decreased
Uncommon (0.1% to 1%): Blood disorder, hypersplenism, leukopenia, thrombocytopenia, platelet count decreased, platelet count increased
Postmarketing reports: Thrombocytosis, pancytopenia, febrile neutropenia, thrombocythemia, granulocytopenia, hemoglobin decrease, neutropenic sepsis[Ref]

Hepatic

Common (1% to 10%): Alanine aminotransferase increased, aspartate aminotransferase increased, increased liver enzymes
Uncommon (0.1% to 1%): Hepatic pain, hepatitis, hepatomegaly, jaundice, liver tenderness, cytomegalovirus hepatitis, blood bilirubin increased, hepatic enzyme increased
Postmarketing reports: Hepatic function abnormal, infectious hepatitis[Ref]

Other

Common (1% to 10%): Fatigue, peripheral edema
Uncommon (0.1% to 1%): Deafness, ear pain, tinnitus, vertigo, asthenia, chest pain, discomfort, fatigue, influenza like illness, malaise, pyrexia, thirst, diabetic foot infection, sepsis, Yersinia infection, transfusion reaction, blood creatinine increased, blood phosphorus increased, blood zinc decreased, gamma-glutamyl transferase increased
Frequency not reported: Progression of fibrosis
Postmarketing reports: Chills, multi-organ failure, pharyngitis, pneumonia, sepsis, blood creatinine phosphokinase increased, difficulty in walking, hyperpyrexia, anti-HBs antibody positive, blood arsenic increased[Ref]

Metabolic

Common (1% to 10%): Increased appetite, weight increased, decreased appetite, anorexia
Uncommon (0.1% to 1%): Weight decreased, fluid retention
Postmarketing reports: Metabolic acidosis, dehydration, metabolic disorder[Ref]

Respiratory

Uncommon (0.1% to 1%): Influenza, nasopharyngitis, upper respiratory tract infection, asthma, dry throat, oropharyngeal pain
Postmarketing reports: Acute respiratory distress syndrome, epistaxis, hemoptysis, pulmonary embolism, respiratory acidosis, dyspnea, lung disorder, oropharyngolaryngeal pain, pharyngeal erythema, tonsillitis, parapharyngeal abscess[Ref]

Nervous system

Common (1% to 10%): Headache
Uncommon (0.1% to 1%): Dizziness, hypogeusia, migraine, somnolence
Frequency not reported: Psychomotor slowdown, hand movements, axial hypotonia
Postmarketing reports: Cerebellar syndrome, cerebral hemorrhage, convulsion, gait disturbance, intracranial pressure increased, psychomotor skills impaired, pyramidal tract syndrome, dystonia, febrile convulsion, coordination abnormal, hypotonia, nystagmus, depressed level of consciousness, balance disorder, enteroviral encephalitis[Ref]

Hypersensitivity

Uncommon (0.1% to 1%): Hypersensitivity
Postmarketing reports: Anaphylactic shock[Ref]

Cardiovascular

Uncommon (0.1% to 1%): Arrhythmia, Torsades de Pointes, electrocardiogram T wave inversion
Postmarketing reports: Atrial fibrillation, cardiac failure, hypotension, hypertension, cardiac disorder, congestive cardiac failure, sinus tachycardia[Ref]

Dermatologic

Uncommon (0.1% to 1%): Alopecia, hyperhidrosis, pruritus, rash, rash generalized, rash pruritic, skin hypopigmentation, urticaria, xeroderma
Frequency not reported: Henoch-Schönlein purpura, urticaria, periorbital edema with skin rash
Postmarketing reports: Cryptococcal cutaneous infection, rash pustular, subcutaneous abscess, hyperhidrosis, photosensitivity reaction, rash erythematous, rash maculopapular, face edema, furuncle, subcutaneous abscess[Ref]

Renal

Postmarketing reports: Hemoglobinuria, renal failure, glycosuria, chromaturia[Ref]

Endocrine

Postmarketing reports: Blood corticotrophin decreased, blood cortisol decreased[Ref]

Ocular

Frequency not reported: Lateral nystagmus
Postmarketing reports: Diplopia, papilledema, retinal toxicity, eye movement disorder, periorbital edema, retinal toxicity, visual impairment[Ref]

Oncologic

Postmarketing reports: Hepatic neoplasm malignant[Ref]

Psychiatric

Postmarketing reports: Bruxism, depression, obsessive-compulsive disorder[Ref]

References

1. Cerner Multum, Inc. "Australian Product Information." O 0

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. "Product Information. Ferriprox (deferiprone)." ApoPharma USA Inc, Rockville, MD.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

Hide