Carbidopa Side Effects

Some side effects of carbidopa may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to carbidopa: oral tablet

Carbidopa alone is not associated with side effects. The following side effects are generally associated with carbidopa and levodopa therapy.

If you experience any of the following serious side effects, stop taking carbidopa and levodopa and seek emergency medical attention or contact your doctor immediately:

  • an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);

  • uncontrolled movements of a part of the body;

  • seizures;

  • persistent nausea, vomiting, or diarrhea;

  • an irregular heartbeat or fluttering in your chest;

  • unusual changes in mood or behavior; or

  • depression or suicidal thoughts.

Other, less serious side effects may be more likely to occur. Continue to take carbidopa and levodopa and talk to your doctor if you experience

  • mild nausea, vomiting, or decreased appetite;

  • constipation, dry mouth, or blurred vision;

  • hand tremor;

  • muscle twitches;

  • dizziness or drowsiness;

  • insomnia, confusion, or nightmares;

  • agitation or anxiety;

  • darkening of urine or sweat; or

  • fatigue.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to carbidopa: compounding powder, oral tablet

General

In general, side effects have not been observed when carbidopa is administered alone. All side effects listed have been reported during concomitant use with levodopa or with carbidopa-levodopa therapy.

Cardiovascular

Cardiovascular side effects including cardiac irregularities, hypertension, myocardial infarction, hypotension (including orthostatic hypotension), palpitation, phlebitis, and syncope have been observed while taking carbidopa with other drugs such as levodopa, and with carbidopa-levodopa in combination product.

Gastrointestinal

Gastrointestinal side effects including abdominal pain, anorexia, bruxism, burning sensation of the tongue, constipation, dark saliva, development of duodenal ulcer, diarrhea, dry mouth, dyspepsia, dysphagia, flatulence, gastrointestinal bleeding, gastrointestinal pain, heartburn, hiccups, sialorrhea, taste alterations, and vomiting have been observed while taking carbidopa along with other drugs such as levodopa, and with carbidopa-levodopa combination product.

Hematologic

Hematologic side effects including hemolytic and nonhemolytic anemia, leukopenia, thrombocytopenia, and agranulocytosis have been observed while using carbidopa with other drugs such as levodopa, and with carbidopa-levodopa combination product.

Hypersensitivity

Hypersensitivity side effects such as angioedema, urticaria, pruritus, Henoch-Schonlein purpura, and bullous lesions, including pemphigus-like reactions, have been reported while carbidopa has been used with other drugs such as levodopa, and with carbidopa-levodopa combination product.

Metabolic

Metabolic side effects including edema, weight gain, and weight loss have been reported while carbidopa has been used with other drugs such as levodopa, and with carbidopa-levodopa combination product.

Musculoskeletal

Musculoskeletal side effects including back pain, leg pain, muscle cramps, shoulder pain, and dyskinesias such as choreiform, dystonic, and other involuntary movements have been reported when carbidopa has been used with other drugs such as levodopa, and with carbidopa-levodopa combination product.

Nervous system

Nervous system side effects including bradykinetic episodes ("on-off" phenomenon), confusion, decreased mental acuity, disorientation, euphoria, dizziness, dream abnormalities including nightmares, insomnia, malaise, faintness, extrapyramidal disorder, falling, ataxia, gait abnormalities, headache, increased tremor, memory impairment, muscle twitching, nervousness, numbness, paresthesia, peripheral neuropathy, somnolence, trismus, activation of latent Horner's syndrome, and increased libido have been reported when carbidopa has been used with other drugs such as levodopa, and with carbidopa-levodopa combination product.

Ocular

Ocular side effects including oculogyric crises, diplopia, blurred vision, dilated pupils, and blepharospasm have been reported when carbidopa has been used with other drugs such as levodopa, and with carbidopa-levodopa combination product. Blepharospasm could be an indication of excess dosage and dosage reduction should be considered.

Psychiatric

Psychiatric side effects including agitation, anxiety, psychotic episodes (including delusions, hallucinations, and paranoid ideation), depression with or without development of suicidal tendencies, and dementia have been reported when carbidopa has been used with other drugs such as levodopa, and with carbidopa-levodopa combination product.

Respiratory

Respiratory side effects including upper respiratory infection, dyspnea, pharyngeal pain, cough, and abnormal breathing patterns have been reported when carbidopa has been used with other drugs such as levodopa, and with carbidopa-levodopa combination product.

Genitourinary

Genitourinary side effects including priapism, dark urine, urinary frequency, urinary incontinence, urinary retention, and urinary tract infection have been reported while taking carbidopa with other drugs such as with levodopa, and with carbidopa-levodopa combination product.

Dermatologic

Dermatologic side effects including increased sweating, dark sweat, flushing, rash, alopecia, and malignant melanoma have been reported while taking carbidopa in combination with other drugs such as levodopa, and with carbidopa-levodopa combination product.

Other

Other side effects including hoarseness, hot flashes, neuroleptic malignant syndrome, and sense of stimulation have been reported when carbidopa has been used with other drugs such as levodopa, and with carbidopa-levodopa combination product.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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