Carbidopa Side Effects
Not all side effects for carbidopa may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
For the Consumer
Applies to carbidopa: oral tablet
Carbidopa alone is not associated with side effects. The following side effects are generally associated with carbidopa and levodopa therapy.
If you experience any of the following serious side effects, stop taking carbidopa and levodopa and seek emergency medical attention or contact your doctor immediately:
an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
uncontrolled movements of a part of the body;
persistent nausea, vomiting, or diarrhea;
an irregular heartbeat or fluttering in your chest;
unusual changes in mood or behavior; or
depression or suicidal thoughts.
Other, less serious side effects may be more likely to occur. Continue to take carbidopa and levodopa and talk to your doctor if you experience
mild nausea, vomiting, or decreased appetite;
constipation, dry mouth, or blurred vision;
dizziness or drowsiness;
insomnia, confusion, or nightmares;
agitation or anxiety;
darkening of urine or sweat; or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
For Healthcare Professionals
Applies to carbidopa: compounding powder, oral tablet
In general, side effects have not been observed when carbidopa is administered alone. All side effects listed have been reported during concomitant use with levodopa or with carbidopa-levodopa therapy. The most common side effects included dyskinesias and nausea.[Ref]
Symptoms related to neuroleptic malignant syndrome are characterized by fever or hyperthermia. Other findings include neurological symptoms such as muscle rigidity, involuntary movements, altered consciousness, mental status changes, other disturbances such as autonomic dysfunction, tachycardia, tachypnea, sweating, hyper- or hypotension, and laboratory findings such as elevated creatine phosphokinase, leukocytosis, myoglobinuria, and increased serum myoglobin.
A causal relationship with concomitant carbidopa and levodopa and the reported side effect of convulsions has not been established.[Ref]
Frequency not reported: Bradykinetic episodes ("on-off" phenomenon), convulsions, dizziness, dyskinesias such as choreiform, dystonic and other involuntary movements, headache, neuroleptic malignant syndrome, oculogyric crises, paresthesia, peripheral neuropathy, somnolence, syncope, taste alterations[Ref]
Frequency not reported: Agitation, bruxism, confusion, dementia, depression with or without development of suicidal tendencies, dream abnormalities (including nightmares), impulse control symptoms, increased libido (including hypersexuality), insomnia, pathological gambling, psychotic episodes (including delusions, hallucinations and paranoid ideation)[Ref]
Psychiatric side effects were reported with concomitant administration of levodopa or carbidopa-levodopa.[Ref]
Frequency not reported: Cardiac irregularities, chest pain, hot flashes, hypertension, hypotension (including orthostatic hypotension), myocardial infarction, palpitation, phlebitis[Ref]
Frequency not reported: Abdominal pain and distress, burning sensation of the tongue, constipation, dark saliva, development of duodenal ulcer, diarrhea, dry mouth, dyspepsia, dysphagia, flatulence, gastrointestinal bleeding, gastrointestinal pain, heartburn, hiccups, nausea, sialorrhea, vomiting[Ref]
Frequency not reported: Abnormal Coombs test, agranulocytosis, decreased hemoglobin and hematocrit, decreased white blood cell count, hemolytic and nonhemolytic anemia, leukopenia, thrombocytopenia[Ref]
Frequency not reported: Abnormal lactic dehydrogenase, anorexia, edema, elevated serum glucose, elevated serum potassium, weight gain, weight loss[Ref]
Frequency not reported: Back pain, leg pain, muscle cramps, shoulder pain[Ref]
Frequency not reported: Bizarre breathing patterns, cough, dyspnea, pharyngeal pain, upper respiratory infection[Ref]
Frequency not reported: Alopecia, angioedema, bullous lesions (including pemphigus-like reactions), dark sweat, flushing, Henoch-Schonlein purpura, increased sweating, malignant melanoma, pruritus, rash, urticaria[Ref]
Frequency not reported: Blurred vision, dilated pupils, diplopia[Ref]
Frequency not reported: Dark urine, priapism, urinary frequency, urinary incontinence, urinary retention, urinary tract infection[Ref]
Frequency not reported: Asthenia, faintness, fatigue, hoarseness, malaise, sense of stimulation[Ref]
Frequency not reported: Abnormalities in alkaline phosphatase, SGOT (AST), SGPT (ALT), and bilirubin.[Ref]
Frequency not reported: Abnormal blood urea nitrogen (BUN), increased serum creatinine and uric acid, protein and glucose in the urine, white blood cells, bacteria and blood in the urine,[Ref]
1. "Product Information. Lodosyn (carbidopa)" DuPont Pharma, Wilmington, DE.
More about carbidopa
- Other brands: Lodosyn
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