Carbidopa Side Effects

Brand Names: Lodosyn

Please note - some side effects for Carbidopa may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects of Carbidopa - for the Consumer

Carbidopa

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Carbidopa:

Confusion; constipation; diarrhea; dizziness; drowsiness; dry mouth; headache; loss of appetite; nausea; taste changes; trouble sleeping; upset stomach; urinary tract infection; vomiting.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; blood in vomit; chest pain; confusion; depression; fast or irregular heartbeat; fever; hallucinations; increased sweating; mental or mood changes; muscle pain or unusual stiffness; severe abdominal pain; severe lightheadedness or fainting; sore throat; thoughts of suicide; unusual bruising or bleeding; unusual or painful movements or spasms of the face, eyelids, mouth, tongue, arms, hands, or legs; vision changes (blurred/double vision); yellowing of the skin or eyes.

Carbidopa/Entacapone/Levodopa

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Carbidopa/Entacapone/Levodopa:

Change in taste; constipation; diarrhea; dizziness; drowsiness; dry mouth; headache; loss of appetite; nausea; upset stomach.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; confusion; dark urine; depression with thoughts of suicide; fainting; fever; hallucinations; increased or irregular heart beat; lack of response to environment; mental or mood changes; muscle pain, stiffness, or rigidity; paranoia; seizures; severe or persistent diarrhea; severe or persistent dizziness; stomach pain; trouble sleeping; unusual or painful movements of the face, eyelids, mouth, tongue, arms, hands, or legs; unusual skin growths or change in the appearance of a mole; unusual sweating; vomiting; yellowing of the skin or eyes.

Carbidopa/Levodopa

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Carbidopa/Levodopa:

Confusion; constipation; diarrhea; dizziness; drowsiness; dry mouth; headache; increased sweating; loss of appetite; nausea; taste changes; trouble sleeping; upset stomach; urinary tract infection; vomiting.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; blood in vomit; chest pain; confusion; depression; fast or irregular heartbeat; fever; hallucinations; mental or mood changes; muscle pain or unusual stiffness; severe abdominal pain; severe lightheadedness or fainting; sore throat; thoughts of suicide; unexplained fever or sweating; unusual bruising or bleeding; unusual or painful movements or spasms of the face, eyelids, mouth, tongue, arms, hands, or legs; vision changes (blurred/double vision); yellowing of the skin or eyes.

Carbidopa/Levodopa/Entacapone

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Carbidopa/Levodopa/Entacapone:

Change in taste; constipation; diarrhea; dizziness; drowsiness; dry mouth; headache; loss of appetite; nausea; upset stomach.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; confusion; dark urine; depression with thoughts of suicide; fainting; fever; hallucinations; increased or irregular heart beat; lack of response to environment; mental or mood changes; muscle pain, stiffness, or rigidity; paranoia; seizures; severe or persistent diarrhea; severe or persistent dizziness; stomach pain; trouble sleeping; unusual or painful movements of the face, eyelids, mouth, tongue, arms, hands, or legs; unusual skin growths or change in the appearance of a mole; unusual sweating; vomiting; yellowing of the skin or eyes.

Carbidopa/Levodopa Orally Disintegrating Tablets

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Carbidopa/Levodopa Orally Disintegrating Tablets:

Confusion; constipation; diarrhea; dizziness; drowsiness; dry mouth; headache; increased sweating; loss of appetite; nausea; taste changes; trouble sleeping; upset stomach; urinary tract infection; vomiting.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; blood in vomit; chest pain; confusion; depression; fast or irregular heartbeat; fever; hallucinations; mental or mood changes; muscle pain or unusual stiffness; severe abdominal pain; severe lightheadedness or fainting; sore throat; thoughts of suicide; unexplained fever or sweating; unusual bruising or bleeding; unusual or painful movements or spasms of the face, eyelids, mouth, tongue, arms, hands, or legs; vision changes (blurred/double vision); yellowing of the skin or eyes.

Carbidopa/Levodopa Sustained-Release Tablets

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Carbidopa/Levodopa Sustained-Release Tablets:

Confusion; constipation; diarrhea; dizziness; drowsiness; dry mouth; headache; increased sweating; loss of appetite; nausea; taste changes; trouble sleeping; upset stomach; urinary tract infection; vomiting.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; blood in vomit; chest pain; confusion; depression; fast or irregular heartbeat; fever; hallucinations; mental or mood changes; muscle pain or unusual stiffness; severe abdominal pain; severe lightheadedness or fainting; sore throat; thoughts of suicide; unexplained fever or sweating; unusual bruising or bleeding; unusual or painful movements or spasms of the face, eyelids, mouth, tongue, arms, hands, or legs; vision changes (blurred/double vision); yellowing of the skin or eyes.

Side Effects by Body System

General

In general, side effects have not been observed when carbidopa is administered alone. All side effects listed have been reported during concomitant use with levodopa or with carbidopa-levodopa therapy.

Cardiovascular

Cardiovascular side effects including cardiac irregularities, hypertension, myocardial infarction, hypotension (including orthostatic hypotension), palpitation, phlebitis, and syncope have been observed while taking carbidopa with other drugs such as levodopa, and with carbidopa-levodopa in combination product.

Gastrointestinal

Gastrointestinal side effects including abdominal pain, anorexia, bruxism, burning sensation of the tongue, constipation, dark saliva, development of duodenal ulcer, diarrhea, dry mouth, dyspepsia, dysphagia, flatulence, gastrointestinal bleeding, gastrointestinal pain, heartburn, hiccups, sialorrhea, taste alterations, and vomiting have been observed while taking carbidopa along with other drugs such as levodopa, and with carbidopa-levodopa combination product.

Hematologic

Hematologic side effects including hemolytic and nonhemolytic anemia, leukopenia, thrombocytopenia, and agranulocytosis have been observed while using carbidopa with other drugs such as levodopa, and with carbidopa-levodopa combination product.

Hypersensitivity

Hypersensitivity side effects such as angioedema, urticaria, pruritus, Henoch-Schonlein purpura, and bullous lesions, including pemphigus-like reactions, have been reported while carbidopa has been used with other drugs such as levodopa, and with carbidopa-levodopa combination product.

Metabolic

Metabolic side effects including edema, weight gain, and weight loss have been reported while carbidopa has been used with other drugs such as levodopa, and with carbidopa-levodopa combination product.

Musculoskeletal

Musculoskeletal side effects including back pain, leg pain, muscle cramps, shoulder pain, and dyskinesias such as choreiform, dystonic, and other involuntary movements have been reported when carbidopa has been used with other drugs such as levodopa, and with carbidopa-levodopa combination product.

Nervous system

Nervous system side effects including bradykinetic episodes ("on-off" phenomenon), confusion, decreased mental acuity, disorientation, euphoria, dizziness, dream abnormalities including nightmares, insomnia, malaise, faintness, extrapyramidal disorder, falling, ataxia, gait abnormalities, headache, increased tremor, memory impairment, muscle twitching, nervousness, numbness, paresthesia, peripheral neuropathy, somnolence, trismus, activation of latent Horner's syndrome, and increased libido have been reported when carbidopa has been used with other drugs such as levodopa, and with carbidopa-levodopa combination product.

Ocular

Ocular side effects including oculogyric crises, diplopia, blurred vision, dilated pupils, and blepharospasm have been reported when carbidopa has been used with other drugs such as levodopa, and with carbidopa-levodopa combination product. Blepharospasm could be an indication of excess dosage and dosage reduction should be considered.

Psychiatric

Psychiatric side effects including agitation, anxiety, psychotic episodes (including delusions, hallucinations, and paranoid ideation), depression with or without development of suicidal tendencies, and dementia have been reported when carbidopa has been used with other drugs such as levodopa, and with carbidopa-levodopa combination product.

Respiratory

Respiratory side effects including upper respiratory infection, dyspnea, pharyngeal pain, cough, and abnormal breathing patterns have been reported when carbidopa has been used with other drugs such as levodopa, and with carbidopa-levodopa combination product.

Genitourinary

Genitourinary side effects including priapism, dark urine, urinary frequency, urinary incontinence, urinary retention, and urinary tract infection have been reported while taking carbidopa with other drugs such as with levodopa, and with carbidopa-levodopa combination product.

Dermatologic

Dermatologic side effects including increased sweating, dark sweat, flushing, rash, alopecia, and malignant melanoma have been reported while taking carbidopa in combination with other drugs such as levodopa, and with carbidopa-levodopa combination product.

Other

Other side effects including hoarseness, hot flashes, neuroleptic malignant syndrome, and sense of stimulation have been reported when carbidopa has been used with other drugs such as levodopa, and with carbidopa-levodopa combination product.

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