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Carbidopa Pregnancy and Breastfeeding Warnings

Carbidopa is also known as: Lodosyn

Carbidopa Pregnancy Warnings

Carbidopa has been assigned to pregnancy category C by the FDA. Animal studies have failed to reveal evidence of teratogenicity in mice or rabbits at doses as high as 120 mg/kg/day. There are no controlled data in human pregnancy. Although levodopa crosses the human placental barrier, enters the fetus, and is metabolized, it was reported that carbidopa concentrations were minimal in fetal tissue. Carbidopa should only be given during pregnancy when there are no alternatives and benefit outweighs risk.

Carbidopa Breastfeeding Warnings

There are no data on the excretion of carbidopa into human milk. The manufacturer recommends that due to the potential for adverse reactions in nursing infants, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

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