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Captopril / hydrochlorothiazide Side Effects

For the Consumer

Applies to captopril / hydrochlorothiazide: oral tablet

In addition to its needed effects, some unwanted effects may be caused by captopril / hydrochlorothiazide. In the event that any of these side effects do occur, they may require medical attention.

Severity: Major

You should check with your doctor immediately if any of these side effects occur when taking captopril / hydrochlorothiazide:

More common:
  • Black, tarry stools
  • chest pain
  • chills
  • cough
  • fever
  • painful or difficult urination
  • shortness of breath
  • sore throat
  • sores, ulcers, or white spots on lips or in mouth
  • swollen glands
  • unusual bleeding or bruising
  • unusual tiredness or weakness
Less common:
  • Blurred vision
  • cloudy urine
  • confusion
  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
  • fast, pounding, or irregular heartbeat or pulse
  • sweating
Rare:
  • Arm, back or jaw pain or discomfort
  • bloody urine
  • chest discomfort
  • chest tightness or heaviness
  • decreased blood pressure
  • decreased frequency or amount of urine
  • dilated neck veins
  • increased need to urinate
  • increased thirst
  • irregular breathing
  • large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • loss of appetite
  • lower back or side pain
  • nausea
  • paleness or cold feeling in fingertips and toes
  • passing urine more often
  • problems in urination or increase in amount of urine
  • swelling of face, fingers, feet or lower legs
  • tingling or pain in fingers or toes when exposed to cold
  • troubled breathing
  • vomiting
  • weight gain
  • wheezing

Severity: Minor

Some of the side effects that can occur with captopril / hydrochlorothiazide may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Difficulty in moving
  • itching skin
  • muscle pain or stiffness
  • pain in joints
  • rash
Less common:
  • Change in taste
  • loss of taste

For Healthcare Professionals

Applies to captopril / hydrochlorothiazide: oral tablet

Gastrointestinal

Captopril:
Common (1% to 10%): Nausea, vomiting, gastric irritations, abdominal pain, diarrhea, constipation, dry mouth, peptic ulcer, aphthous ulcers
Rare (0.01% to 0.1%): Intestinal angioedema
Very rare (less than 0.01%): Glossitis, pancreatitis
Frequency not reported: Dyspepsia

Hydrochlorothiazide:
Frequency not reported: Sialadenitis, gastric irritation, diarrhea, constipation, pancreatitis, cramping, nausea, vomiting[Ref]

Nervous system

Captopril:
Common (1% to 10%): Taste impairment, dizziness, headache, paresthesias
Rare (0.01% to 0.1%): Drowsiness
Very rare (less than 0.01%): Cerebrovascular incidents
Frequency not reported: Syncope, ataxia, somnolence

Hydrochlorothiazide:
Frequency not reported: Paresthesia, lightheadedness, vertigo, dizziness, headache[Ref]

Dermatologic

Captopril:
Common (1% to 10%): Pruritus, rash, alopecia
Uncommon (0.1% to 1%): Angioedema
Very rare (less than 0.01%): Urticaria, Stevens-Johnson syndrome, erythema multiforme, photosensitivity, pemphigoid reactions, erythroderma, exfoliative dermatitis

Hydrochlorothiazide:
Frequency not reported: Cutaneous vasculitis, photosensitivity reactions, rash, cutaneous lupus erythematosus-like reactions, reactivation of cutaneous lupus erythematosus, urticaria, toxic epidermal necrolysis, purpura[Ref]

Other

Captopril:
Common (1% to 10%): Chest pain, malaise, fatigue
Very rare (less than 0.01%): Gynecomastia, fever
Frequency not reported: Asthenia

Hydrochlorothiazide:
Frequency not reported: Fever, weakness[Ref]

Cardiovascular

Captopril:
Common (1% to 10%): Tachycardia, palpitations
Uncommon (0.1% to 1%): Tachyarrhythmia, angina pectoris, hypotension, Raynaud's syndrome, flush, pallor, myocardial infarction, congestive heart failure
Very rare (less than 0.01%): Cardiac arrest, cardiogenic shock
Frequency not reported: Rhythm disturbances, orthostatic hypotension

Hydrochlorothiazide:
Frequency not reported: Postural hypotension, cardiac arrhythmias, vasculitis[Ref]

Respiratory

Captopril:
Common (1% to 10%): Cough, dyspnea
Very rare (less than 0.01%): Bronchospasm, rhinitis, allergic alveolitis/eosinophilic pneumonia

Hydrochlorothiazide:
Frequency not reported: Respiratory distress, pneumonitis, pulmonary edema[Ref]

Psychiatric

Captopril:
Common (1% to 10%): Sleep disorders, insomnia
Very rare (less than 0.01%): Confusion, depression
Frequency not reported: Nervousness

Hydrochlorothiazide:
Frequency not reported: Restlessness, depression, sleep disturbances[Ref]

Genitourinary

Captopril:
Common (1% to 10%): Proteinuria
Uncommon (0.1% to 1%): Polyuria, oliguria, urinary frequency
Very rare (less than 0.01%): Impotence

Hydrochlorothiazide:
Frequency not reported: Glycosuria[Ref]

Metabolic

Captopril:
Common (1% to 10%): Anorexia
Very rare (less than 0.01%): Hyperkalemia, hypoglycemia, serum potassium increased, serum sodium decreased
Frequency not reported: Symptomatic hyponatremia

Hydrochlorothiazide:
Frequency not reported: Anorexia, hyperglycemia, hyperuricemia, electrolyte imbalance, hyponatremia, hypokalemia, cholesterol increased, triglycerides increased, loss of appetite[Ref]

Renal

Captopril:
Uncommon (0.1% to 1%): Renal insufficiency, renal failure, nephrotic syndrome
Very rare (less than 0.01%): BUN increased, serum creatinine increased

Hydrochlorothiazide:
Frequency not reported: Renal dysfunction, interstitial nephritis[Ref]

Hematologic

Captopril:
Uncommon (0.1% to 1%): Eosinophilia
Very rare (less than 0.01%): Neutropenia/agranulocytosis, pancytopenia, anemia, thrombocytopenia, lymphadenopathy, hemoglobin decreased, hematocrit decreased, leukocytes decreased, thrombocytes decreased, erythrocyte sedimentation rate increased

Hydrochlorothiazide:
Frequency not reported: Leukopenia, neutropenia/agranulocytosis, thrombocytopenia, aplastic anemia, hemolytic anemia, bone marrow depression[Ref]

Immunologic

Captopril:
Uncommon (0.1% to 1%): Antinuclear antibody positive
Very rare (less than 0.01%): Autoimmune diseases
Frequency not reported: Anaphylactoid reactions

Hydrochlorothiazide:
Frequency not reported: Anaphylactic reactions[Ref]

Hepatic

Captopril:
Very rare (less than 0.01%): Impaired hepatic function and cholestasis including jaundice, hepatitis including necrosis, elevated liver enzymes and bilirubin

Hydrochlorothiazide:
Frequency not reported: Intrahepatic cholestatic jaundice[Ref]

Musculoskeletal

Captopril:
Very rare (less than 0.01%): Myalgia, arthralgia
Frequency not reported: Myasthenia

Hydrochlorothiazide:
Frequency not reported: Muscle spasm[Ref]

Ocular

Captopril:
Very rare (less than 0.01%): Blurred vision

Hydrochlorothiazide:
Frequency not reported: Xanthopsia, transient blurred vision, acute myopia, secondary acute angle-closure glaucoma[Ref]

References

1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. Capozide (hydrochlorothiazide-captopril)." Bristol-Myers Squibb, Princeton, NJ.

Not all side effects for captopril / hydrochlorothiazide may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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