captopril and hydrochlorothiazide (Oral route)
ACE inhibitors can cause injury or death to the developing fetus when used during the second and third trimesters. Stop therapy as soon as possible when pregnancy is detected .
Commonly used brand name(s)
In the U.S.
- Capozide 25/15
- Capozide 25/25
- Capozide 50/15
- Capozide 50/25
Available Dosage Forms:
Therapeutic Class: ACE Inhibitor/Thiazide Combination
Pharmacologic Class: ACE Inhibitor
Chemical Class: Thiazide
Uses For captopril and hydrochlorothiazide
Captopril and hydrochlorothiazide combination is used to treat high blood pressure (hypertension). High blood pressure adds to the work load of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys resulting in a stroke, heart failure, or kidney failure. Hypertension may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled .
Captopril works by blocking an enzyme in the body that is necessary to produce a substance that causes blood vessels to tighten. As a result, the blood vessels relax. Hydrochlorothiazide works by helping reduce the amount of salt and water in the body by acting on the kidneys to increase the flow of urine. Both of these medicines lower blood pressure and increase the supply of blood and oxygen to the heart .
captopril and hydrochlorothiazide is available only with your doctor's prescription .
Before Using captopril and hydrochlorothiazide
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For captopril and hydrochlorothiazide, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to captopril and hydrochlorothiazide or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies have not been performed on the relationship of age to the effects of captopril and hydrochlorothiazide combination in the pediatric population. Safety and efficacy have not been established .
No information is available on the relationship of age to the effects of captopril and hydrochlorothiazide combination in geriatric patients. However, elderly patients are more likely to have age-related kidney problems, which may require an adjustment of dose in patients receiving captopril and hydrochlorothiazide combination .
|1st Trimester||C||Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.|
|2nd Trimester||D||Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.|
|3rd Trimester||D||Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.|
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking captopril and hydrochlorothiazide, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using captopril and hydrochlorothiazide with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
Using captopril and hydrochlorothiazide with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Alteplase, Recombinant
- Arsenic Trioxide
- Candesartan Cilexetil
- Dabigatran Etexilate
- Doxorubicin Hydrochloride Liposome
- Interferon Alfa-2a
- Morphine Sulfate Liposome
- Olmesartan Medoxomil
- Vincristine Sulfate Liposome
Using captopril and hydrochlorothiazide with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Amtolmetin Guacil
- Bupivacaine Liposome
- Choline Salicylate
- Enalapril Maleate
- Ethacrynic Acid
- Flufenamic Acid
- Gold Sodium Thiomalate
- Ibuprofen Lysine
- Mefenamic Acid
- Niflumic Acid
- Salicylic Acid
- Sodium Salicylate
- Tiaprofenic Acid
- Tolfenamic Acid
Interactions with Food/Tobacco/Alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Other Medical Problems
The presence of other medical problems may affect the use of captopril and hydrochlorothiazide. Make sure you tell your doctor if you have any other medical problems, especially:
- Angioedema, history of—May increase the risk of this condition occurring again .
- Anuria (not able to pass urine)—captopril and hydrochlorothiazide should not be used in patients with this condition .
- Asthma, bronchial—captopril and hydrochlorothiazide may cause sensitivity reactions .
- Dehydration or
- Diarrhea or
- Heart failure or
- Hyponatremia (low sodium in the blood) or
- Kidney disease—These conditions may cause the blood pressure to fall too low with captopril and hydrochlorothiazide .
- Diabetes or
- Gout or
- Hyperuricemia (high uric acid in the blood) or
- Liver disease or
- Systemic lupus erythematosus (SLE)—These conditions may be made worse .
Proper Use of captopril and hydrochlorothiazide
In addition to the use of captopril and hydrochlorothiazide, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium. Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.
Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.
Remember that captopril and hydrochlorothiazide will not cure your high blood pressure but it does help control it. Therefore, you must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.
It is best to take captopril and hydrochlorothiazide on an empty stomach at least 1 hour before eating any food .
The dose of captopril and hydrochlorothiazide will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of captopril and hydrochlorothiazide. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
- For oral dosage form (tablets):
- For high blood pressure:
- Adults—1 or 2 tablets once a day.
- Children—Use and dose must be determined by your doctor .
- For high blood pressure:
If you miss a dose of captopril and hydrochlorothiazide, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Ask your healthcare professional how you should dispose of any medicine you do not use.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Precautions While Using captopril and hydrochlorothiazide
It is very important that your doctor check your progress at regular visits to make sure captopril and hydrochlorothiazide is working properly and to check for unwanted effects. Blood tests may be needed to check for unwanted effects .
Using captopril and hydrochlorothiazide while you are pregnant can harm your unborn baby. If you think you have become pregnant while using captopril and hydrochlorothiazide, tell your doctor right away .
Stop using captopril and hydrochlorothiazide and call your doctor right away if you have swelling of the face, arms, legs, eyes, lips, or tongue, or problems with swallowing or breathing. These are symptoms of a condition called angioedema .
Stop using captopril and hydrochlorothiazide and call your doctor right away if you have severe stomach pain. This could be a symptom of a condition called intestinal angioedema .
Tell your doctor immediately if you have any signs of infection such as chills, sore throat, or fever. These may be symptoms of an immune system condition called neutropenia .
If your symptoms do not improve within a few days or if they become worse, check with your doctor. Do not stop using captopril and hydrochlorothiazide unless your doctor tells you to .
You may experience lightheadedness during the first few days with captopril and hydrochlorothiazide. If this becomes severe and you faint, stop using captopril and hydrochlorothiazide and talk to your doctor right away .
captopril and hydrochlorothiazide may affect blood sugar levels. If you notice a change in the results of your blood or urine sugar tests, or if you have any questions, check with your doctor .
Check with your doctor right away if you have symptoms of jaundice (yellow skin or eyes) because these may be signs of a serious liver condition .
captopril and hydrochlorothiazide may increase the amount of potassium in your blood. Do not use salt substitutes containing potassium without first checking with your doctor .
Make sure any doctor or dentist who treats you knows that you are using captopril and hydrochlorothiazide. You may need to stop using captopril and hydrochlorothiazide several days before having surgery or medical tests .
captopril and hydrochlorothiazide Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:More common
- Black, tarry stools
- chest pain
- painful or difficult urination
- shortness of breath
- sore throat
- sores, ulcers, or white spots on lips or in mouth
- swollen glands
- unusual bleeding or bruising
- unusual tiredness or weakness
- Blurred vision
- cloudy urine
- dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
- fast, pounding, or irregular heartbeat or pulse
- Arm, back or jaw pain or discomfort
- bloody urine
- chest discomfort
- chest tightness or heaviness
- decreased blood pressure
- decreased frequency or amount of urine
- dilated neck veins
- increased need to urinate
- increased thirst
- irregular breathing
- large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- loss of appetite
- lower back or side pain
- paleness or cold feeling in fingertips and toes
- passing urine more often
- problems in urination or increase in amount of urine
- swelling of face, fingers, feet or lower legs
- tingling or pain in fingers or toes when exposed to cold
- troubled breathing
- weight gain
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- Difficulty in moving
- itching skin
- muscle pain or stiffness
- pain in joints
- Change in taste
- loss of taste
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
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