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Calcitriol topical Side Effects

Not all side effects for calcitriol topical may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to calcitriol topical: ointment

Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Mild skin discomfort at the application site.

Seek medical attention right away if any of these SEVERE side effects occur while taking calcitriol topical:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); new or worsening skin irritation (eg, blistered skin, flushing, itching, burning, severe discomfort or redness); symptoms of hypercalcemia (weakness, nausea, constipation, excessive thirst, confusion, fast, slow, or irregular heartbeat).

For Healthcare Professionals

Applies to calcitriol topical: topical ointment


Metabolic side effects have included hypercalcemia which was reported in 24% of the subjects exposed to active drug and 16% of the subjects exposed to the vehicle.[Ref]

In the subjects reported to have hypercalcemia, the elevations were less than 10% above the upper limit of normal.[Ref]


Other side effects have included laboratory test abnormality (8%).[Ref]


Dermatologic side effects have included psoriasis (4%), skin discomfort (3%), and pruritus (up to 3%). Acute blistering dermatitis, erythema, pruritus, skin discomfort, and skin burning sensation have been reported during postmarketing experience.[Ref]

The drug was being used in the treatment of psoriasis.[Ref]


Genitourinary side effects have included urine abnormality (4%) and hypercalciuria (3%).[Ref]


Kidney stones were reported in three subjects and confirmed in two.[Ref]

Renal side effects have included kidney stones.[Ref]


1. "Product Information. Vectical (calcitriol topical)." Galderma Laboratories Inc, Cranbury, NJ.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

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