Calcitriol use while Breastfeeding

Drugs containing Calcitriol: Rocaltrol, Vectical, Calcijex

Calcitriol Levels and Effects while Breastfeeding

Summary of Use during Lactation

Calcitriol is the normal physiologically active form of vitamin D, 1,25-dihydroxyvitamin D. Limited data indicate that its use in nursing mothers in appropriately adjusted doses does not affect the breastfed infant. If calcitriol is required by the mother, it is not a reason to discontinue breastfeeding. Calcitriol and calcium dosage requirements are usually reduced during lactation in women with hypoparathyroidism.[1][2][3][4][5][6][7][8] The American Academy of Pediatrics recommends the administration of a minimum of 400 IU of vitamin D daily to all infants, children and adolescents.[9]

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

A woman with hypoparathyroidism breastfed her infant from week 1 to week 32 postpartum while taking calcitriol. The dose was initially 0.5 mcg daily, but was decreased to 0.25 mcg daily after 8 weeks. The infant thrived during breastfeeding and had normal serum calcium levels at 1 and 3 weeks and 3 months of age.[3]

A woman breastfed infants after two pregnancies while taking calcitriol in doses of 0.75 and 1 mcg daily. There were no reports of adverse reactions.[10]

A woman breastfed her newborn infant for 9 days while taking calcitriol 0.5 mcg three times daily. Calcitriol was stopped at that time because of hypercalcemia, but restarted at 40 days postpartum in low doses that were gradually increased until the prepregnancy dosage of 1.5 mcg daily was reached just before weaning at 12.5 months postpartum.[5]

A woman with discoid lupus was taking calcitriol 0.25 mcg every 2 days and several other medications concurrently. Her infant was breastfed for 12 months and followed up at 15 months of age. No adverse effects were reported during breastfeeding and the infant was growing and developing normally at 15 months of age.[11]

Possible Effects on Lactation

Relevant published information was not found as of the revision date.

References

1. Sweeney LL, Malabanan AO, Rosen H. Decreased calcitriol requirements during pregnancy and lactation, with a window of increased requirements immediately postpartum. Endocr Pract. 2010;1-11. PMID: 20061285

2. Cathebras P, Cartry O, Sassolas G, Rousset H. [Hypercalcemia induced by lactation in 2 patients with treated hypoparathyroidism]. Rev Med Interne. 1996;17:675-6. PMID: 8881196

3. Caplan RH, Wickus GG. Reduced calcitriol requirements for treating hypoparathyroidism during lactation. A case report. J Reprod Med. 1993;38:914-8. PMID: 8277494

4. Caplan RH, Beguin EA. Hypercalcemia in a calcitriol-treated hypoparathyroid woman during lactation. Obstet Gynecol. 1990;76 (3 Pt 2):485-9. PMID: 2381632

5. Cundy T, Haining SA, Guilland-Cumming DF et al. Remission of hypoparathyroidism during lactation: evidence for a physiological role for prolactin in the regulation of vitamin D metabolism. Clin Endocrinol (Oxf). 1987;26:667-74. PMID: 3665123

6. Mather KJ, Chik CL, Corenblum B. Maintenance of serum calcium by parathyroid hormone-related peptide during lactation in a hypoparathyroid patient. J Clin Endocrinol Metab. 1999;84:424-7. PMID: 10022395

7. Rude RK, Haussler MR, Singer FR. Postpartum resolution of hypocalcemia in a lactating hypoparathyroid patient. Endocrinol Jpn. 1984;31:227-33. PMID: 6548698

8. Krysiak R, Kobielusz-Gembala I, Okopien B. Hypoparathyroidism in pregnancy. Gynecol Endocrinol. 2011;27:529-32. PMID: 21463229

9. Wagner CL, Greer FR. Prevention of rickets and vitamin D deficiency in infants, children, and adolescents. Pediatrics. 2008;122:1142-52. PMID: 18977996

10. Callies F, Arlt W, Scholz HJ et al. Management of hypoparathyroidism during pregnancy--report of twelve cases. Eur J Endocrinol. 1998;139:284-9. PMID: 9758437

11. Moretti ME, Verjee Z, Ito S, Koren G. Breast-feeding during maternal use of azathioprine. Ann Pharmacother. 2006;40:2269-72. PMID: 17132809

Calcitriol Identification

Substance Name

Calcitriol

CAS Registry Number

32222-06-3

Drug Class

  • Bone Density Conservation Agents
  • Vitamins
  • Vitamin D

Administrative Information

LactMed Record Number

792

Information from the National Library of Medicine's LactMed Database.

Last Revision Date

2013-09-07

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

See Also...

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