Arzerra Side Effects
Generic Name: ofatumumab
Note: This document contains side effect information about ofatumumab. Some of the dosage forms listed on this page may not apply to the brand name Arzerra.
Some side effects of Arzerra may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to ofatumumab: intravenous solution
Along with its needed effects, ofatumumab (the active ingredient contained in Arzerra) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking ofatumumab:More common
- Black, tarry stools
- bloating or swelling of the face, arms, hands, lower legs, or feet
- body aches or pain
- chest pain
- cough or hoarseness
- cough producing mucus
- difficult or labored breathing
- ear congestion
- facial swelling
- fast heartbeat
- increased sweating
- loss of voice
- lower back or side pain
- nasal congestion
- nausea or vomiting
- painful blisters on the trunk of the body
- painful or difficult urination
- pale skin
- rapid weight gain
- rapid, shallow breathing
- runny nose
- skin rash
- sore throat
- tightness in the chest
- tingling of the hands or feet
- troubled breathing
- troubled breathing with exertion
- ulcers, sores, or white spots in the mouth
- unusual bleeding or bruising
- unusual tiredness or weakness
- unusual weight gain or loss
- Blurred vision
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- fast, pounding, or irregular heartbeat or pulse
- pounding in the ears
- slow or fast heartbeat
Some side effects of ofatumumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- Back pain
- hives or welts
- muscle aches
- redness of the skin
- trouble sleeping
- Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
- muscle spasms
- pain or tenderness around the eyes and cheekbones
For Healthcare Professionals
Applies to ofatumumab: intravenous solution
Sepsis included sepsis, neutropenic sepsis, bacteremia, and septic shock.
General side effects including pyrexia (20%), fatigue (15%), peripheral edema (9%), chills (8%), sepsis (8%), and herpes zoster (6%) have been reported.
A total of 108 patients (70%) experienced bacterial, viral, or fungal infections. A total of 45 patients (29%) experienced grade 3 infections, of which 19 (12%) were fatal.
Infusion reactions occurred in 44% of patients on the day of the first infusion (300 mg), 29% on the day of the second infusion (2,000 mg), and less frequently during subsequent infusions.
Hematologic side effects including anemia (16%) have been reported.
Out of 108 patients with normal neutrophil counts at baseline, 45 (42%) developed grade 3 neutropenia. Nineteen (18%) developed grade 4 neutropenia. Some patients experienced new onset grade 4 neutropenia over two weeks in duration.
Pneumonia included pneumonia, lung infection, lobar pneumonia, and bronchopneumonia.
Respiratory side effects including pneumonia (23%), cough (19%), dyspnea (14%), upper respiratory tract infection (11%), bronchitis (11%), nasopharyngitis (8%), and sinusitis (5%) have been reported.
Gastrointestinal side effects including diarrhea (18%) and nausea (11%) have been reported.
Rash included rash, macular rash, and vesicular rash.
Dermatologic side effects including rash (14%), urticaria (8%), and hyperhidrosis (5%) have been reported.
Musculoskeletal side effects including back pain (8%) and muscle spasms (5%) have been reported.
Psychiatric side effects including insomnia (7%) have been reported.
Nervous system side effects including headache (6%) have been reported.
Cardiovascular side effects including hypertension (5%), hypotension (5%), and tachycardia (5%) have been reported.
More about Arzerra (ofatumumab)
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