Amlodipine / Benazepril Side Effects

Medically reviewed by Drugs.com. Last updated on Aug 12, 2023.

Applies to amlodipine / benazepril: oral capsule.

Important warnings This medicine can cause some serious health issues

Oral route (capsule)

Discontinue amlodipine besylate/benazepril hydrochloride as soon as possible if pregnancy is detected.

This drug can cause injury and death to the fetus.

Serious side effects

Along with its needed effects, amlodipine / benazepril may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking amlodipine / benazepril:

Less common

• confusion
• dizziness, lightheadedness, or fainting
• fast or irregular heartbeat
• nervousness
• numbness or tingling in the hands, feet, or lips
• swelling of the ankles, feet, or lower legs
• weakness or heaviness of the legs

Rare

• bleeding gums
• chills
• fever
• nausea or vomiting
• nosebleeds
• pale skin
• sores, ulcers, or white spots on the lips, tongue, or inside the mouth
• stomach pain or bloating with fever, nausea, or vomiting
• swelling of the face, mouth, hands, or feet
• trouble with swallowing or breathing (sudden) or hoarseness
• unusual bleeding or bruising
• unusual tiredness or weakness
• yellow eyes or skin

Incidence not known

• chest pain
• heartburn
• pain or burning in the throat

Other side effects

Some side effects of amlodipine / benazepril may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

• cough (dry and continuous)
• feeling of warmth
• redness of the face, neck, arms, and occasionally upper chest
• sleepiness

Incidence not known

• belching
• blistering, crusting, irritation, itching, or reddening of the skin
• body aches or pain
• cracked, dry, or scaly skin
• decreased interest in sexual intercourse
• difficulty having a bowel movement
• frequent urination
• inability to have or keep an erection
• increased volume of pale, dilute urine
• indigestion
• lack or loss of strength
• loss in sexual ability, desire, drive, or performance
• muscle or bone pain
• shakiness in the legs, arms, hands, or feet
• stomach discomfort or upset
• sudden sweating
• swelling
• tender, swollen glands in the neck
• trembling or shaking of the hands or feet
• trouble with sleeping
• voice changes

For healthcare professionals

Applies to amlodipine / benazepril: oral capsule.

General

The most common side effects were cough, headache, dizziness, and edema.^[Ref]

Nervous system

• Common (1% to 10%): Headache, dizziness
• Frequency not reported: Tremor

Amlodipine:

• Common (1% to 10%): Headache, dizziness
• Postmarketing reports: Dysgeusia, hypoesthesia, paresthesia, syncope, peripheral neuropathy, hypertonia

Benazepril:

• Common (1% to 10%): Headache, dizziness
• Postmarketing reports: Paresthesia, dysgeusia^[Ref]

Respiratory

• Common (1% to 10%): Cough
• Frequency not reported: Pharyngitis

Amlodipine:

• Uncommon (0.1% to 1%): Cough
• Postmarketing reports: Rhinitis

Benazepril:

• Common (1% to 10%): Cough^[Ref]

Other

• Common (1% to 10%): Edema
• Frequency not reported: Asthenia, fatigue

Amlodipine:

• Common (1% to 10%): Edema
• Postmarketing reports: Malaise

Benazepril:

• Uncommon (0.1% to 1%): Edema^[Ref]

Amlodipine-induced peripheral edema is dose dependent. Benazepril reduces the incidence of edema when added to amlodipine.^[Ref]

Genitourinary

• Frequency not reported: Impotence, polyuria

Amlodipine:

• Postmarketing reports: Micturition disorder, nocturia, erectile dysfunction^[Ref]

Gastrointestinal

• Frequency not reported: Dry mouth, nausea, abdominal pain, constipation, diarrhea, dyspepsia, esophagitis

Amlodipine:

• Postmarketing reports: Gingival hyperplasia, gastritis^[Ref]

Musculoskeletal

• Frequency not reported: Back pain, musculoskeletal pain, cramps, muscle cramps

Amlodipine:

• Postmarketing reports: Muscle spasms, arthralgia

Benazepril:

• Postmarketing reports: Arthralgia, arthritis, myalgia^[Ref]

Dermatologic

• Frequency not reported: Rash, skin nodule, dermatitis

Amlodipine:

• Postmarketing reports: Hyperhidrosis, pruritus, skin discoloration, urticaria, erythema multiform

Benazepril:

• Postmarketing reports: Stevens-Johnson syndrome, pemphigus, pruritus, photosensitivity reaction^[Ref]

Psychiatric

• Frequency not reported: Insomnia, nervousness, anxiety, libido decreased^[Ref]

Cardiovascular

• Frequency not reported: Flushing, hot flashes

Amlodipine:

• Postmarketing reports: Tachycardia, hypotension, vasculitis

Benazepril:

• Postmarketing reports: Orthostatic symptoms, hypotension, angina pectoris, arrhythmia^[Ref]

Ocular

Amlodipine:

• Postmarketing reports: Visual impairment, diplopia

Benazepril:

• Postmarketing reports: Impaired vision^[Ref]

Metabolic

• Frequency not reported: Hypokalemia

Amlodipine:

• Postmarketing reports: Hyperglycemia, weight decrease or gain^[Ref]

Immunologic

Amlodipine:

• Postmarketing reports: Allergic reaction^[Ref]

Renal

• Postmarketing reports: Serum creatinine increased, BUN increased, renal impairment^[Ref]

Benazepril

Hematologic

• Frequency not reported: Neutropenia

Amlodipine:

• Postmarketing reports: Leucocytopenia

Benazepril:

• Postmarketing reports: Hemolytic anemia, thrombocytopenia, agranulocytosis, neutropenia^[Ref]

Hepatic

Amlodipine:

• Postmarketing reports: Jaundice, hepatic enzyme elevations

Benazepril:

• Postmarketing reports: Pancreatitis^[Ref]

Further information

Amlodipine/benazepril side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer