Actimmune Side Effects

Generic Name: interferon gamma-1b

Note: This page contains information about the side effects of interferon gamma-1b. Some of the dosage forms included on this document may not apply to the brand name Actimmune.

Not all side effects for Actimmune may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to interferon gamma-1b: solution

Along with its needed effects, interferon gamma-1b (the active ingredient contained in Actimmune) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking interferon gamma-1b:

Rare
  • Black, tarry stools
  • blood in urine or stools
  • confusion
  • cough or hoarseness
  • loss of balance control
  • lower back or side pain
  • mask-like face
  • painful or difficult urination
  • pinpoint red spots on skin
  • shuffling walk
  • stiffness of arms or legs
  • trembling and shaking of hands and fingers
  • trouble in speaking or swallowing
  • trouble in thinking or concentrating
  • trouble in walking
  • unusual bleeding or bruising

Some side effects of interferon gamma-1b may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Aching muscles
  • diarrhea
  • fever and chills
  • general feeling of discomfort or illness
  • headache
  • nausea or vomiting
  • skin rash
  • unusual tiredness
Less common
  • Back pain
  • dizziness
  • joint pain
  • loss of appetite
  • weight loss

For Healthcare Professionals

Applies to interferon gamma-1b: subcutaneous solution

General

General flu-like side effects have been reported most frequently. These have included fever (52%), headache (33%), chills (14%), fatigue (14%), myalgia (6%), and arthralgia (2%). Chest discomfort has been reported.

Gastrointestinal

Gastrointestinal side effects have been reported frequently. These have included diarrhea (14%), vomiting (13%), and nausea (10%). Gastrointestinal bleeding has been reported rarely.

Dermatologic

Dermatologic side effects have included rash (17%).

Local

Local side effects have included erythema or tenderness at the site of injection (14%).

Cardiovascular

Cardiovascular side effects have been reported rarely. These have included hypotension, syncope, tachyarrhythmia, heart block, heart failure, and myocardial infarction.

Nervous system

Nervous system side effects have been reported rarely. These have included confusion, disorientation, gait disturbance, Parkinsonian symptoms, seizure, hallucinations, and transient ischemic attacks.

Respiratory

Respiratory side effects have included tachypnea, bronchospasm, and interstitial pneumonitis.

Hematologic

Hematologic side effects have been reported rarely. These have included deep venous thrombosis and pulmonary embolism.

Renal

Renal side effects have included renal insufficiency which was reversible.

Metabolic

Metabolic side effects have included hyponatremia, hyperglycemia, and hypertriglyceridemia.

Immunologic

Immunologic side effects have included increased autoantibodies and lupus-like syndrome.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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