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Pronunciation: try-PRO-lih-deen
Class: Alkylamine, nonselective

Trade Names

- Liquid 1.25 mg per 5 mL as triprolidine hydrochloride

Zymine XR
- Suspension, oral 2.5 mg per 5 mL as triprolidine tannate


Competitively blocks histamine at H 1 receptor sites.

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Plasma t ½ is about 3 to 3.3 h.

Indications and Usage

Symptomatic relief of perennial and season allergic rhinitis; vasomotor rhinitis; allergic conjunctivitis caused by inhalant allergens and foods; mild uncomplicated allergic skin manifestations of urticaria and angioedema.


Standard considerations.

Dosage and Administration

Adults and Children (12 yr of age and older)

PO 2.5 mg every 4 to 6 h (max, 10 mg per 24 h).

Children (6 to 12 yr of age)

PO 1.25 mg every 4 to 6 h (max, 5 mg per 24 h).

Children (4 to 6 yr of age)

PO 0.94 mg every 4 to 6 h (max, 3.75 mg per 24 h).

Children (2 to 4 yr of age)

PO 0.625 mg every 4 to 6 h (max, 2.5 mg per 24 h).

Children (4 mo to 2 yr of age)

PO 0.31 mg every 4 to 6 h (max, 1.25 mg per 24 h).

Zymine XR
Adults and Children (12 yr of age and older)

PO 5 mg every 12 h (max, 10 mg per 24 h).

Children (6 to 12 yr of age)

PO 2.5 mg every 12 h (max, 5 mg per 24 h).

Children (2 to 6 yr of age)

PO 1.25 mg every 12 h (max, 2.5 mg per 24 h).


Store syrup at controlled room temperature (59° to 86°F).

Drug Interactions

Alcohol, CNS depressants (eg, narcotics, sedatives)

Additive CNS depression possible.


Anticholinergic effects may increase.

Laboratory Test Interactions

In skin testing procedures, may prevent or diminish otherwise positive reaction to dermal reactivity indicators.

Adverse Reactions


Orthostatic hypotension; palpitations; tachycardia; faintness.


Drowsiness (often transient); sedation; dizziness; faintness; disturbed coordination; excitation; headache; nervousness.


Blurred vision; nasal stuffiness; dry mouth, nose, and throat; sore throat.


Anorexia; epigastric distress; nausea; vomiting; diarrhea; constipation; change in bowel habits.


Dysuria; polyuria; urinary retention.


Increased appetite; weight gain.


Thickening of bronchial secretions.


Heartburn; hypersensitivity reactions; photosensitivity.



Category C .


Because of the possible passage of the ingredients into breast milk, this product should not be given to breast-feeding mothers.


Overdosage may cause hallucinations, convulsions, and death. Antihistamines may diminish mental alertness. In young children, triprolidine may produce paradoxical excitation.


Greater likelihood of dizziness, excessive sedation, syncope, toxic confusional states, and hypotension in patients older than 60 yr of age. Dosage reduction may be required.

Special Risk Patients

Use drug with caution in patients with predisposition to urinary retention, history of bronchial asthma, increased IOP, hyperthyroidism, sleep apnea, CV disease, or hypertension. Use with considerable caution in patients with narrow-angle glaucoma, stenosing peptic ulcer, pyloroduodenal obstruction, symptomatic prostatic hypertrophy, or bladder neck obstruction.

Respiratory disease

Generally not recommended to treat lower respiratory tract symptoms, including asthma.



CNS depression, CNS stimulation, hypotension, respiratory depression, coma, seizures.

Patient Information

  • Advise patient or caregiver to take or administer each dose without regard to meals but to take or administer with food if stomach upset occurs.
  • Advise patient or caregiver to measure and administer prescribed dose using dosing syringe, dosing spoon, or dosing cup.
  • Advise patient that if a dose is missed to take it as soon as possible unless it is nearing time for the next scheduled dose, then advise patient to skip the missed dose and take the next dose at the regularly scheduled time. Caution patient not to double the dose to catch up.
  • Advise patient that if allergy symptoms are not controlled not to increase the dose of medication or frequency of use but to inform health care provider. Caution patient that larger doses or more frequent dosing does not increase effectiveness and may cause excessive drowsiness or other adverse reactions.
  • Instruct patient to stop taking drug and immediately report any of these symptoms to health care provider: persistent dizziness; excessive drowsiness; severe dry mouth, nose, or throat; flushing; unexplained shortness of breath or difficulty breathing; unusual tiredness or weakness; sore throat, fever, or other signs of infection; bleeding or unusual bruising; fast or irregular heartbeat; excitability, confusion, or changes in thinking or behavior; chest tightness; or difficulty urinating.
  • Advise patient that medication may cause drowsiness or dizziness and not to drive or perform other activities requiring mental alertness until tolerance is determined.
  • Advise patient to take sips of water, suck on ice chips or sugarless hard candy, or chew sugarless gum if dry mouth occurs.
  • Caution patient that alcohol and other CNS depressants (eg, sedatives) will have additional sedative effects if taken with triprolidine.
  • Caution patient not to take any OTC antihistamines while taking this medication unless advised by health care provider.
  • Caution patient that medication may cause sensitivity to sunlight and to avoid excessive exposure to the sun or ultraviolet light (eg, tanning booths) and to wear protective clothing and use sunscreens until tolerance is determined.
  • If patient is to have allergy skin testing, advise patient not to take the medication for at least 4 days before the skin testing.

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