Pemetrexed

Trade Names:
Alimta
- Injection 500 mg

Pharmacology

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As a treatment for...	Avg User Ratings [?]
Non-Small Cell Lung Cancer	Be the first to rate it 0 comments
Malignant Pleural Mesothelioma	Be the first to rate it 0 comments

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Disrupts folate-dependent metabolic processes essential for cell replication.

Pharmacokinetics

Distribution

Vd is about 16.1 L. Protein binding approximately 81%.

Metabolism

Not appreciably metabolized.

Elimination

Primarily eliminated in the urine. Elimination t _½ is 3.5 h.

Special Populations

Cl decreases and AUC increases as renal function decreases.

Indications and Usage

In combination with cisplatin for the treatment of malignant pleural mesothelioma in patients whose disease is unresectable or who are otherwise not candidates for curative surgery; as a single agent for the treatment of locally advanced or metastatic non-small cell lung cancer after prior chemotherapy.

Contraindications

Standard considerations.

Dosage and Administration

IV Recommended dose is 500 mg/m ² infused over 10 min on day 1 of each 21-day cycle.

IV Reduce the dose of pemetrexed to 75% of previous dose in patients with nadir absolute neutrophil count (ANC) below 500/mm ³ and nadir platelets at least 50,000/mm ³ , any grade 3 or 4 toxicities (except mucositis), any diarrhea requiring hospitalization or grade 3 or 4 diarrhea. Reduce the dose to 50% of previous dose in patients with nadir platelets below 50,000/mm ³ regardless of nadir ANC or grade 3 or 4 mucositis. Discontinue immediately if grade 3 or 4 neurotoxicity occurs or if a patient experiences any hematologic or nonhematologic grade 3 or 4 toxicity after 2 dose reductions.

General Advice

• For IV infusion only. Not for intradermal, subcutaneous, IM, IV bolus, or intra-arterial administration.
• Administer corticosteroid (eg, dexamethasone day before, day of, and day after infusion) as prescribed to reduce incidence and severity of cutaneous reactions.
• Follow institutional procedures for handling, administration, and disposal of anticancer drugs.
• Reconstitute powder for injection with 20 mL preservative free 0.9% sodium chloride injection. Gently swirl until completely dissolved. Reconstituted solution contains 25 mg/mL of pemetrexed. Further dilute prescribed amount of reconstituted solution to 100 mL with preservative free sodium chloride injection and administer as IV infusion over 10 min.
• Do not administer if particulate matter or cloudiness is noted. A slight yellow or green-yellow coloration is normal and of no concern.
• Discard unused portions of vial. Do not save any unused portions for future use.
• Do not mix with any other medications or diluents.
• If pemetrexed solution contacts the skin, wash the skin immediately and thoroughly with soap and water. If pemetrexed contacts mucous membranes, flush thoroughly with water.

Storage/Stability

Store unopened vials at controlled room temperature (59° to 86°F). Reconstituted solution should be used immediately or used within 24 h if stored in refrigerator (36° to 46°F) or at controlled room temperature. Discard solution if not used within 24 h.

Drug Interactions

May delay Cl of pemetrexed.

Patients should interrupt NSAID dosing for at least 5 days before (2 days for NSAIDs with short elimination half-lives in patients with mild to moderate renal insufficiency), the day of, and 2 days following pemetrexed administration.

Calcium (including lactated Ringer's injection and Ringer's injection).

Laboratory Test Interactions

None well documented.

Adverse Reactions

Percentages of adverse reactions reported are for all grades of toxicity with patients receiving pemetrexed plus cisplatin.

Cardiovascular

Thrombosis/embolism (7%).

CNS

Fatigue (80%); neuropathy (17%); mood alteration/depression (14%).

Dermatologic

Rash/desquamation (22%).

GI

Nausea (84%); vomiting (58%); constipation (44%); anorexia (35%); stomatitis/ pharyngitis (28%); diarrhea (26%); esophagitis/dysphagia/odynophagia (6%).

Hematologic-Lymphatic

Neutropenia (58%); leukopenia (55%); anemia (33%); thrombocytopenia (27%).

Hypersensitivity

Allergic reaction/hypersensitivity (2%).

Metabolic-Nutritional

Dehydration (7%).

Renal

Creatinine elevation (16%); renal failure (2%).

Respiratory

Dyspnea (66%).

Miscellaneous

Chest pain (40%); fever (17%); infection without neutropenia (11%); infection with grade 3 or 4 neutropenia (6%); febrile neutropenia (1%).

Precautions

Pregnancy

Category D .

Lactation

Undetermined. Not recommended.

Children

Safety and efficacy not established.

Renal Function

Do not administer to patients with CrCl less than 45 mL/min.

Bone marrow suppression

Suppression of bone marrow function, manifested by neutropenia, thrombocytopenia, and anemia may occur.

Hematologic and GI toxicity

Folic acid and vitamin B ₁₂ supplementation should be taken to reduce treatment-related hematologic and GI toxicity. Ensure patient is taking low dose folic acid supplement, or multivitamin with folic acid, daily, starting 7 days before first dose of pemetrexed, during treatment, and for 21 days following last dose of pemetrexed. Ensure patient receives 1 IM injection of vitamin B ₁₂ during the week preceding the first dose of pemetrexed and then every 3 cycles thereafter. Subsequent doses may be administered the same day as pemetrexed.

Overdosage

Symptoms

Neutropenia, anemia, thrombocytopenia, mucositis, rash, infection (with or without fever), diarrhea.

Patient Information

• Advise patient, family, or caregiver that medication will be prepared and administered by health care professional in a health care setting.
• Review dosing schedule with patient, family, or caregiver.
• Instruct patient to carefully follow premedication orders for folic acid, vitamin B ₁₂ supplementation, and corticosteroid as ordered to reduce toxic effects of chemotherapy.
• Caution patient with mild renal insufficiency (CrCl from 45 to 79 mL/min) to avoid taking short-acting NSAIDs (eg, ibuprofen) for a period of 2 days before, the day of, and for 2 days following administration of pemetrexed.
• Caution patient with mild renal insufficiency (CrCl from 45 to 79 mL/min) to avoid taking long-acting NSAIDs (eg, piroxicam) for a period of 5 days before, the day of, and for 2 days following administration of pemetrexed.
• Advise patient, family, or caregiver to immediately report any of the following to health care provider: fever, chills, or other signs of infection; bleeding or unusual bruising; paleness; pain, redness, or swelling at injection site.
• Advise patient, family, or caregiver to report any of the following to health care provider: persistent nausea, vomiting, diarrhea, or appetite loss; sores in mouth; persistent or worsening general body weakness or fatigue; or any other bothersome symptom or feeling.
• Caution women of childbearing potential to avoid becoming pregnant during therapy.

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