Dorzolamide
Pronunciation: (dore-ZOLE-uh-mide)Class: Carbonic anhydrase inhibitor
Trade Names:
Trusopt
- Solution 2%
Pharmacology
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Inhibits carbonic anhydrase enzyme, reducing rate of aqueous humor formation and thus lowering IOP.
Indications and Usage
Treatment of elevated IOP in patients with ocular hypertension or open-angle glaucoma.
Contraindications
Hypersensitivity to other sulfonamides.
Dosage and Administration
AdultsOphthalmic One drop in affected eye(s) 3 times daily.
General Advice
- To avoid contamination, do not touch tip of container to any surface or to eye structures.
- Gently apply pressure over nasolacrimal drainage system for 1 to 2 min after administration.
- If used concomitantly with other topical ophthalmic drug products, wait 5 min between administering medications.
Storage/Stability
Store at room temperature; protect from light.
Drug Interactions
None well documented.
Laboratory Test Interactions
None well documented.
Adverse Reactions
CNS
Headache.
EENT
Ocular burning, stinging or discomfort; superficial punctate keratitis; blurred vision; tearing; conjunctivitis; ocular dryness; photophobia; ocular allergic reaction.
Miscellaneous
Nausea; bitter taste.
Precautions
MonitorNote baseline IOP before starting medication and monitor periodically during long-term treatment. |
Pregnancy
Category C .
Lactation
Unknown.
Children
Safety and efficacy not established.
Renal Function
Not recommended for use in patients with severe renal function impairment.
Hepatic Function
Use with caution.
Bacterial keratitis
Can occur by using contaminated eye drops.
Concomitant use of oral carbonic anhydrase inhibitors
Not recommended.
Contact lenses
Do not administer while wearing soft contact lenses; preservative may be absorbed by soft contact lenses.
Overdosage
Symptoms
Electrolyte imbalance, acidotic state, possible CNS effects.
Patient Information
- Instruct patient in proper administration of eye drop medications.
- Instruct patient about the need to keep the tip of the dropper clean to prevent eye infections.
- Inform patient that eye drops commonly produce transient stinging or discomfort upon administration, and to notify health care provider if they are severe.
- Stress need to return to health care provider frequently for monitoring of eye pressure.
- Inform patient not to wear soft contact lenses while using this medication.
- Inform patient that they may experience a bitter taste in mouth immediately after administration.
- Explain the need to be cautious when driving or participating in activities requiring close hand-eye coordination.
- Instruct patient to notify health care provider if any symptoms of eye infection (ie, burning, redness, itching, possible discharge) occur.
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dorzolamide ophthalmic Drug Interactions
Compare Dorzolamide with other medications for the treatment of:
Glaucoma, Open Angle, Intraocular Hypertension
