Chlorzoxazone
Pronunciation: (klor-ZOX-uh-zone)Class: Skeletal muscle relaxant, centrally acting
Trade Names:
Paraflex
- Caplets 250 mg
Trade Names:
Parafon Forte DSC
- Caplets 500 mg
Trade Names:
Remular-S
- Tablets 250 mg
Pharmacology
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Action may be related to its sedative properties or to inhibition of reflex arcs at spinal cord and subcortical levels of brain.
Pharmacokinetics
Absorption
T max is 1 to 2 h.
Metabolism
Rapidly metabolized.
Elimination
Excreted in the urine as glucuronide conjugate. Less than 1% is excreted in the urine as unchanged drug. The t ½ is about 60 min.
Onset
1 h.
Duration
3 to 4 h.
Indications and Usage
Relief of discomfort associated with painful musculoskeletal conditions.
Contraindications
Standard considerations.
Dosage and Administration
AdultsPO Initial (for acute pain): 500 mg 3 or 4 times daily; increase to 750 mg if needed. As improvement occurs, reduce dose; 250 mg 3 or 4 times daily is usually sufficient.
General Advice
Give with meals to avoid GI upset.
Drug Interactions
Alcohol and other CNS depressantsAdditive CNS depressant effects may occur.
Laboratory Test Interactions
None well documented.
Adverse Reactions
CNS
Drowsiness; dizziness; lightheadedness; malaise; overstimulation.
Dermatologic
Allergic-type skin rashes; petechiae.
GI
GI disturbances.
Genitourinary
Urine discoloration (orange or purple red).
Hepatic
Drug-induced hepatitis.
Miscellaneous
Hypersensitivity (eg, angioneurotic edema; anaphylaxis).
Precautions
Pregnancy
Pregnancy category undetermined.
Lactation
Undetermined.
Hepatic Function
Avoid use in patients with liver impairment; discontinue if signs of dysfunction occur.
Hazardous Tasks
May impair ability to perform tasks requiring mental or physical coordination or dexterity, including driving. Drowsiness is very common.
Overdosage
Symptoms
Nausea, vomiting, diarrhea, drowsiness, dizziness, lightheadedness, malaise, sluggishness, loss of muscle tone, decreased deep tendon reflex, respiratory depression.
Patient Information
- Instruct patient to inform health care provider of any urticaria, redness or itching.
- Tell patient to report to health care provider any yellowing of skin or eyes.
- Advise patient that drug may cause drowsiness and to use caution while driving or performing other tasks that require mental alertness.
- Advise patient to avoid intake of alcoholic beverages and other medications that cause drowsiness while taking product.
- Advise patient to notify health care provider before discontinuing medication.
- Inform patient to take a missed dose as soon as possible, unless several hours have passed. Advise patient not to double doses.
- Inform patient urine may turn orange or purple-red while taking this medication.
- Instruct patient to take with meals to avoid GI upset.
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