Sea Buckthorn

Scientific Name(s): Hippophae rhamnoides L. Family: Elaeagnaceae 1

Common Name(s): Sea buckthorn 1


Numerous pharmacological effects are documented in the scientific literature, including antimicrobial, antiulcerogenic, antioxidant, anticancer, radioprotective activity, platelet aggregation, liver injury, cardiovascular risk factors, and effects on skin and mucosa.


Five to 45 g of seed oil and 300 mL/day of juice have been studied in clinical trials.


None well documented.


Avoid use during pregnancy and lactation because clinical trial data are lacking.


Sea buckthorn oil reportedly induces the cytogenetic activity of cyclophosphamide and farmorubicin.

Adverse Reactions

None well documented.


Sea buckthorn has been used as a food in Asia and in Europe. Toxicological studies in animals suggest seed oil and oil from the fruit's soft parts are safe. Acute and chronic toxicity of blood, liver, and heart as well as mutagenicity and teratogenicity of sea buckthorn oils have been studied.


Sea buckthorn is a medium-sized, hardy, deciduous shrub that grows 2 to 6 m in height. It is found along riversides, in mountainous areas, and in sandy and gravel ground at elevations of 3,300 to 4,500 m. The bark is thick and rough. Each leaf is elongate-oblanceolate or elongate-spatulate, green at the top, and silver-ash green on the underside. It flowers in April and the sour, pearl-shaped, yellowish-orange fruits are collected from August to October. There are 9 described subspecies. 1 , 2 , 3 , 4 , 5

The plant is naturally distributed in Central Asia, in Europe from the Black Sea coast to the Alps, and along the shores of northwestern Europe. It also is found in Canada and the United States. 3


Sea buckthorn has a rich history of use in treating numerous medical conditions. It has been called a wonder plant in many Asian countries, including China, India, and Pakistan. The berries have been used for more than 1,000 years in Tibetan and Indian systems of medicine. In traditional Chinese medicine, it has been used to aid digestion and treat cough, circulatory disorders, and pain. 1 , 6 , 7

Because of their hemostatic and anti-inflammatory effects, the fruits are added to prescriptions in Indian and Tibetan medicine to treat pulmonary, GI, cardiac (eg, ischemic heart disease), blood, hepatic, and metabolic disorders. Ancient Tibetan medical literature documents the use of sea buckthorn for fever, inflammation, toxicity, abscesses, cough, colds, clearing sputum, laxative effect, tumors (particularly in the stomach and esophagus), and gynecological diseases. 1 , 2 The flowers are used as a skin softener in Tajikistan. 1 In Mongolia, extracts from the leaves and branches of the plant are used medicinally to treat colitis and enterocolitis in humans and animals. In Middle Asia, the leaves are used to treat GI and skin disorders, and topically applied to treat rheumatoid arthritis. 1 , 2 , 6

In Russia, the oil from the seeds and fruits was used topically to treat chronic dermatoses, eczema, psoriasis, lupus erythematosus, burns, frostbite, and cervical erosion. Oil from the fruit has been used to treat thrombosis. Oil extracts have been used in ophthalmology to treat keratitis, trachoma, conjunctivitis, and injuries or burns of the eyelid. 1

As an economic resource, sea buckthorn is used in a range of products, including oil, juice, cosmetics, shampoos, and as a food additive to candies and jellies. It has been planted extensively to help prevent soil erosion. 8 , 9


Sea buckthorn contains carotenoids, tocopherols, sterols, flavonoids, lipids, ascorbic acid, and tannins.

Flavonols in the leaves, fruit, or juice of sea buckthorn 1 , 10 , 11 , 12 , 13 are noted because of their antioxidant and anticarcinogenic activity. Most occur as C-3 glucosides, rutinosides, and sophorosides.

Flavon-3-ols found in the juice of sea buckthorn include (+) catechin (and +/- gallocatechin) and (-) epicatechin.

Phenolic acids found in the leaves, juice, or fruit of sea buckthorn 1 , 14 include gallic, protecatechuic, p-coumaric, ferulic, p-hydroxybenzoic, and ellagic acid.

Tocopherols and tocotrienols in the fruit or seeds of sea buckthorn, 1 , 8 , 15 collectively known as vitamin E, have antioxidant activity. α-Tocopherol has the highest antioxidant activity and is the most abundant tocopherol, comprising approximately 76% to 89% of the berry.

Carotenoids found in the fruit of sea buckthorn 1 , 16 , 17 , 18 may decrease the risk for age-related macular degeneration and include α-, β-, and γ-carotene; lycopene; zeaxanthin; zeaxanthin dipalmitat; and β-cryptoxanthin palmitate. The antioxidant activity is more potent with extracted sea buckthorn oil because of higher carotenoid levels. Organic acids in the juice of sea buckthorn 1 have been identified as oxalic, citric, tartaric, malic, quinic, and ascorbic acid.

Fatty acid composition differs between the seed oil and soft parts of the fruit. The seed oil contains linoleic, α-linoleic, oleic, palmitic, stearic, and vaccenic acids. The fruit contains palmitoleic, palmitic, and oleic acids. Sterols are found in 1% to 2% of the seed oil and 1% to 3% in the soft parts of the fruit as sitosterol, isofucosterol, campsterol, stigmastanol, citrostadienol, avenasterol, cycloartenol, 24-methylenecycloartanol, and obtusifoliol. 1 , 4 , 19

More than 40 volatile compounds are in the fruit and leaves of sea buckthorn. 1 , 19 , 20 Steam distillation of the fruit yielded 8 aliphatic esters, 9 aliphatic alcohols, and 10 aliphatic hydrocarbons. The primary constituents of the volatile fruit aromas are ethyl dodecenoate, ethyl octanoate, decanol, ethyl decanoate, and ethyl dodecanoate.

The tannins hippophaenins A and B have been isolated from the leaves of sea buckthorn. 21

Uses and Pharmacology

Antimicrobial activity
In vitro data

Phenolic compounds from the berries of sea buckthorn inhibited the growth of gram-negative but not gram-positive bacteria. Myricetin inhibited the growth of lactic acid bacteria from human GI tract flora. Extracts from sea buckthorn seeds inhibited the growth of Bacillus cereus (minimum inhibitory concentration or MIC 200 ppm), Bacillus coagulans (MIC 300 ppm), Bacillus subtilis (MIC 300 ppm), Listeria monocytogenes (MIC 300 ppm), and Yersinia enterocolitica (MIC 350 ppm). 22 , 23 Ethanol extracts of sea buckthorn inhibited the growth of Helicobacter pylori at a MIC around 60 mcg/mL. 24

Antiulcerogenic activity

Compounds active in the protective and curative effects on gastric ulcers may involve the fatty acids, β-carotene, α-tocopherol, and β-sitosterol found in sea buckthorn. Oral administration of CO 2 extracted seed and pulp oils from sea buckthorn may have protective and curative effects in water-immersion ( P < 0.05), reserpine-induced ( P < 0.01), pylorus ligation-induced ( P < 0.05), and acetic acid-induced gastric ulcers ( P < 0.01) in rats. 6 Effects on skin and mucosa have been associated with the sterols and long-chain alcohols in sea buckthorn.

Animal data

The efficacy of a carbopol gel containing an extract of sea buckthorn was examined in experimental skin wounds in rats. Biopsy revealed that epithelization was more intensive, and occurred earlier, and granulation tissue differentiation (mature collagen fibers, profuse vascularity) was quicker in rats treated with the gel extract. 25

Clinical data

One review article documents that topically applied sea buckthorn oil promotes healing of various wounds, burns, and irradiation dermatitis in skin. 4

Dietary supplementation with extracted seed and soft part (berry flesh and peel) sea buckthorn oil was tested on 49 atopic dermatitis patients in a double-blind, parallel, randomized, placebo-controlled trial. Patients took 5 g (10 capsules) of seed oil, pulp oil, or paraffin oil (control group) by mouth daily for 4 months. 26

Patients treated with the seed oil had increased levels of linoleic, α-linolenic, and eicosapentaenoic acids in plasma lipids. After 1 month of treatment, these patients reported improvement of atopic dermatitis symptoms, which correlated with an increase in α-linolenic acid in plasma lipids. The proposed mechanism of action for these positive effects was inhibition of the synthesis of the 4-series leukotrienes from arachidonic acid and an increased synthesis of the 5-series leukotrienes. Patients treated with the pulp oil had increased levels of palmitoleic acid ( P < 0.05) in plasma phospholipids and neutral lipids. However, the changes in palmitoleic acid did not correlate with symptom improvements. The pharmacological effects of the oils may be related to different mechanisms involving components other than fatty acids. No changes were detected in the levels of triacylgylcerols, serum total, and specific IgE. 26

Seed and pulp oil supplementation over 4 months did not lead to changes in the skin glycerophospholipids of 16 atopic dermatitis patients in a placebo-controlled, parallel, randomized, double-blind trial. 27

Effects on liver injury
Animal data

The seed oil inhibited malondialdehyde formation of liver induced by CCl 4 , ethyl alcohol, and acetaminophen in mice. It decreased serum glutamic pyruvic transaminase levels induced by CCl 4 and acetaminophen. Furthermore, the seed oil from sea buckthorn blocked the depletion of glutathione in acetaminophen-induced liver damage. Hepatoprotective properties of the oil have been demonstrated in rats. 28 , 29

Clinical data

Clinical effects of the oil have been tested in 48 cirrhotic patients of Child-Pugh grade A and B treated with a sea buckthorn extract of 15 g by mouth 3 times daily for 6 months. Primary outcomes included measurements of cytokines and various blood parameters of liver fibrosis and liver function tests (eg, IL-6, TNFα, ALB, AST, ALT). Patients treated with sea buckthorn extract had reduced serum levels of laminin, hyaluronic acid, total bile acid, and collagen types III and IV. These results suggest that the seed oil of sea buckthorn may be useful for prevention and treatment of liver disease. 30

Effects on platelet aggregation
In vitro and animal data

Total flavones from sea buckthorn fruit prolonged thrombotic occlusion time in a mouse femoral artery thrombosis model. In the same study, total flavones inhibited platelet aggregation induced by collagen in a concentration-dependent manner but did not affect aggregation induced by arachidonic acid and adenosine diphosphate. Mechanism of action remains unclear but may be caused by suppression of arachidonic acid synthesis by collagen receptor stimulation. 31

Clinical data

The effects of sea buckthorn berry oil on cardiovascular (CV) disease risk was studied over a 4-week period in 12 healthy normolipidemic men in a double-blind, randomized, crossover study. Patients were treated with ten 500 mg capsules of sea buckthorn berry oil by mouth daily. Patients taking sea buckthorn berry oil indicated a clear decrease in the rate of adenosine-5-diphosphate-induced platelet aggregation ( P < 0.05) and maximum aggregation (aggregation percentage at 4 minutes, P < 0.01). The mechanisms behind these effects remain unclear. 32

Effects on CV disease risk factors
Animal data

One review article documents results from animal experiments as to how sea buckthorn oil decreases plasma total and low-density lipoprotein (LDL)-cholesterol levels, increases the level of high-density lipoprotein (HDL)-cholesterol, inhibits thrombus formation and atherosclerosis, and inhibits oxidation of LDL. 4 , 33

Clinical data

The effects on sea buckthorn juice on risk factors for CV disease were studied for 8 weeks in 20 men in a double-blind, placebo-controlled trial. Patients consumed 300 mL sea buckthorn juice or placebo by mouth daily for 8 weeks. Although not statistically significant, sea buckthorn juice supplementation appeared to increase plasma HDL cholesterol and decrease the susceptibility of LDL to oxidation. 33

In a study of 88 patients, total flavones in sea buckthorn did not alter the sympathetic activity in treatment of hypertension when compared with patients being treated with nifedipine and extended-release verapamil. 34

Antioxidant effects
In vitro and animal data

Numerous studies clearly demonstrate the antioxidant activity of sea buckthorn. The alcoholic leaf and fruit extracts of sea buckthorn inhibited chromium (VI)-induced free radicals, apoptosis, and deoxyribonucleic acid fragmentation. A hexane extract inhibited depletion of glutathione in gastric tissue and inhibited nicotine-induced oxidative damage in erythrocytes. Oil supplementation increased the activation of glutathione peroxidase, superoxide dismutase, glucose-6-phosphate dehydrase, and membrane levels of sialic acid and the sulfydryl group in erythrocytes. The oil also protects against oxidative damage from sulfur dioxide. 1 , 4 , 11 , 14 , 22 , 35 , 36

Anticancer and radioprotective effects
In vitro and animal data

Protection against whole-body irradiation has been reported in mice; an alcoholic extract of the berries rendered nearly 82% survival as compared with no survival in untreated irradiated control. In liver, the oil from the berries inhibited the Fenton reaction and radiation-mediated generation of hydroxyl radicals, and superoxide anion mediated nitroblue tetrazolium reduction and FeSO 4 -mediated lipid peroxidation. The radioprotective effects may be associated with any of the following actions: free-radical scavenging, acceleration of stem cell proliferation, immunostimulation, and direct modulation of chromatin organization. 2 , 37 , 38

Flavonoids from oil extracted from the seeds of sea buckthorn induced apoptosis in the liver cancer cell line BEL-7402. In the human breast carcinoma cell line Bcap-37, 32 genes related to apoptosis were induced by flavonoids from seed extracts of sea buckthorn. Flavonols from sea buckthorn inhibited promyelotic leukemia HL-60 cells. Fruit and berry extracts from sea buckthorn inhibited the growth of colon cancer cells HT29 and breast cancer cells MCF-7 in a dose-dependent manner. These extracts inhibited carcinogen-induced forestomach and skin tumorigenesis in mice; mechanisms of action may involve up-regulation of phase II (eg, glutathione S-dimutase, catalase, glutathione peroxidase, glutathione reductase) and antioxidant enzymes. 13 , 39 , 40 , 41 , 42

Sea buckthorn oil may stimulate the recovery of hematopoiesis after chemotherapy. Blood cell counts in mice with myelosuppression fed with oil from sea buckthorn exceeded those in the control group and mortality decreased. 43

Other pharmacological effects

Flavonoids from seed and fruit extracts of sea buckthorn inhibited glycometabolism and reduced serum glucose, serum cholesterol, and serum triglycerides in mice. The seed oil from sea buckthorn may reduce infarction volume after occlusion of middle cerebral artery in rats and protect against ischemic cerebral infarction. Sea buckthorn juice may protect against learning and memory changes caused by lead-induced neurotoxicity in mice. Flavones from sea buckthorn promoted healing of the patellar tendon in a rat model by enhancing collagen deposition and muscle fiber recovery. Administration of a sea buckthorn leaf extract on the same day or 5 days prior to inducing inflammation in the right hind paw of rats reduced the inflammation in a dose-dependent manner when compared with controls. 44 , 45 , 46 , 47 , 48


Doses of seed oil taken orally in clinical trials ranged from 5 to 45 g daily for 4 to 6 months. 26 , 30 , 32 Juice has been administered to volumes of 300 mL daily over 8 weeks. 33


There is no clinical data on safety in pregnancy and lactation.


Cyclophosphamide and farmorubicin

Sea buckthorn oil decreased the cytogenetic action of cyclophosphamide and farmorubicin. 49


Sea buckthorn juice decreased the genotoxic effects of cisplatin on bone marrow and sperm cells in mice at a dose of 1.2 mg/kg. 50

Adverse Reactions

None well documented.


One review article documents sea buckthorn's history of use as a food in Asia and in Europe. Research from toxicological studies using animal models suggests seed oil and oil from the fruit's soft parts are safe. These studies also examined acute and chronic toxicity of blood, liver, and heart as well as mutagenicity and teratogenicity of ingested oils. 4


1. Guliyev VB, Gul M, Yildirim A. Hippophae rhamnoides L.: chromatographic methods to determine chemical composition, use in traditional medicine and pharmacological effects. J Chromatogr B Analyt Technol Biomed Life Sci . 2004;812:291-307.
2. Goel HC, Prasad J, Singh S, Sagar RK, Kumar IP, Sinha AK. Radioprotection by a herbal preparation of Hippophae rhamnoides , RH-3, against whole body lethal irradiation in mice. Phytomedicine . 2002;9:15-25.
3. Yang B, Kallio HP. Fatty acid composition of lipids in sea buckthorn ( Hippophae rhamnoides L.) berries of different origins. J Agric Food Chem . 2001;49;1939-1947.
4. Yang B, Heikki K. Composition and physiological effects of sea buckthorn ( Hippophae ) lipids. Trends Food Sci Technol . 2002;13:160-167.
5. Yang B, Heikki K. Effects of Harvesting Time on Triacylglycerols and Glycerophospholipids of Sea Buckthorn ( Hippophae rhamnoides L.) Berries of Different Origins. J Food Compost Anal . 2002;15:143-157.
6. Xing J, Yang B, Dong Y, Wang B, Wang J, Kallio HP. Effects of sea buckthorn ( Hippophae rhamnoides L.) seed and pulp oils on experimental models of gastric ulcer in rats. Fitoterapia . 2002;73:644-650.
7. Yang B, Karlsson RM, Oksman PH, Kallio HP. Phytosterols in sea buckthorn ( Hippophae rhamnoides L.) berries: identification and effects of different origins and harvesting times. J Agric Food Chem . 2001;49:5620-5629.
8. Kallio H, Yang B, Peippo P, Tahvonen R, Pan R. Triacylglycerols, glycerophospholipids, tocopherols, and tocotrienols in berries and seeds of two subspecies (ssp. sinensis and mongolica) of Sea Buckthorn ( Hippophaae rhamnoides ). J Agric Food Chem . 2002;50:3004-3009.
9. Beveridge T, Li TS, Oomah BD, Smith A. Sea buckthorn products: manufacture and composition. J Agric Food Chem . 1999;47:3480-3488.
10. Hakkinen SH, Karenlampi SO, Heinonen IM, Mykkanen HM, Torronen AR. Content of the flavonols quercetin, myricetin, and kaempferol in 25 edible berries. J Agric Food Chem . 1999;47:2274-2279.
11. Rosch D, Mugge C, Fogliano V, Kroh LW. Antioxidant oligomeric proanthocyanidins from sea buckthorn ( Hippophae rhamnoides ) Pomace. J Agric Food Chem . 2004;52:6712-6718.
12. Rosch D, Krumbein A, Mugge C, Kroh LW. Structural investigations of flavonol glycosides from sea buckthorn ( Hippophae rhamnoides ) pomace by NMR spectroscopy and HPLC-ESI-MS(n). J Agric Food Chem . 2004;52:4039-4046.
13. Hibasami H, Mitani A, Katsuzaki H, Imai K, Yoshioka K, Komiya T. Isolation of five types of flavonol from seabuckthorn ( Hippophae rhamnoides ) and induction of apoptosis by some of the flavonols in human promyelotic leukemia HL-60 cells. Int J Mol Med . 2005;15:805-809.
14. Rosch D, Bergmann M, Knorr D, Kroh L. Structure-antioxidant efficiency relationships of phenolic compounds and their contribution to the antioxidant activity of sea buckthorn juice. J Agric Food Chem . 2003;51:4233-4239.
15. Luhua Z, Ying T, Zhengyu Z, Guangji W. Determination of alpha-tocopherol in the Traditional Chinese Medicinal preparation Sea buckthorn oil capsule by non-aqueous reversed phase-HPLC. Chem Pharm Bull (Tokyo) . 2004;52:150-152.
16. Weller P, Breithaupt DE. Identification and quantification of zeaxanthin esters in plants using liquid chromatography-mass spectrometry. J Agric Food Chem . 2003;51:7044-7049.
17. Kasparaviciene G, Briedis V, Ivanauskas L. Influence of sea buckthorn oil production technology on its antioxidant activity [in Lithuanian]. Medicina (Kaunas) . 2004;40:753-757.
18. Pintea A, Varga A, Stepnowski P, Socaciu C, Culea M, Diehl HA. Chromatographic analysis of carotenol fatty acid esters in Physalis alkekengi and Hippophae rhamnoides . Phytochem Anal . 2005;16:188-195.
19. Cakir A. Essential oil and fatty acid composition of the fruits of Hippophae rhamnoides L. (Sea Buckthorn) and Myrtus communis L. from Turkey. Biochem Syst Ecol . 2004;32:809-816.
20. Tian C, Nan P, Chen J, Zhong Y. Volatile composition of Chinese Hippophae rhamnoides and its chemotaxonomic implications. Biochem Syst Ecol . 2004;32:431-441.
21. Yoshida T, Tanaka K, Chen X, Okuda T. Tannins from Hippophae rhamnoides . Phytochemistry . 1991;30:663-666.
22. Negi P, Chauhan A, Sadia G, Rohinishree Y, Ramteke R. Antioxidant and antibacterial activities of various seabuckthorn ( Hippophae rhamnoides L.) seed extracts. Food Chem . 2005;92:119-124.
23. Puupponen-Pimia R, Nohynek L, Meier C, et al. Antimicrobial properties of phenolic compounds from berries. J Appl Microbiol . 2001;90:494-507.
24. Li Y, Xu C, Zhang Q, Liu JY, Tan RX. In vitro anti- Helicobacter pylori action of 30 Chinese herbal medicines used to treat ulcer diseases. J Ethnopharmacol . 2005;98:329-333.
25. Ianev E, Radev S, Balutsov M, Klouchek E, Popov A. The effect of an extract of sea buckthorn ( Hippophae rhamnoides L.) on the healing of experimental skin wounds in rats [in Bulgarian]. Khirurgiia (Sofiia) . 1995;48:30-33.
26. Yang B, Kalimo KO, Mattila LM, et al. Effects of dietary supplementation with sea buckthorn ( Hippophae rhamnoides ) seed and pulp oils on atopic dermatitis. J Nutr Biochem . 1999;10:622-630.
27. Yang B, Kalimo KO, Tahvonen RL, Mattila LM, Katajisto JK, Kallio HP. Effect of dietary supplementation with sea buckthorn ( Hippophae rhamnoides ) seed and pulp oils on the fatty acid composition of skin glycerophospholipids of patients with atopic dermatitis. J Nutr Biochem . 2000;11:338-340.
28. Cheng T, Li T, Duan Z, Cao Z, Ma Z, Zhang P. Acute toxicity of flesh oil of Hippophae rhamnoides L. and its protection against experimental hepatic injury [in Chinese]. Zhongguo Zhong Yao Za Zhi . 1990;15:45-47,64.
29. Lipkan GM, Oliinyk OA. Hepatoprotective effect of the sea buckthorn-and-pinks oil [in Ukrainian]. Lik Sprava . 2000 Sep;96-99.
30. Gao ZL, Gu XH, Cheng FT, Jiang FH. Effect of sea buckthorn on liver fibrosis: a clinical study. World J Gastroenterol . 2003;9:1615-1617.
31. Cheng J, Kondo K, Suzuki Y, Ikeda Y, Meng X, Umemura K. Inhibitory effects of total flavones of Hippophae Rhamnoides L on thrombosis in mouse femoral artery and in vitro platelet aggregation. Life Sci . 2003;72:2263-2271.
32. Johansson AK, Korte H, Yang B, Stanley JC, Kallio HP. Sea buckthorn berry oil inhibits platelet aggregation. J Nutr Biochem . 2000;11:491-495.
33. Eccleston C, Baoru Y, Tahvonen R, Kallio H, Rimbach GH, Minihane AM. Effects of an antioxidant-rich juice (sea buckthorn) on risk factors for coronary heart disease in humans. J Nutr Biochem . 2002;13:346-354.
34. Zhang X, Zhang M, Gao Z, Wang J, Wang Z. Effect of total flavones of Hippophae rhamnoides L. on sympathetic activity in hypertension [in Chinese]. Hua Xi Yi Ke Da Xue Xue Bao . 2001;32:547-550.
35. Geetha S, Sai Ram M, Mongia SS, Singh V, Ilavazhagan G, Sawhney RC. Evaluation of antioxidant activity of leaf extract of Seabuckthorn ( Hippophae rhamnoides L.) on chromium(VI) induced oxidative stress in albino rats. J Ethnopharmacol . 2003;87:247-251.
36. Wu D, Meng Z. Effect of sulfur dioxide inhalation on the glutathione redox system in mice and protective role of sea buckthorn seed oil. Arch Environ Contam Toxicol . 2003;45:423-428.
37. Kumar IP, Namita S, Goel HC. Modulation of chromatin organization by RH-3, a preparation of Hippophae rhamnoides , a possible role in radioprotection. Mol Cell Biochem . 2002;238:1-9.
38. Agrawala PK, Goel HC. Protective effect of RH-3 with special reference to radiation induced micronuclei in mouse bone marrow. Indian J Exp Biol . 2002;40:525-530.
39. Sun B, Zhang P, Qu W, Zhang X, Zhuang X, Yang H. Study on effect of flavonoids from oil-removed seeds of Hippophae rhamnoides on inducing apoptosis of human hepatoma cell [in Chinese]. Zhong Yao Cai . 2003;26:875-877.
40. Olsson ME, Gustavsson KE, Andersson S, Nilsson A, Duan RD. Inhibition of cancer cell proliferation in vitro by fruit and berry extracts and correlations with antioxidant levels. J Agric Food Chem . 2004;52:7264-7271.
41. Padmavathi B, Upreti M, Singh V, Rao AR, Singh RP, Rath PC. Chemoprevention by Hippophae rhamnoides : effects on tumorigenesis, phase II and antioxidant enzymes, and IRF-1 transcription factor. Nutr Cancer . 2005;51:59-67.
42. Zhang P, Mao YC, Sun B, Qian M, Qu WJ. Changes in apoptosis-related genes expression profile in human breast carcinoma cell line Bcap-37 induced by flavonoids from seed residues of Hippophae Rhamnoides L [in Chinese]. Ai Zheng . 2005;24:454-460.
43. Chen Y, Zhong X, Liu T, Ge Z. The study on the effects of the oil from Hippophae rhamnoides in hematopoiesis [in Chinese]. Zhong Yao Cai . 2003;26:572-575.
44. Cao Q, Qu W, Deng Y, Zhang Z, Niu W, Pan Y. Effect of flavonoids from the seed and fruit residue of Hippophae rhamnoides L. on glycometabolism in mice [in Chinese]. Zhong Yao Cai . 2003;26:735-737.
45. Cheng TJ, Wang YB, Gao LP, Sun YF, Zhang J. The protection of seed oil of Hippophae rharmnoides on ischemic cerebral infarction in rats [in Chinese]. Zhongguo Zhong Yao Za Zhi . 2003;28:548-550.
46. Xu Y, Li G, Han C, Sun L, Zhao R, Cui S. Protective effects of Hippophae rhamnoides L. juice on lead-induced neurotoxicity in mice. Biol Pharm Bull . 2005;28:490-494.
47. Fu SC, Hui CW, Li LC, et al. Total flavones of Hippophae rhamnoides promotes early restoration of ultimate stress of healing patellar tendon in a rat model. Med Eng Phys . 2005;27:313-321.
48. Ganju L, Padwad Y, Singh R, et al. Anti-inflammatory activity of Seabuckthorn ( Hippophae rhamnoides ) leaves. Int Immunopharmacol . 2005;5:1675-1684.
49. Nersesian AK, Zil'fian VN, Kumkumadzhian VA, Proshian NV. Antimutagenic properties of sea buckthorn oil [in Russian]. Genetika . 1990;26:378-380.
50. Nersesyan A, Muradyan R. Sea-buckthorn juice protects mice against genotoxic action of cisplatin. Exp Oncol . 2004;26:153-155.

Copyright © 2009 Wolters Kluwer Health