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Generic Name: memantine (meh MAN teen)
Brand Names: Namenda, Namenda XR

What is Namenda?

Namenda (memantine) reduces the actions of chemicals in the brain that may contribute to the symptoms of Alzheimer's disease.

Namenda is used to treat moderate to severe dementia of the Alzheimer's type.

Namenda may also be used for purposes not listed in this medication guide.

Important information

Before using Namenda, tell your doctor if you are allergic to any drugs, or if you have a seizure disorder, cataracts, liver or kidney disease, or a bladder or kidney infection.

Slideshow: Flashback: FDA Drug Approvals 2013

Namenda can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Before taking this medicine

You should not use Namenda if you are allergic to memantine.

To make sure Namenda is safe for you, tell your doctor if you have:

  • epilepsy or other seizure disorder;

  • liver disease;

  • kidney disease;

  • urination problems; or

  • a bladder or kidney infection.

Namenda is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether memantine passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How should I take Namenda?

Take Namenda exactly as it was prescribed for you. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Namenda can be taken with or without food.

Do not crush, chew, break, or open an extended-release capsule. Swallow it whole.

To make swallowing easier, you may open the extended-release capsule and sprinkle the medicine into a spoonful of applesauce. Swallow right away without chewing. Do not save the mixture for later use.

Measure liquid medicine (oral solution) with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

Do not mix the oral solution with any other liquids.

Rinse the empty oral syringe with clean water and allow it to air dry after every use.

Use Namenda regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

Your doctor will need to check your progress while you are using Namenda.

Store Namenda at room temperature away from moisture and heat. Keep the liquid medicine bottle tightly closed with the cap provided. Do not store the bottle with the oral syringe in it.

Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.

Namenda dosing information

Usual Adult Dose for Alzheimer's Disease:

IMMEDIATE-RELEASE:
Initial dose: 5 mg orally once a day, then titrated upwards by 5 mg per week
Maintenance dose: 5 mg once a day up to 10 mg twice a day
Maximum dose: 20 mg per day

EXTENDED-RELEASE:
Initial dose: 7 mg orally once a day, then titrated upwards by 7 mg per week
Maintenance dose: 7 mg once a day up to 28 mg once a day
Maximum dose: 28 mg orally once a day

Approved indication: For use in the treatment of moderate to severe dementia of the Alzheimer's type.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

If you miss doses or forget to take your medicine for several days, call your doctor before starting the medicine again.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Namenda?

Namenda can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Namenda side effects

Get emergency medical help if you have signs of an allergic reaction to Namenda: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • severe headache, blurred vision, pounding in your neck or ears;

  • seizure (convulsions); or

  • unusual changes in mood or behavior.

Common Namenda side effects may include:

  • diarrhea;

  • dizziness; or

  • headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Namenda?

Tell your doctor about all your current medicines and any you start or stop using, especially:

  • amantadine;

  • zonisamide;

  • cough medicine that contains dextromethorphan (Delsym, Robitussin Maximum Strength, Vicks 44, and others);

  • medicines to make the urine alkaline - urine sodium bicarbonate, potassium citrate (K-Lyte, Urocit-K), sodium citrate and citric acid (Bicitra, Oracit), or sodium citrate and potassium (Citrolith, Polycitra); or

  • medicine to treat glaucoma or increased pressure inside the eyes - acetazolamide, methazolamide.

This list is not complete. Other drugs may interact with memantine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

  • Your pharmacist can provide more information about Namenda.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Namenda only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2015 Cerner Multum, Inc. Version: 3.01. Revision Date: 2015-02-11, 8:43:16 AM.

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