Generic name: memantine hydrochloride
Dosage form: tablet, oral solution
This dosage information does not include all the information needed to use Namenda safely and effectively. See full prescribing information for Namenda.
The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.
The dosage of Namenda (memantine hydrochloride) shown to be effective in controlled clinical trials is 20 mg/day.
The recommended starting dose of Namenda is 5 mg once daily. The recommended target dose is 20 mg/day. The dose should be increased in 5 mg increments to 10 mg/day (5 mg twice a day), 15 mg/day (5 mg and 10 mg as separate doses), and 20 mg/day (10 mg twice a day). The minimum recommended interval between dose increases is one week.
Namenda can be taken with or without food.
Patients/caregivers should be instructed on how to use the Namenda Oral Solution dosing device. They should be made aware of the patient instruction sheet that is enclosed with the product. Patients/caregivers should be instructed to address any questions on the usage of the solution to their physician or pharmacist.
Doses in Special Populations
A target dose of 5 mg BID is recommended in patients with severe renal impairment (creatinine clearance of 5 – 29 mL/min based on the Cockroft-Gault equation):
For males: CLcr = [140-age (years)] · Weight (kg)/[72 · serum creatinine (mg/dL)]
For females: CLcr = 0.85 · [140-age (years)] · Weight (kg)/[72 · serum creatinine (mg/dL)]