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hydrochlorothiazide and fosinopril

Generic Name: hydrochlorothiazide and fosinopril (HYE droe KLOR oh THY a zide and foe SIN oh pril)
Brand Name: Monopril HCT

What is fosinopril and hydrochlorothiazide?

Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

Fosinopril is in a group of drugs called ACE inhibitors. ACE stands for angiotensin converting enzyme. Fosinopril lowers blood pressure and also relieves symptoms of fluid retention.

Hydrochlorothiazide and fosinopril is a combination medicine used to treat hypertension (high blood pressure).

Hydrochlorothiazide and fosinopril may also be used for purposes not listed in this medication guide.

What is the most important information I should know about fosinopril and hydrochlorothiazide?

If you have diabetes, do not use hydrochlorothiazide and fosinopril together with any medication that contains aliskiren (Amturnide, Tekturna, Tekamlo, Valturna).

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Do not use if you are pregnant. Stop using and tell your doctor right away if you become pregnant.

What should I discuss with my healthcare provider before taking fosinopril and hydrochlorothiazide?

You should not use this medication if you are allergic to hydrochlorothiazide or fosinopril, or if:

  • you are unable to urinate; or

  • you are allergic to any other ACE inhibitor, such as benazepril, captopril, enalapril, lisinopril, quinapril, ramipril, trandolapril, and others.

If you have diabetes, do not use hydrochlorothiazide and fosinopril together with any medication that contains aliskiren (Amturnide, Tekturna, Tekamlo, Valturna).

You may also need to avoid taking hydrochlorothiazide and fosinopril with aliskiren if you have kidney disease.

To make sure hydrochlorothiazide and fosinopril is safe for you, tell your doctor if you have:

  • kidney disease (or if you are on dialysis);

  • liver disease;

  • congestive heart failure;

  • gout;

  • lupus;

  • diabetes; or

  • an allergy to sulfa drugs or penicillin.

FDA pregnancy category D. Do not use if you are pregnant. Stop using and tell your doctor right away if you become pregnant. Hydrochlorothiazide and fosinopril can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. Use effective birth control.

Hydrochlorothiazide and fosinopril can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.

How should I take fosinopril and hydrochlorothiazide?

Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Conditions that may cause very low blood pressure include: vomiting, diarrhea, heavy sweating, heart disease, dialysis, a low-salt diet, or taking diuretics (water pills). Follow your doctor's instructions about the type and amount of liquids you should drink while taking hydrochlorothiazide and fosinopril. Tell your doctor if you have a prolonged illness that causes diarrhea or vomiting.

Your blood pressure will need to be checked often. Your blood and urine may also be tested if you have been vomiting or are dehydrated. Visit your doctor regularly.

Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.

If you need surgery, tell the surgeon ahead of time that you are using hydrochlorothiazide and fosinopril. You may need to stop using the medicine for a short time.

Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking fosinopril and hydrochlorothiazide?

Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Drinking alcohol can further lower your blood pressure and may increase certain side effects of hydrochlorothiazide and fosinopril.

Do not use potassium supplements or salt substitutes while you are taking hydrochlorothiazide and fosinopril, unless your doctor has told you to.

Fosinopril and hydrochlorothiazide side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;

  • pale skin, easy bruising or bleeding;

  • fever, swollen gums, painful mouth sores, pain when swallowing, cold or flu symptoms;

  • high potassium--slow heart rate, weak pulse, muscle weakness, tingly feeling;

  • low potassium--confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling;

  • low levels of sodium--headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady; or

  • severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Common side effects may include:

  • headache, dizziness;

  • cough; or

  • tired feeling.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

Hydrochlorothiazide and fosinopril dosing information

Usual Adult Dose for Hypertension:

Initial dose: 1 tablet (10 mg-12.5 mg) orally once a day.
Maintenance dose: Up to 20 mg-12.5 mg orally once a day.

What other drugs will affect fosinopril and hydrochlorothiazide?

Other drugs may interact with hydrochlorothiazide and fosinopril, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Where can I get more information?

  • Your pharmacist can provide more information about hydrochlorothiazide and fosinopril.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 5.01. Revision Date: 2013-11-26, 11:33:41 AM.

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