Fosinopril/Hydrochlorothiazide Dosage
This dosage information may not include all the information needed to use Fosinopril/Hydrochlorothiazide safely and effectively. See additional information for Fosinopril/Hydrochlorothiazide.
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Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Hypertension
Initial dose: 1 tablet (10 mg-12.5 mg) orally once a day.
Maintenance dose: Up to 20 mg-12.5 mg orally once a day.
Renal Dose Adjustments
The usual regimens of therapy with fosinopril-hydrochlorothiazide need not be adjusted as long as the patient's creatinine clearance is 30 mL/min or greater. In patients with more severe renal impairment, loop diuretics are preferred to thiazides, so fosinopril-hydrochlorothiazide is not recommended.
Liver Dose Adjustments
Thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease, since minor alterations of fluid and electrolyte balance may precipitate hepatic coma.
Precautions
Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).
Dialysis
Fosinopril is not well dialyzed. Clearance by hemodialysis and peritoneal dialysis averages 2% and 7%, respectively.
