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Generic Name: iloperidone (EYE loe PER i done)
Brand Name: Fanapt

What is iloperidone?

Iloperidone is an antipsychotic medication. It works by changing the effects of chemicals in the brain.

Iloperidone is used to treat schizophrenia.

Iloperidone may also be used for purposes not listed in this medication guide.

What is the most important information I should know about iloperidone?

Iloperidone is not approved for use in psychotic conditions related to dementia. Iloperidone may increase the risk of death in older adults with dementia-related conditions.

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What should I discuss with my healthcare provider before taking iloperidone?

You should not use iloperidone if you are allergic to it.

Iloperidone is not for use in psychotic conditions related to dementia. Iloperidone may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions.

To make sure iloperidone is safe for you, tell your doctor if you have:

  • heart disease or high blood pressure;

  • a personal or family history of Long QT syndrome;

  • a history of heart attack or stroke (including "mini-stroke");

  • seizures or epilepsy;

  • diabetes (iloperidone may raise your blood sugar);

  • kidney or liver disease;

  • a history of breast cancer;

  • high cholesterol or triglycerides;

  • a history of low white blood cell (WBC) counts;

  • an electrolyte imbalance (such as low levels of potassium or magnesium in your blood);

  • diabetes, or risk factors such as being overweight or having a family history of diabetes;

  • a history of suicidal thoughts;

  • trouble swallowing; or

  • if you are malnourished or dehydrated.

FDA pregnancy category C. It is not known whether iloperidone will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.

Taking antipsychotic medication during the last 3 months of pregnancy may cause problems in the newborn, such as withdrawal symptoms, breathing problems, feeding problems, fussiness, tremors, and limp or stiff muscles. However, you may have withdrawal symptoms or other problems if you stop taking your medicine during pregnancy. If you become pregnant while taking iloperidone, do not stop taking it without your doctor's advice.

It is not known whether iloperidone passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are taking iloperidone.

How should I take iloperidone?

Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Iloperidone can be taken with or without food.

Your doctor will need to check your progress while you are using iloperidone.

If you have stopped taking iloperidone for more than 3 days in a row, talk with your doctor before you start taking it again. You may need to restart the medicine at a lower dose.

Store at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking iloperidone?

While you are taking iloperidone, you may be more sensitive to temperature extremes such as very hot or cold conditions. Avoid getting too cold, or becoming overheated or dehydrated. Drink plenty of fluids, especially in hot weather and during exercise. It is easier to become dangerously overheated and dehydrated while you are taking iloperidone.

Iloperidone may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Drinking alcohol can increase certain side effects of iloperidone.

Iloperidone side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats;

  • uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement);

  • sudden weakness or ill feeling, fever, chills, sore throat, swollen gums, painful mouth sores, pain when swallowing, skin sores, cold or flu symptoms, cough;

  • little or no urinating;

  • penis erection that is painful or lasts 4 hours or longer; or

  • severe nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out.

Older adults may be more likely to have side effects from this medicine.

Common side effects may include:

  • weight gain;

  • dizziness, drowsiness, tired feeling;

  • dry mouth, stuffy nose; or

  • fast heart rate.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect iloperidone?

Taking this medicine with other drugs that make you sleepy can worsen this effect. Ask your doctor before taking iloperidone with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.

Tell your doctor about all medicines you use, and those you start or stop using during your treatment with iloperidone, especially:

  • droperidol;

  • methadone;

  • an antibiotic--azithromycin, ciprofloxacin, clarithromycin, erythromycin, levofloxacin, moxifloxacin, norfloxacin, ofloxacin, pentamidine;

  • antifungal medicine--fluconazole, ketoconazole, posaconazole, voriconazole;

  • cancer medicine--arsenic trioxide, vandetanib, vemurafenib;

  • an antidepressant--amitriptylline, amoxapine, citalopram, clomipramine, desipramine, escitalopram, fluoxetine, imipramine;

  • anti-malaria medication--chloroquine, lumefantrine;

  • heart rhythm medicine--amiodarone, disopyramide, dofetilide, dronedarone, flecainide, ibutilide, procainamide, quinidine, sotalol; or

  • medicine to treat a psychiatric disorder--chlorpromazine, haloperidol, paliperidone, pimozide, ziprasidone, others.

This list is not complete. Other drugs may interact with iloperidone, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

  • Your pharmacist can provide more information about iloperidone.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 9.01. Revision Date: 2014-06-26, 1:08:42 PM.

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