Istalol

Generic Name: timolol ophthalmic (TIM oh lol off THAL mik)
Brand Names: Betimol, Istalol, Timoptic Ocudose, Timoptic Ocumeter, Timoptic Ocumeter Plus, Timoptic-XE

What is Istalol?

Istalol ophthalmic (for the eyes) is a beta-blocker that also reduces pressure inside the eye.

Istalol is used to treat open-angle glaucoma and other causes of high pressure inside the eye.

Istalol may also be used for other purposes not listed in this medication guide.

Important information

Do not allow the dropper to touch any surface, including the eyes or hands. If the dropper becomes contaminated it could cause an infection in your eye, which can lead to vision loss or serious damage to the eye.

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Do not use any other eye medication unless your doctor has prescribed it for you. If you use another eye medication, use it at least 10 minutes before or after using Istalol. Do not use the medications at the same time.

Istalol can cause blurred vision. Be careful if you drive or do anything that requires you to be able to see clearly.

Before using Istalol

Do not use Istalol if you are allergic to timolol, or if you have:

  • asthma or severe chronic obstructive pulmonary disease (COPD);

  • certain serious heart conditions, especially "AV block"; or

  • severe or uncontrolled congestive heart failure.

If you have any of these other conditions, you may need a dose adjustment or special tests to safely use Istalol:

  • breathing problems such as bronchitis or emphysema;

  • a history of heart disease or congestive heart failure;

  • diabetes;

  • history of stroke, blood clot, or circulation problems;

  • a thyroid disorder;

  • a muscle disorder such as myasthenia gravis;

  • kidney disease; or

  • liver disease.

FDA pregnancy category C. Istalol may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Istalol passes into breast milk and could cause harm to a nursing baby. Do not use Istalol without telling your doctor if you are breast-feeding a baby. Do not use this medicine for a child younger than 2 years old.

See also: Pregnancy and breastfeeding warnings (in more detail)

How should I use Istalol?

Use Istalol exactly as it was prescribed for you. Do not use the medication in larger amounts, or use it for longer than recommended by your doctor. Follow the instructions on your prescription label.

Wash your hands before using Istalol eye drops. Do not use Istalol while you are wearing contact lenses. Istalol may contain a preservative that can be absorbed by soft contact lenses. Wait at least 15 minutes after using Istalol before putting your contact lenses in.

To apply the eye drops:

  • Tilt your head back slightly and pull down your lower eyelid. Hold the dropper above the eye with the dropper tip down. Look up and away from the dropper as you squeeze out a drop, then close your eye.

  • Gently press your finger to the inside corner of the eye (near your nose) for about 1 minute to keep the liquid from draining into your tear duct. If you use more than one drop in the same eye, wait about 5 minutes before putting in the next drop.

  • Do not allow the dropper tip to touch any surface, including the eyes or hands. If the dropper becomes contaminated it could cause an infection in your eye, which can lead to vision loss or serious damage to the eye.

Do not use Istalol eye drops if the liquid has changed colors or has particles in it. Call your doctor for a new prescription.

If you need to have any type of surgery, especially eye surgery, tell the surgeon ahead of time that you are using Istalol. You may need to stop using the medicine for a short time.

Store Istalol at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

What happens if I miss a dose?

Use the medication as soon as you remember. If it is almost time for the next dose, skip the missed dose and use the medicine at the next regularly scheduled time. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include feeling dizzy or short of breath, headache, slow heart beat, chest pain, or fainting.

What should I avoid?

Istalol can cause blurred vision. Be careful if you drive or do anything that requires you to be able to see clearly.

Do not use any other eye medication unless your doctor has prescribed it for you. If you use another eye medication, use it at least 10 minutes before or after using Istalol. Do not use the medications at the same time.

Istalol side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using Istalol and call your doctor at once if you have any of these serious side effects:

  • swelling or redness of your eyelids;

  • eye redness, discomfort, or sensitivity to light;

  • drainage, crusting, or oozing of your eyes or eyelids;

  • depressed mood, confusion, hallucinations, unusual thoughts or behavior;

  • wheezing, gasping, or other breathing problems;

  • swelling, rapid weight gain;

  • chest pain, slow or uneven heart rate; or

  • feeling short of breath, even with mild exertion.

Less serious side effects may include:

  • blurred vision, double vision, drooping eyelid;

  • burning or stinging in your eye;

  • headache, weakness, drowsiness;

  • numbness, tingling, or cold feeling in your hands or feet;

  • ringing in your ears;

  • dry mouth;

  • nausea, diarrhea, loss of appetite, upset stomach;

  • skin rash or worsening psoriasis;

  • sleep problems (insomnia); or

  • cough, stuffy nose.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Istalol?

Before using Istalol, tell your doctor if you are using any of the following drugs:

  • clonidine (Catapres);

  • quinidine (Cardioquin, Quinadex, Quinaglute);

  • reserpine;

  • digitalis (digoxin, Lanoxin, Lanoxicaps);

  • acetazolamide (Diamox), dichlorphenamide (Daranide), or methazolamide (Neptazane);

  • oral timolol (Blocadren);

  • any other beta-blocker such as atenolol (Tenormin), bisoprolol (Zebeta), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol), nadolol (Corgard), penbutolol (Levatol), pindolol (Visken), propranolol (Inderal, InnoPran), sotalol (Betapace), and others;

  • a calcium channel blocker such as diltiazem (Tiazac, Cartia, Cardizem), felodipine (Plendil), nifedipine (Procardia, Adalat), verapamil (Calan, Covera, Isoptin, Verelan), and others; or

  • antidepressants such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil), or sertraline (Zoloft).

This list is not complete and there may be other drugs that can interact with Istalol. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

  • Your pharmacist can provide more information about Istalol.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Istalol only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2014 Cerner Multum, Inc. Version: 7.01. Revision Date: 04/28/2009 3:28:38 PM.

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