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Tadalafil and Alcohol / Food Interactions

Drug Interactions (283) Alcohol/Food Interactions (2)

There are 2 alcohol/food/lifestyle interactions with tadalafil which include:

Tadalafil and Alcohol (Ethanol)

Moderate Drug Interaction

GENERALLY AVOID: Alcohol may potentiate the hypotensive effects of phosphodiesterase-5 (PDE5) inhibitors, and vice versa, as both are mild systemic vasodilators. In clinical pharmacology studies using tadalafil, more subjects administered alcohol at a dose of 0.7 g/kg (consumed within 10 minutes; equivalent to approximately 6 ounces of 80-proof vodka in an 80-kg male) in combination with tadalafil 10 or 20 mg single doses had clinically significant decreases in blood pressure than with alcohol alone. There were reports of postural dizziness, and orthostatic hypotension was observed in some. When tadalafil 20 mg was administered with alcohol at a lower dose of 0.6 g/kg (equivalent to approximately 4 ounces of 80-proof vodka), orthostatic hypotension was not observed, dizziness occurred with similar frequency relative to alcohol alone, and the hypotensive effects of alcohol were not potentiated. Neither tadalafil nor alcohol affected the plasma concentrations of the other. Sildenafil 50 mg and vardenafil 20 mg reportedly did not potentiate the hypotensive effect of alcohol in healthy volunteers with mean maximum blood alcohol levels of 0.08% and in healthy volunteers administered alcohol at a dose of 0.5 g/kg, respectively.

MANAGEMENT: Based on known pharmacology of the drugs, patients taking PDE5 inhibitors should probably avoid consuming large amounts of alcohol, which may increase the potential for orthostatic signs and symptoms, including increase in heart rate, decrease in standing blood pressure, dizziness, and headache.

Moderate Food Interaction

 

GENERALLY AVOID: Alcohol may potentiate the hypotensive effects of tadalafil, and vice versa, as both are mild systemic vasodilators. In clinical pharmacology studies, more subjects administered alcohol at a dose of 0.7 g/kg (consumed within 10 minutes; equivalent to approximately 6 ounces of 80-proof vodka in an 80-kg male) in combination with tadalafil 10 or 20 mg single doses had clinically significant decreases in blood pressure than with alcohol alone. There were reports of postural dizziness, and orthostatic hypotension was observed in some. When tadalafil 20 mg was administered with alcohol at a lower dose of 0.6 g/kg (equivalent to approximately 4 ounces of 80-proof vodka), orthostatic hypotension was not observed, dizziness occurred with similar frequency relative to alcohol alone, and the hypotensive effects of alcohol were not potentiated. Neither tadalafil nor alcohol affected the plasma concentrations of the other.

GENERALLY AVOID: Coadministration with grapefruit juice is likely to increase the plasma concentrations of tadalafil, which is primarily metabolized by CYP450 3A4. However, the interaction has not been studied. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruit.

MANAGEMENT: Patients taking tadalafil should probably avoid consuming large amounts of alcohol, which may increase the potential for orthostatic signs and symptoms, including increase in heart rate, decrease in standing blood pressure, dizziness, and headache. It may also be appropriate to avoid consuming large amounts of grapefruit juice.

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tadalafil drug Interactions

There are 283 drug interactions with tadalafil

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Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.

Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.

Do not stop taking any medications without consulting your healthcare provider.


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