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Drug Interactions between Nilandron and Sanctura

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

No interactions were found between Nilandron and Sanctura. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Nilandron

A total of 257 drugs are known to interact with Nilandron.

Sanctura

A total of 215 drugs are known to interact with Sanctura.

Drug and food interactions

Moderate

nilutamide food

Applies to: Nilandron (nilutamide)

GENERALLY AVOID: Alcohol intolerance has been reported in 5% to 20% of patients following administration of nilutamide in clinical studies. Symptoms include facial flushes, malaise, and hypotension.

MANAGEMENT: Consumption of alcoholic beverages should be avoided in patients who experience alcohol intolerance with nilutamide.

References

  1. (2001) "Product Information. Nilandron (nilutamide)." Hoechst Marion Roussel
  2. Decensi A, Guarneri D, Paoletti MC, Lalanne JM, Merlo F, Boccardo F (1991) "Phase II study of the pure non-steroidal antiandrogen nilutamide in prostatic cancer. Italian Prostatic Cancer Project (PONCAP)." Eur J Cancer, 27, p. 1100-4

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Moderate

trospium food

Applies to: Sanctura (trospium)

ADJUST DOSING INTERVAL: Food may reduce the oral absorption and bioavailability of trospium chloride. According to the product labeling, administration of trospium chloride with a high fat meal reduced the peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) by 70% to 80% compared to administration while fasting.

MANAGEMENT: To ensure maximal oral absorption, trospium chloride should be administered at least 1 hour before meals or on an empty stomach.

References

  1. "Product Information. Sanctura (trospium)." Odyssey Pharmaceuticals
  2. Cerner Multum, Inc. "UK Summary of Product Characteristics."
  3. Canadian Pharmacists Association (2006) e-CPS. http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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