Methotrexate Drug Interactions
Currently displaying 139 drugs known to have a major interaction with methotrexate.
- 139 major drug interactions
- 539 moderate drug interactions
- 16 minor drug interactions
Major interactions with methotrexate
Note: Showing generic names only.
A
- abrocitinib
- acitretin
- adalimumab
- adefovir
- alemtuzumab
- allogeneic processed thymus tissue
- aminolevulinic acid
- amoxicillin
- ampicillin
- aspirin
B
C
- carbenicillin
- certolizumab
- chikungunya vaccine, live (cvx 317)
- chloramphenicol
- cholera vaccine, live
- choline salicylate
- cidofovir
- cladribine
- cloxacillin
- clozapine
- cytomegalovirus immune globulin
D
- deferasirox
- deferiprone
- dengue vaccine
- deucravacitinib
- dexlansoprazole
- diatrizoate
- diclofenac
- dicloxacillin
- diflunisal
E
F
G
I
- ibuprofen
- immune globulin intravenous
- immune globulin intravenous and subcutaneous
- indomethacin
- infliximab
- influenza virus vaccine, h1n1, live
- influenza virus vaccine, live
- inotersen
- iodamide
- iodipamide
- iodixanol
- iohexol
- iomeprol
- iopamidol
- iopromide
- iothalamate
- ioversol
- ioxaglate
- ioxilan
K
L
M
- magnesium salicylate
- measles virus vaccine
- meclofenamate
- mefenamic acid
- meloxicam
- methicillin
- metrizamide
- mezlocillin
- mipomersen
- mumps virus vaccine
N
O
P
- pantoprazole
- penicillin g benzathine
- penicillin g potassium
- penicillin g sodium
- penicillin v potassium
- pexidartinib
- phenylbutazone
- piperacillin
- piroxicam
- poliovirus vaccine, live, trivalent
- ponesimod
- probenecid
- procaine penicillin
R
- rabeprazole
- radium 223 dichloride
- respiratory syncytial virus immune globulin
- rho (d) immune globulin
- ritlecitinib
- rotavirus vaccine
- rubella virus vaccine
S
- salsalate
- samarium sm 153 lexidronam
- siponimod
- sirolimus
- smallpox vaccine
- sodium salicylate
- sodium thiosalicylate
- strontium-89 chloride
- sulindac
T
- tacrolimus
- talimogene laherparepvec
- temsirolimus
- tenofovir alafenamide
- tenofovir disoproxil
- teriflunomide
- thalidomide
- ticarcillin
- tofacitinib
- tolmetin
- trimethoprim
- typhoid vaccine, live
U
V
Y
Z
Methotrexate alcohol/food interactions
There are 3 alcohol/food interactions with methotrexate.
Methotrexate disease interactions
There are 5 disease interactions with methotrexate which include:
More about methotrexate
- methotrexate consumer information
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- Patient tips
- During pregnancy
- Support group
- Drug class: antimetabolites
- Breastfeeding
Related treatment guides
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.