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Drug Interactions between Inlyta and megestrol

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

No interactions were found between Inlyta and megestrol. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Inlyta

A total of 214 drugs are known to interact with Inlyta.

megestrol

A total of 151 drugs are known to interact with megestrol.

Drug and food interactions

Moderate

axitinib food

Applies to: Inlyta (axitinib)

GENERALLY AVOID: Grapefruit juice may increase the plasma concentrations of axitinib. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruit.

MANAGEMENT: Patients treated with axitinib should avoid consumption of grapefruit, grapefruit juice, and any supplement containing grapefruit extract. Axitinib may be administered with or without food.

References

  1. "Product Information. Inlyta (axitinib)." Pfizer U.S. Pharmaceuticals Group (2012):

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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