Inlyta

Generic Name: axitinib (axIT i nib)
Brand Names: Inlyta

What is Inlyta?

Inlyta (axitinib) is a cancer medication that interferes with the growth and spread of cancer cells in the body.

Inlyta is used to treat cancer of the kidney.

Inlyta is usually given after other cancer medication has been tried without successful treatment.

Inlyta may also be used for purposes not listed in this medication guide.

Important information

Do not use Inlyta if you are pregnant. It could harm the unborn baby. Use birth control to prevent pregnancy while you are receiving Inlyta, whether you are a man or a woman. Inlyta use by either parent may cause birth defects or miscarriage. You should not use Inlyta if you are allergic to axitinib.

Before you take Inlyta, tell your doctor if you have liver or kidney disease, high blood pressure, a thyroid disorder, bleeding problems, an unhealed wound, stomach or intestinal bleeding, or a history of brain tumor, stroke, or blood clot.

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Inlyta is usually taken once every 12 hours. Inlyta should be taken at evenly spaced intervals. Follow your doctor's instructions.

To be sure this medication is not causing harmful effects, your kidney, thyroid, and liver function will need to be tested. Your blood pressure will also need to be checked often. Visit your doctor regularly.

If you need surgery, tell the surgeon ahead of time that you are using Inlyta. You may need to stop using the medicine for a short time. Stop using Inlyta and call your doctor at once if you have sudden weight loss, vision problems, confusion, sudden numbness or weakness, severe headache, feeling hot or cold, severe stomach pain, unusual bleeding, or seizure (convulsions).

Before taking this medicine

You should not use Inlyta if you are allergic to axitinib.

To make sure you can safely use Inlyta, tell your doctor if you have any of these other conditions:

  • liver disease;

  • kidney disease;

  • high blood pressure;

  • a thyroid disorder;

  • bleeding problems, or a wound that has not healed;

  • recent stomach or intestinal bleeding;

  • history of perforation (a hole or tear) in your stomach or intestines;

  • history of a brain tumor; or

  • a history of stroke or blood clot.

FDA pregnancy category D. Do not use Inlyta if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.

See also: Pregnancy and breastfeeding warnings (in more detail)

Use birth control to prevent pregnancy while you are receiving Inlyta, whether you are a man or a woman. Inlyta use by either parent may cause birth defects or miscarriage.

It is not known whether axitinib passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using Inlyta.

How should I take Inlyta?

Take Inlyta exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Inlyta is usually taken once every 12 hours. Follow your doctor's instructions.

Inlyta should be taken at evenly spaced intervals. You may take Inlyta with or without food.

Take this medicine with a full glass of water.

Your blood pressure will need to be checked often. Visit your doctor regularly.

To be sure Inlyta is not causing harmful effects, your kidney, thyroid, and liver function will need to be tested. Your cancer treatments may be delayed based on the results of these tests. Do not miss any follow up visits to your doctor for blood or urine tests. If you need surgery, tell the surgeon ahead of time that you are using Inlyta. You may need to stop using the medicine for a short time.

Store Inlyta at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include seizure (convulsions).

What should I avoid?

Grapefruit and grapefruit juice may interact with Inlyta and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor.

Inlyta side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Inlyta: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using Inlyta and call your doctor at once if you have a serious side effect such as:

  • sudden numbness or weakness, problems with speech or balance;

  • pain, swelling, warmth, or redness in one or both legs;

  • severe headache, confusion, change in mental status, vision loss, and/or seizure (convulsions);

  • severe stomach pain;

  • red or pink urine, bloody or tarry stools;

  • coughing up blood or vomit that looks like coffee grounds;

  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;

  • rash, blisters, oozing, or severe pain in the palms of your hands or the soles of your feet;

  • any wound that will not heal;

  • sudden weight loss, increased appetite, pounding heartbeats, fluttering in your chest, feeling very weak or tired, muscle pain, numbness or tingling in your hands, dry skin and hair, feeling hot or cold, changes in your menstrual periods, hoarse voice, swelling in your neck or throat (enlarged thyroid); or

  • dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, chest pain, shortness of breath, uneven heartbeats).

Less serious Inlyta side effects may include:

  • nausea, vomiting;

  • diarrhea, constipation; or

  • loss of appetite.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Inlyta?

Tell your doctor about all other medicines you use, especially:

  • boceprevir (Victrelis);

  • bosentan (Tracleer);

  • conivaptan (Vaprisol);

  • dexamethasone (Cortastat, Dexasone, Solurex, DexPak);

  • imatinib (Gleevec);

  • isoniazid (for treating tuberculosis);

  • nefazodone;

  • St. John's wort;

  • theophylline (Elixophyllin, Theochron, Uniphyl);

  • an antibiotic such as clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), rifabutin (Mycobutin), rifampin (Rifadin, Rifater, Rifamate), rifapentine (Priftin), or telithromycin (Ketek);

  • antifungal medication such as itraconazole (Sporanox), ketoconazole (Nizoral), miconazole (Oravig), or voriconazole (Vfend);

  • a barbiturate such as butabarbital (Butisol), secobarbital (Seconal), pentobarbital (Nembutal), or phenobarbital (Solfoton);

  • heart or blood pressure medication such as nicardipine (Cardene) or quinidine (Quin-G);

  • HIV/AIDS medication such as atazanavir (Reyataz), delavirdine (Rescriptor), efavirenz (Sustiva, Atripla), etravirine (Intelence), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, Kaletra), saquinavir (Invirase), or telaprevir (Incivek);

  • medicines to treat narcolepsy, such as armodafinil (Nuvigil) or modafinil (Progivil); or

  • seizure medication such as carbamazepine (Carbatrol, Equetro, Tegretol), felbamate (Felbatol), oxcarbazepine (Trileptal), phenytoin (Dilantin), or primidone (Mysoline).

There may be other drugs that can interact with Inlyta. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

  • Your pharmacist can provide more information about Inlyta.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2014 Cerner Multum, Inc. Version: 1.01. Revision Date: 2012-03-05, 10:36:22 AM.

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