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Drug Interactions between doxorubicin liposomal and streptozocin

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

streptozocin DOXOrubicin liposomal

Applies to: streptozocin and doxorubicin liposomal

MONITOR: The concomitant use of streptozocin and doxorubicin may prolong the elimination half-life of doxorubicin, and increase the risk of severe bone marrow suppression and hepatotoxicity.

MANAGEMENT: It is recommended to monitor patients for clinical and laboratory signs and symptoms of toxicity. The US manufacturer also suggests decreasing the dosage of doxorubicin.

References

  1. "Product Information. Zanosar (streptozocin)." Pharmacia and Upjohn PROD (2001):
  2. Agencia Española de Medicamentos y Productos Sanitarios Healthcare "Centro de información online de medicamentos de la AEMPS - CIMA. https://cima.aemps.es/cima/publico/home.html" (2008):

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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