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Drug Interactions between cefiderocol and daprodustat

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

cefiderocol daprodustat

Applies to: cefiderocol and daprodustat

MONITOR: Coadministration with inducers of CYP450 2C8 may decrease daprodustat plasma concentrations and may result in loss of efficacy. The proposed mechanism is induction of CYP450 2C8-mediated metabolism of daprodustat, which is primarily metabolized by the isoenzyme. However, data evaluating the interaction are not available.

MANAGEMENT: Increased monitoring of hemoglobin levels is advised following initiation or discontinuation of treatment with CYP450 2C8 inducers and the dupradustat dosage may be adjusted as necessary.

References

  1. (2023) "Product Information. Jesduvroq (daprodustat)." GlaxoSmithKline

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Drug and food interactions

Moderate

daprodustat food

Applies to: daprodustat

MONITOR: Smoking and alcohol consumption during therapy with daprodustat may increase the risk of gastric or esophageal erosions. Serious erosions, including gastrointestinal bleeding and the need for red blood cell transfusions, have been reported during daprodustat clinical trials. Patients with a history of gastrointestinal erosion, peptic ulcer disease, and current tobacco smokers and alcohol drinkers may be at higher risk of gastrointestinal injury.

MANAGEMENT: Caution is advised if daprodustat is prescribed to current tobacco smokers or alcohol drinkers. Patients should be advised to contact their physician if they develop potential signs and symptoms of gastrointestinal injury such as abdominal pain, hematemesis, trouble swallowing, chest or throat pain, and/or black, tarry stools.

References

  1. (2023) "Product Information. Jesduvroq (daprodustat)." GlaxoSmithKline

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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