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Daprodustat

Generic name: daprodustat [ DAP-roe-DOO-stat ]
Brand name: Jesduvroq
Dosage form: oral tablet (1 mg; 2 mg; 4 mg; 6 mg; 8 mg)
Drug class: Miscellaneous uncategorized agents

Medically reviewed by Drugs.com on Sep 28, 2023. Written by Cerner Multum.

What is daprodustat?

Daprodustat is used to treat anemia caused by chronic kidney disease in adults who have been on dialysis for at least 4 months.

Daprodustat may also be used for purposes not listed in this medication guide.

Daprodustat side effects

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

Daprodustat may cause serious side effects. Call your doctor at once if you have:

Common side effects of daprodustat may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Daprodustat side effects (more detail)

Warnings

Call your doctor at once if you have sudden numbness or weakness (especially on one side of the body), problems with vision or balance, shortness of breath, pain, swelling, or warmth in one leg, or if you do not feel a vibration in the dialysis access area.

Also call your doctor at once if you have stomach pain, bloody or tarry stools, nausea, vomit that looks like coffee grounds, trouble swallowing, chest or throat pain.

Before taking this medicine

You should not use daprodustat if you have:

Tell your doctor if you have or have ever had:

May harm an unborn baby. Do not use if you are pregnant. Tell your doctor if you become pregnant.

Do not breastfeed while using daprodustat, and for at least 1 week after your last dose.

How should I take daprodustat?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Ask your doctor before changing your dose or stopping daprodustat.

Take daprodustat once a day with or without food.

Swallow the tablet whole and do not crush, chew, or break it.

Using daprodustat may increase your risk of developing cancer. Ask your doctor about your individual risk.

Daprodustat may be taken at the same time as iron supplements or medicines that control the amount of phosphorus in your blood.

Your blood pressure will need to be checked often.

You will need blood tests before and during treatment with daprodustat, and your dose may change based on the results.

Store at room temperature away from moisture and heat.

Detailed Daprodustat dosage information

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include headache and nausea.

What should I avoid while taking daprodustat?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect daprodustat?

Sometimes it is not safe to use certain medicines at the same time. Some drugs can affect your blood levels of other drugs you use, which may increase side effects or make the medicines less effective.

Tell your doctor about all your other medicines, especially:

Other drugs may affect daprodustat, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

Daprodustat drug interactions (more detail)

Popular FAQ

The majority of patients with CKD will need to take iron supplements while they are taking Jesduvroq. Your doctor will determine if you need iron supplements by ordering a blood test that determines iron levels in your body. They will prescribe supplemental iron if your serum ferritin is less than 100 ng/ml or your serum transferrin saturation is less than 20%.

Jesduvroq can be taken with or without food, and concomitant iron or phosphate binders can be taken at the same time.

Clinical trials have compared Jesduvroq to intravenous epoetin alfa in those on hemodialysis (n=1 316, 88.5%), and subcutaneous darbepoetin alfa in those on peritoneal dialysis (n=171, 11%). The trials determined that Jesduvroq was non-inferior to these standard treatments with respect to the average change in hemoglobin levels. This essentially means it has the same effect as these other treatments.

Jesduvroq is used to raise hemoglobin levels and treat anemia associated with chronic kidney disease. It has not been proven to improve quality of life, tiredness (fatigue), or well-being.

Jesduvroq and Aranesp are both used to raise hemoglobin levels and to treat anemia associated with chronic kidney disease (CKD). However, they differ in their active ingredients, indications, ways of working in the body, routes, frequency of administration, side effect profiles, and warnings. Neither Jesduvroq nor Aranesp has been proven to improve quality of life, tiredness (fatigue), or well-being. Continue reading

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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