Daprodustat Side Effects
Medically reviewed by Drugs.com. Last updated on Oct 15, 2023.
Applies to daprodustat: oral tablet.
Warning
Oral route (Tablet)
Increased Risk of Death, Myocardial Infarction, Stroke, Venous Thromboembolism, and Thrombosis of Vascular AccessDaprodustat increases the risk of thrombotic vascular events, including major adverse cardiovascular events (MACE).Targeting a hemoglobin level greater than 11 g/dL is expected to further increase the risk of death and arterial venous thrombotic events, as occurs with erythropoietin stimulating agents (ESAs), which also increase erythropoietin levels.No trial has identified a hemoglobin target level, dose of daprodustat, or dosing strategy that does not increase these risks.Use the lowest dose of daprodustat sufficient to reduce the need for red blood cell transfusions.
Serious side effects of Daprodustat
Along with its needed effects, daprodustat may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking daprodustat:
More common
- Blurred vision
- chest tightness
- dizziness
- fever
- headache
- hoarseness
- irritation
- joint pain, stiffness, swelling
- nervousness
- pounding in the ears
- redness of the skin
- slow or fast heartbeat
- swelling of the eyelids, face, lips, hands, or feet
- tenderness, pain, swelling, warmth, skin discoloration, and prominent superficial veins over the affected area
- trouble breathing
- trouble swallowing
Less common
- Blood or black, tarry stools
- chest pain or discomfort
- confusion
- constipation
- difficulty in speaking
- double vision
- inability to move the arms, legs, or facial muscles
- inability to speak
- nausea
- pain or discomfort in the arms, jaws, back, or neck
- sever stomach pain
- slow speech
- sweating
- vomiting
- vomiting of blood material that looks like coffee grounds
Rare
Incidence not known
- Agitation
- back pain
- coma
- drowsiness
- hallucination
- mood or mental changes
- seizures
- stiff neck
- unusual tiredness or weakness
For Healthcare Professionals
Applies to daprodustat: oral tablet.
General
The most common adverse reactions observed in at least 10% of patients treated with this drug were hypertension, thrombotic vascular events, and abdominal pain. Nineteen percent of patients permanently discontinued this drug due to an adverse reaction.
Cardiovascular
Very common (10% or more): Hypertension (24%)[Ref]
Gastrointestinal
Abdominal pain included unspecified abdominal pain, upper abdominal pain, abdominal discomfort.[Ref]
Very common (10% or more): Abdominal pain (11%)[Ref]
Hematologic
Common (1% to 10%): Adjudicated thrombotic vascular events (deep vein thrombosis, myocardial infarction, pulmonary embolism, stroke, vascular access thrombosis)[Ref]
Hypersensitivity
Common (1% to 10%): Hypersensitivity[Ref]
Hypersensitivity included rash, urticaria and dermatitis.[Ref]
Nervous system
Common (1% to 10%): Dizziness[Ref]
Frequently asked questions
More about daprodustat
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- During pregnancy
- Drug class: miscellaneous uncategorized agents
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References
1. Product Information. Jesduvroq (daprodustat). GlaxoSmithKline. 2023.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.
