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Drug Interactions between Brilinta and coagulation factor viia

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

coagulation factor VIIa ticagrelor

Applies to: coagulation factor viia and Brilinta (ticagrelor)

Antifibrinolytic agents (e.g., aminocaproic acid or tranexamic acid) and recombinant factor VIIa may increase hemostasis and antagonize the effects of ticagrelor. They may be more effective in managing clinical bleeding events that occur during ticagrelor therapy compared to platelet infusions or desmopressin. No data exist regarding a hemostatic benefit of platelet transfusions in the presence of ticagrelor; circulating ticagrelor may inhibit transfused platelets. Template bleeding time did not decrease when ticagrelor was coadministered with desmopressin; therefore, desmopressin is unlikely to be effective in managing clinical bleeding events. Ticagrelor should be discontinued if active bleeding occurs, and may be resumed after the bleeding has been controlled and the cause identified.

References

  1. Cerner Multum, Inc. "UK Summary of Product Characteristics."
  2. (2011) "Product Information. Brilinta (ticagrelor)." Astra-Zeneca Pharmaceuticals

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.


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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.