Drug Interactions between Aspirin Low Strength and erythromycin
This report displays the potential drug interactions for the following 2 drugs:
- Aspirin Low Strength (aspirin)
- erythromycin
Interactions between your drugs
No interactions were found between Aspirin Low Strength and erythromycin. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Aspirin Low Strength
A total of 343 drugs are known to interact with Aspirin Low Strength.
- Aspirin low strength is in the following drug classes: platelet aggregation inhibitors, salicylates.
-
Aspirin low strength is used to treat the following conditions:
- Angina
- Angina Pectoris Prophylaxis
- Heart Attack
- Ischemic Stroke
- Ischemic Stroke, Prophylaxis
- Myocardial Infarction, Prophylaxis
- Niacin Flush
- Prevention of Thromboembolism in Atrial Fibrillation
- Prosthetic Heart Valves - Thrombosis Prophylaxis
- Prosthetic Heart Valves, Mechanical Valves - Thrombosis Prophylaxis
- Revascularization Procedures, Prophylaxis
- Spondyloarthritis
- Thromboembolic Stroke Prophylaxis
- Transient Ischemic Attack
erythromycin
A total of 641 drugs are known to interact with erythromycin.
- Erythromycin is in the drug class macrolides.
-
Erythromycin is used to treat the following conditions:
- Bacterial Endocarditis Prevention
- Bartonellosis
- Bowel Preparation
- Bronchitis
- Bullous Pemphigoid
- Campylobacter Gastroenteritis
- Chancroid
- Chlamydia Infection
- Dental Abscess
- Legionella Pneumonia
- Lyme Disease
- Lymphogranuloma Venereum
- Mycoplasma Pneumonia
- Nongonococcal Urethritis
- Ocular Rosacea
- Otitis Media
- Pemphigoid
- Pertussis
- Pharyngitis
- Pneumonia
- Rheumatic Fever Prophylaxis
- Skin and Structure Infection
- Skin or Soft Tissue Infection
- Strep Throat
- Syphilis, Early
- Upper Respiratory Tract Infection
Drug and food interactions
erythromycin food
Applies to: erythromycin
ADJUST DOSING INTERVAL: Food may variably affect the bioavailability of different oral formulations and salt forms of erythromycin. The individual product package labeling should be consulted regarding the appropriate time of administration in relation to food ingestion. Grapefruit juice may increase the plasma concentrations of orally administered erythromycin. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruits. In an open-label, crossover study consisting of six healthy subjects, the coadministration with double-strength grapefruit juice increased the mean peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of a single dose of erythromycin (400 mg) by 52% and 49%, respectively, compared to water. The half-life was not affected. The clinical significance of this potential interaction is unknown.
MANAGEMENT: In general, optimal serum levels are achieved when erythromycin is taken in the fasting state, one-half to two hours before meals. However, some erythromycin products may be taken without regard to meals.
References
- Welling PG, Huang H, Hewitt PF, Lyons LL "Bioavailability of erythromycin stearate: influence of food and fluid volume." J Pharm Sci 67 (1978): 764-6
- Welling PG, Elliott RL, Pitterle ME, et al. "Plasma levels following single and repeated doses of erythromycin estolate and erythromycin stearate." J Pharm Sci 68 (1979): 150-5
- Welling PG "Influence of food and diet on gastrointestinal drug absorption: a review." J Pharmacokinet Biopharm 5 (1977): 291-334
- Coyne TC, Shum S, Chun AH, Jeansonne L, Shirkey HC "Bioavailability of erythromycin ethylsuccinate in pediatric patients." J Clin Pharmacol 18 (1978): 194-202
- Malmborg AS "Effect of food on absorption of erythromycin. A study of two derivatives, the stearate and the base." J Antimicrob Chemother 5 (1979): 591-9
- Randinitis EJ, Sedman AJ, Welling PG, Kinkel AW "Effect of a high-fat meal on the bioavailability of a polymer-coated erythromycin particle tablet formulation." J Clin Pharmacol 29 (1989): 79-84
- Kanazawa S, Ohkubo T, Sugawara K "The effects of grapefruit juice on the pharmacokinetics of erythromycin." Eur J Clin Pharmacol 56 (2001): 799-803
aspirin food
Applies to: Aspirin Low Strength (aspirin)
GENERALLY AVOID: The concurrent use of aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) and ethanol may lead to gastrointestinal (GI) blood loss. The mechanism may be due to a combined local effect as well as inhibition of prostaglandins leading to decreased integrity of the GI lining.
MANAGEMENT: Patients should be counseled on this potential interaction and advised to refrain from alcohol consumption while taking aspirin or NSAIDs.
References
- "Product Information. Motrin (ibuprofen)." Pharmacia and Upjohn PROD (2002):
erythromycin food
Applies to: erythromycin
Ethanol, when combined with erythromycin, may delay absorption and therefore the clinical effects of the antibiotic. The mechanism appears to be due to slowed gastric emptying by ethanol. Data is available only for erythromycin ethylsuccinate. Patients should be advised to avoid ethanol while taking erythromycin salts.
References
- Morasso MI, Chavez J, Gai MN, Arancibia A "Influence of alcohol consumption on erythromycin ethylsuccinate kinetics." Int J Clin Pharmacol 28 (1990): 426-9
aspirin food
Applies to: Aspirin Low Strength (aspirin)
One study has reported that coadministration of caffeine and aspirin lead to a 25% increase in the rate of appearance and 17% increase in maximum concentration of salicylate in the plasma. A significantly higher area under the plasma concentration time curve of salicylate was also reported when both drugs were administered together. The exact mechanism of this interaction has not been specified. Physicians and patients should be aware that coadministration of aspirin and caffeine may lead to higher salicylate levels faster.
References
- Yoovathaworn KC, Sriwatanakul K, Thithapandha A "Influence of caffeine on aspirin pharmacokinetics." Eur J Drug Metab Pharmacokinet 11 (1986): 71-6
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Report options
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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