Excedrin PM Interactions
There are 530 drugs known to interact with Excedrin PM (acetaminophen / diphenhydramine), along with 11 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 22 are major, 494 are moderate, and 14 are minor.
- View all 530 medications that may interact with Excedrin PM
- View Excedrin PM alcohol/food interactions (1)
- View Excedrin PM disease interactions (11)
Most frequently checked interactions
View interaction reports for Excedrin PM (acetaminophen / diphenhydramine) and the medicines listed below.
- Advil (ibuprofen)
- Aleve (naproxen)
- alprazolam
- amoxicillin
- aspirin
- atorvastatin
- Benadryl (diphenhydramine)
- benzonatate
- buspirone
- clonazepam
- cyclobenzaprine
- Cymbalta (duloxetine)
- diphenhydramine
- Excedrin Extra Strength (acetaminophen / aspirin / caffeine)
- Excedrin Migraine (acetaminophen / aspirin / caffeine)
- gabapentin
- hydroxyzine
- ibuprofen
- lisinopril
- melatonin
- multivitamin
- naproxen
- sumatriptan
- tramadol
- Tylenol (acetaminophen)
- Vitamin B12 (cyanocobalamin)
- Vitamin C (ascorbic acid)
- Vitamin D3 (cholecalciferol)
- zolpidem
- Zyrtec (cetirizine)
Excedrin PM alcohol/food interactions
There is 1 alcohol/food interaction with Excedrin PM (acetaminophen / diphenhydramine).
Excedrin PM disease interactions
There are 11 disease interactions with Excedrin PM (acetaminophen / diphenhydramine) which include:
- alcoholism
- liver disease
- depression
- PKU
- anticholinergic effects
- asthma/COPD
- cardiovascular
- renal/liver disease
- glaucoma
- liver disease
- resp depression
More about Excedrin PM (acetaminophen / diphenhydramine)
- Compare alternatives
- Reviews (7)
- Drug images
- Side effects
- Dosage information
- During pregnancy
- Drug class: analgesic combinations
Related treatment guides
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.