Acetaminophen / Diphenhydramine Dosage

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Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Insomnia

Note: Acetaminophen-diphenhydramine is generally dosed based on the diphenhydramine component to equal 50 mg of diphenhydramine (76 mg diphenhydramine citrate) at bedtime.

Acetaminophen-diphenhydramine comes in several different dosages (500 mg-25 mg, 650 mg-50 mg, 500 mg-38 mg, 500 mg-12.5 mg, 1000 mg-50 mg, 500 mg-50 mg, 325 mg-12.5 mg) and is available as liquid, caplets, geltabs, and gelcaps. The manufacturer of these products generally advises 2 dosage units at bedtime or as directed by a healthcare professional.

Usual Adult Dose for Pain

Note: Acetaminophen-diphenhydramine is generally dosed based on the diphenhydramine component to equal 50 mg of diphenhydramine (76 mg diphenhydramine citrate) at bedtime.

Acetaminophen-diphenhydramine comes in several different dosages (500 mg-25 mg, 650 mg-50 mg, 500 mg-38 mg, 500 mg-12.5 mg, 1000 mg-50 mg, 500 mg-50 mg, 325 mg-12.5 mg) and is available as liquid, caplets, geltabs, and gelcaps. The manufacturer of these products generally advises 2 dosage units at bedtime or as directed by a healthcare professional.

Usual Adult Dose for Headache

Note: Acetaminophen-diphenhydramine is generally dosed based on the diphenhydramine component to equal 50 mg of diphenhydramine (76 mg diphenhydramine citrate) at bedtime.

Acetaminophen-diphenhydramine comes in several different dosages (500 mg-25 mg, 650 mg-50 mg, 500 mg-38 mg, 500 mg-12.5 mg, 1000 mg-50 mg, 500 mg-50 mg, 325 mg-12.5 mg) and is available as liquid, caplets, geltabs, and gelcaps. The manufacturer of these products generally advises 2 dosage units at bedtime or as directed by a healthcare professional.

Usual Pediatric Dose for Insomnia

Greater than or equal to 12 years:

Note: Acetaminophen-diphenhydramine is generally dosed based on the diphenhydramine component to equal 50 mg of diphenhydramine (76 mg diphenhydramine citrate) at bedtime.

Acetaminophen-diphenhydramine comes in several different dosages (500 mg-25 mg, 650 mg-50 mg, 500 mg-38 mg, 500 mg-12.5 mg, 1000 mg-50 mg, 500 mg-50 mg, 325 mg-12.5 mg) and is available as liquid, caplets, geltabs, and gelcaps. The manufacturer of these products generally advises 2 dosage units at bedtime or as directed by a healthcare professional.

Usual Pediatric Dose for Pain

Greater than or equal to 12 years:

Note: Acetaminophen-diphenhydramine is generally dosed based on the diphenhydramine component to equal 50 mg of diphenhydramine (76 mg diphenhydramine citrate) at bedtime.

Acetaminophen-diphenhydramine comes in several different dosages (500 mg-25 mg, 650 mg-50 mg, 500 mg-38 mg, 500 mg-12.5 mg, 1000 mg-50 mg, 500 mg-50 mg, 325 mg-12.5 mg) and is available as liquid, caplets, geltabs, and gelcaps. The manufacturer of these products generally advises 2 dosage units at bedtime or as directed by a healthcare professional.

Usual Pediatric Dose for Headache

Greater than or equal to 12 years:

Note: Acetaminophen-diphenhydramine is generally dosed based on the diphenhydramine component to equal 50 mg of diphenhydramine (76 mg diphenhydramine citrate) at bedtime.

Acetaminophen-diphenhydramine comes in several different dosages (500 mg-25 mg, 650 mg-50 mg, 500 mg-38 mg, 500 mg-12.5 mg, 1000 mg-50 mg, 500 mg-50 mg, 325 mg-12.5 mg) and is available as liquid, caplets, geltabs, and gelcaps. The manufacturer of these products generally advises 2 dosage units at bedtime or as directed by a healthcare professional.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Use with caution in patients with liver disease. Chronic use of acetaminophen is not recommended in patients with liver disease.

Precautions

Patients who consume three or more alcohol containing drinks per day should be informed to consult with their physician for advice on when and how to take acetaminophen. Chronic, heavy alcohol users may be at increased risk of liver damage when taking more than recommended dosages.

Patients and adults taking care of children should be advised to consult with their doctor before continuing to use acetaminophen if symptoms of illness worsen. Although rare, there is the possibility of acetaminophen intoxication on chronic use of the drug, and the symptoms seen during the first phase of intoxication (nausea, vomiting, anorexia, malaise, and diaphoresis) may trigger the use of more doses.

Patients should be warned of the sedative effects of diphenhydramine, and advised not to take this drug with alcohol.

Due to the anticholinergic effect of diphenhydramine, it should be used with caution in patients with narrow-angle glaucoma, stenosing peptic ulcer, pyloroduodenal obstruction, prostatic hypertrophy or bladder neck obstructions. It should also be used with caution in patients with increased intraocular pressure, hyperthyroidism, cardiovascular disease, or hypertension.

Dialysis

Data not available

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