Acetaminophen/butalbital/caffeine/codeine Drug Interactions
Currently displaying 660 drugs known to have a moderate interaction with acetaminophen / butalbital / caffeine / codeine.
Moderate interactions with acetaminophen / butalbital / caffeine / codeine
Note: Showing generic names only.
5
A
- abametapir topical
- abemaciclib
- abiraterone
- abrocitinib
- acalabrutinib
- acebutolol
- acrivastine
- adagrasib
- adenosine
- albuterol
- aldesleukin
- alfuzosin
- allopurinol
- almotriptan
- alosetron
- alpelisib
- altretamine
- amifampridine
- amiloride
- aminophylline
- amiodarone
- amisulpride
- amitriptyline
- amlodipine
- amoxapine
- amphetamine
- amprenavir
- amyl nitrite
- anagrelide
- apalutamide
- apixaban
- apomorphine
- apraclonidine ophthalmic
- apremilast
- aprepitant
- aprocitentan
- arformoterol
- armodafinil
- asparaginase erwinia chrysanthemi
- asparaginase escherichia coli
- atazanavir
- atenolol
- atomoxetine
- atorvastatin
- atropine
- attapulgite
- avacopan
- avanafil
- avapritinib
- axitinib
- azatadine
- azelastine nasal
- azilsartan medoxomil
B
- baricitinib
- bedaquiline
- belladonna
- belumosudil
- belzutifan
- benazepril
- bendamustine
- bendroflumethiazide
- benzphetamine
- benzthiazide
- benztropine
- bepridil
- berotralstat
- betamethasone
- betaxolol
- biperiden
- bismuth subgallate
- bismuth subsalicylate
- bisoprolol
- bitolterol
- black cohosh
- boceprevir
- bosentan
- bosutinib
- brentuximab
- brigatinib
- brimonidine ophthalmic
- brimonidine topical
- brivaracetam
- bromocriptine
- brompheniramine
- budesonide
- bumetanide
- bupivacaine
- bupivacaine liposome
- busulfan
C
- cabazitaxel
- cabozantinib
- calaspargase pegol
- calcifediol
- calcitriol
- canagliflozin
- candesartan
- cannabidiol
- capivasertib
- capmatinib
- captopril
- carbamazepine
- carbetapentane
- carbinoxamine
- carteolol
- carvedilol
- caspofungin
- celecoxib
- cenobamate
- ceritinib
- cetirizine
- charcoal
- chlophedianol
- chloramphenicol
- chlorcyclizine
- chloroprocaine
- chloroquine
- chlorothiazide
- chlorotrianisene
- chlorpheniramine
- chlorthalidone
- cholecalciferol
- cimetidine
- cinacalcet
- ciprofloxacin
- citalopram
- clemastine
- clevidipine
- clidinium
- clofarabine
- clomipramine
- clonidine
- clopidogrel
- cobicistat
- cobimetinib
- conjugated estrogens
- copanlisib
- corticorelin
- corticotropin
- cortisone
- cosyntropin
- crizotinib
- cyclizine
- cycloserine
- cyclosporine
- cyproheptadine
D
- dabrafenib
- daclizumab
- dacomitinib
- darifenacin
- darolutamide
- darunavir
- dasatinib
- deferasirox
- delavirdine
- deserpidine
- desflurane
- desipramine
- desmopressin
- desvenlafaxine
- deutetrabenazine
- dexamethasone
- dexbrompheniramine
- dexchlorpheniramine
- dexfenfluramine
- dexmedetomidine
- dexmethylphenidate
- dextroamphetamine
- dextromethorphan
- diazoxide
- dicyclomine
- diethylpropion
- difelikefalin
- digitoxin
- dihydroergotamine
- dihydrotachysterol
- diltiazem
- dimenhydrinate
- diphenhydramine
- dipyridamole
- disopyramide
- divalproex sodium
- dobutamine
- docetaxel
- dolasetron
- donepezil
- dopamine
- doravirine
- doxapram
- doxazosin
- doxepin
- doxepin topical
- doxercalciferol
- doxorubicin
- doxorubicin liposomal
- doxycycline
- doxylamine
- dronabinol
- dronedarone
- drospirenone
- duloxetine
E
- echinacea
- efavirenz
- elacestrant
- elagolix
- eletriptan
- eliglustat
- eluxadoline
- enalapril
- enalaprilat
- encorafenib
- enflurane
- enoxacin
- entacapone
- entrectinib
- enzalutamide
- ephedrine
- epinephrine
- epirubicin
- eplerenone
- eprosartan
- ergocalciferol
- ergonovine
- ergotamine
- erlotinib
- escitalopram
- eslicarbazepine
- esmolol
- esterified estrogens
- estradiol
- estradiol topical
- estrone
- estropipate
- ethacrynic acid
- ethinyl estradiol
- ethosuximide
- ethotoin
- etidocaine
- etonogestrel
- etranacogene dezaparvovec
- etravirine
- everolimus
- exemestane
- ezogabine
F
- fedratinib
- felbamate
- felodipine
- fenfluramine
- fenofibrate
- fenoldopam
- fesoterodine
- fexinidazole
- fidanacogene elaparvovec
- finerenone
- flavoxate
- flibanserin
- fludrocortisone
- fluoxetine
- fluvoxamine
- formoterol
- fosamprenavir
- fosaprepitant
- fosinopril
- fosphenytoin
- fospropofol
- fostamatinib
- frovatriptan
- furosemide
G
- ganaxolone
- gefitinib
- gepirone
- gilteritinib
- ginkgo
- givosiran
- glasdegib
- glycerol phenylbutyrate
- glycopyrrolate
- goldenseal
- granisetron
- grepafloxacin
- griseofulvin
- guanabenz
- guanadrel
- guanethidine
- guanfacine
H
- halofantrine
- halothane
- hydralazine
- hydrochlorothiazide
- hydrocortisone
- hydroflumethiazide
- hydroxychloroquine
- hydroxyprogesterone
- hyoscyamine
I
- ibrutinib
- idelalisib
- ifosfamide
- imatinib
- imipramine
- indacaterol
- indapamide
- indinavir
- indocyanine green
- infigratinib
- interferon beta-1a
- interferon beta-1b
- irbesartan
- irinotecan
- irinotecan liposomal
- isavuconazonium
- isoetharine
- isoflurane
- isoniazid
- isoproterenol
- isosorbide dinitrate
- isosorbide mononitrate
- isradipine
- ivabradine
- ivacaftor
- ixabepilone
- ixazomib
K
L
- labetalol
- lamotrigine
- lapatinib
- larotrectinib
- lasmiditan
- lefamulin
- lenacapavir
- leniolisib
- lesinurad
- levalbuterol
- levamlodipine
- levetiracetam
- levobupivacaine
- levocetirizine
- levodopa
- levomilnacipran
- levonorgestrel
- levothyroxine
- levothyroxine / liothyronine
- lidocaine
- linagliptin
- lindane topical
- liothyronine
- liotrix
- lisdexamfetamine
- lisinopril
- lithium
- lofexidine
- lonafarnib
- lonapegsomatropin
- loperamide
- lorcaserin
- lorlatinib
- losartan
M
- ma huang
- macimorelin
- macitentan
- maprotiline
- maraviroc
- maribavir
- mavacamten
- mazindol
- mebrofenin
- meclizine
- medroxyprogesterone
- mefloquine
- megestrol
- melatonin
- mepenzolate
- mephentermine
- mephenytoin
- mepivacaine
- metaproterenol
- metaraminol
- methamphetamine
- methdilazine
- methohexital
- methotrexate
- methotrimeprazine
- methoxamine
- methoxyflurane
- methscopolamine
- methsuximide
- methyclothiazide
- methyldopa
- methylergonovine
- methylphenidate
- methylprednisolone
- methysergide maleate
- metoclopramide
- metolazone
- metoprolol
- metronidazole
- metyrosine
- mibefradil
- midazolam
- midostaurin
- mifepristone
- milnacipran
- minoxidil
- mirabegron
- mirtazapine
- mitotane
- mobocertinib
- modafinil
- moexipril
- montelukast
N
- nabilone
- nadolol
- nafcillin
- nalidixic acid
- naloxegol
- naloxone
- naratriptan
- nebivolol
- nefazodone
- nelfinavir
- nevirapine
- nicardipine
- nifedipine
- nilotinib
- nimodipine
- nirogacestat
- nisoldipine
- nitisinone
- nitroglycerin
- nitroprusside
- nitrous oxide
- norepinephrine
- norethindrone
- norfloxacin
- norgestrel
- nortriptyline
O
- obeticholic acid
- olaparib
- olmesartan
- olodaterol
- olopatadine nasal
- olutasidenib
- omaveloxolone
- ondansetron
- opicapone
- opium
- osilodrostat
- osimertinib
- ospemifene
- oxamniquine
- oxcarbazepine
- oxtriphylline
- oxybutynin
- ozanimod
P
- paclitaxel
- paclitaxel protein-bound
- pacritinib
- palbociclib
- palonosetron
- palovarotene
- panobinostat
- papaverine
- paramethadione
- paricalcitol
- paroxetine
- pazopanib
- pegaspargase
- peginterferon beta-1a
- pegvisomant
- pemigatinib
- penbutolol
- perampanel
- pergolide
- perindopril
- phenacemide
- phendimetrazine
- phenindamine
- phenoxybenzamine
- phensuximide
- phentermine
- phentolamine
- phenylephrine
- phenylpropanolamine
- phenytoin
- pindolol
- pirbuterol
- pirtobrutinib
- pitolisant
- pneumococcal 13-valent vaccine
- pneumococcal 15-valent conjugate vaccine
- pneumococcal 20-valent conjugate vaccine
- pneumococcal 21-valent conjugate vaccine
- pneumococcal 7-valent vaccine
- polyethylene glycol 3350 with electrolytes
- polythiazide
- ponatinib
- pralsetinib
- pramipexole
- prasugrel
- praziquantel
- prazosin
- prednisolone
- prednisone
- primaquine
- procaine
- prochlorperazine
- procyclidine
- progesterone
- progesterone topical
- promethazine
- propafenone
- propantheline
- propofol
- propranolol
- protriptyline
- pseudoephedrine
- pyrilamine
Q
R
- racepinephrine
- ramipril
- rauwolfia serpentina
- regadenoson
- remdesivir
- repaglinide
- repotrectinib
- reserpine
- ribociclib
- rifabutin
- rifampin
- rifapentine
- rilpivirine
- riociguat
- ripretinib
- ritlecitinib
- ritodrine
- ritonavir
- rivaroxaban
- rizatriptan
- rolapitant
- ropeginterferon alfa-2b
- ropinirole
- ropivacaine
- rotigotine
- rucaparib
- rufinamide
- ruxolitinib
S
- safinamide
- salmeterol
- saquinavir
- saxagliptin
- scopolamine
- selpercatinib
- selumetinib
- sertraline
- sevoflurane
- sibutramine
- silodosin
- sirolimus
- sirolimus protein-bound
- sodium polystyrene sulfonate
- solifenacin
- somapacitan-beco
- somatrem
- somatrogon
- somatropin
- sonidegib
- sorafenib
- sotalol
- sotorasib
- sparsentan
- spironolactone
- st. john's wort
- stiripentol
- sulfinpyrazone
- sumatriptan
- sunitinib
T
- tacrolimus
- tadalafil
- tafamidis
- tamoxifen
- tamsulosin
- tazemetostat
- tebentafusp
- telaprevir
- telithromycin
- telmisartan
- telotristat
- temsirolimus
- tepotinib
- terazosin
- terbinafine
- terbutaline
- tetrabenazine
- tetracaine
- thalidomide
- theophylline
- thiabendazole
- thiethylperazine
- thioguanine
- thiopental
- thyroid desiccated
- tiagabine
- ticagrelor
- ticlopidine
- timolol
- tinidazole
- tipranavir
- tirzepatide
- tofacitinib
- tolcapone
- tolterodine
- tolvaptan
- topiramate
- toremifene
- torsemide
- trabectedin
- trandolapril
- trazodone
- triamcinolone
- triamterene
- trichlormethiazide
- trihexyphenidyl
- trimeprazine
- trimethadione
- trimethaphan camsylate
- trimethobenzamide
- trimipramine
- tripelennamine
- triprolidine
- trofinetide
- troglitazone
- trospium
- tryptophan
- tucatinib
U
V
- valbenazine
- valerian
- valoctocogene roxaparvovec
- valproic acid
- valsartan
- vemurafenib
- venetoclax
- venlafaxine
- verapamil
- vigabatrin
- vilazodone
- viloxazine
- voriconazole
- vortioxetine
Z
Acetaminophen/butalbital/caffeine/codeine alcohol/food interactions
There are 6 alcohol/food interactions with acetaminophen / butalbital / caffeine / codeine.
Acetaminophen/butalbital/caffeine/codeine disease interactions
There are 39 disease interactions with acetaminophen / butalbital / caffeine / codeine which include:
- alcoholism
- liver disease
- acute alcohol intoxication
- drug dependence
- liver disease
- porphyria
- rash
- respiratory depression
- cardiac disease
- hypertension
- psychiatric disorders
- PUD
- impaired GI motility
- infectious diarrhea
- prematurity
- acute alcohol intoxication
- drug dependence
- hypotension
- intracranial pressure
- respiratory depression
- gastrointestinal obstruction
- PKU
- adrenal insufficiency
- depression
- hematologic toxicity
- osteomalacia
- paradoxical reactions
- cardiotoxicity
- liver disease
- renal dysfunction
- seizure disorders
- GERD
- adrenal insufficiency
- liver disease
- renal dysfunction
- seizure disorders
- urinary retention
- arrhythmias
- biliary tract disease
More about acetaminophen / butalbital / caffeine / codeine
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Related treatment guides
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.