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Voriconazole Dosage

Medically reviewed by Drugs.com. Last updated on Jan 20, 2023.

Applies to the following strengths: 40 mg/mL; 50 mg; 200 mg

Usual Adult Dose for Aspergillosis - Invasive

Loading Dose: 6 mg/kg IV every 12 hours for the first 24 hours

Maintenance Dose (after first 24 hours):
IV:


Oral:

Comments:

Uses:

Infectious Diseases Society of America (IDSA) Recommendations: 6 mg/kg IV every 12 hours for 1 day, followed by 4 mg/kg IV every 12 hours

Comments:

Usual Adult Dose for Candidemia

Loading Dose: 6 mg/kg IV every 12 hours for the first 24 hours

Maintenance Dose (after first 24 hours):
IV:


Oral:

Comments:

Uses:

Infectious Diseases Society of America (IDSA) Recommendations: 6 mg/kg IV every 12 hours for 1 day, followed by 4 mg/kg IV every 12 hours

Comments:

Usual Adult Dose for Fungal Pneumonia

Loading Dose: 6 mg/kg IV every 12 hours for the first 24 hours

Maintenance Dose (after first 24 hours):
IV:


Oral:

Comments:

Uses:

Infectious Diseases Society of America (IDSA) Recommendations: 6 mg/kg IV every 12 hours for 1 day, followed by 4 mg/kg IV every 12 hours

Comments:

Usual Adult Dose for Pseudoallescheriosis

Loading Dose: 6 mg/kg IV every 12 hours for the first 24 hours

Maintenance Dose (after first 24 hours):
IV:


Oral:

Comments:

Uses:

Infectious Diseases Society of America (IDSA) Recommendations: 6 mg/kg IV every 12 hours for 1 day, followed by 4 mg/kg IV every 12 hours

Comments:

Usual Adult Dose for Systemic Fungal Infection

Loading Dose: 6 mg/kg IV every 12 hours for the first 24 hours

Maintenance Dose (after first 24 hours):
IV:


Oral:

Comments:

Uses:

Infectious Diseases Society of America (IDSA) Recommendations: 6 mg/kg IV every 12 hours for 1 day, followed by 4 mg/kg IV every 12 hours

Comments:

Usual Adult Dose for Cutaneous Fungal Infection

Loading Dose: 6 mg/kg IV every 12 hours for the first 24 hours

Maintenance Dose (after first 24 hours):
IV:


Oral:

Comments:

Uses:

Infectious Diseases Society of America (IDSA) Recommendations: 6 mg/kg IV every 12 hours for 1 day, followed by 4 mg/kg IV every 12 hours

Comments:

Usual Adult Dose for Fungal Infection - Disseminated

Loading Dose: 6 mg/kg IV every 12 hours for the first 24 hours

Maintenance Dose (after first 24 hours):
IV:


Oral:

Comments:

Uses:

Infectious Diseases Society of America (IDSA) Recommendations: 6 mg/kg IV every 12 hours for 1 day, followed by 4 mg/kg IV every 12 hours

Comments:

Usual Adult Dose for Fungal Meningitis

Loading Dose: 6 mg/kg IV every 12 hours for the first 24 hours

Maintenance Dose (after first 24 hours):
IV:


Oral:

Comments:

Uses:

Infectious Diseases Society of America (IDSA) Recommendations: 6 mg/kg IV every 12 hours for 1 day, followed by 4 mg/kg IV every 12 hours

Comments:

Usual Adult Dose for Fusariosis

Loading Dose: 6 mg/kg IV every 12 hours for the first 24 hours

Maintenance Dose (after first 24 hours):
IV:


Oral:

Comments:

Uses:

Infectious Diseases Society of America (IDSA) Recommendations: 6 mg/kg IV every 12 hours for 1 day, followed by 4 mg/kg IV every 12 hours

Comments:

Usual Adult Dose for Esophageal Candidiasis

Less than 40 kg: 100 mg orally every 12 hours
At least 40 kg: 200 mg orally every 12 hours

Duration of therapy: At least 14 days and at least 7 days after symptoms resolve

Use: For the treatment of esophageal candidiasis

Usual Adult Dose for Blastomycosis

IDSA Recommendations: 200 to 400 mg orally twice a day
Duration of therapy: At least 12 months and until CSF abnormalities resolve

Comments:

Usual Pediatric Dose for Aspergillosis - Invasive

PEDIATRIC PATIENTS 2 TO LESS THAN 12 YEARS AND PEDIATRIC PATIENTS 12 TO 14 YEARS WEIGHING LESS THAN 50 kg:
Loading Dose: 9 mg/kg IV every 12 hours for the first 24 hours

Maintenance Dose:


PEDIATRIC PATIENTS 12 TO 14 YEARS WEIGHING AT LEAST 50 kg AND PEDIATRIC PATIENTS 15 YEARS OR OLDER:
Loading Dose: 6 mg/kg IV every 12 hours for the first 24 hours

Maintenance Dose (after first 24 hours):
IV:

Oral:

COMMENTS:

Pediatric Patients 2 to Less Than 12 Years and Pediatric Patients 12 to 14 Years Weighing Less Than 50 kg:

Pediatric Patients 12 to 14 Years Weighing at Least 50 kg and Pediatric Patients 15 Years or Older:

Uses:

Usual Pediatric Dose for Candidemia

PEDIATRIC PATIENTS 2 TO LESS THAN 12 YEARS AND PEDIATRIC PATIENTS 12 TO 14 YEARS WEIGHING LESS THAN 50 kg:
Loading Dose: 9 mg/kg IV every 12 hours for the first 24 hours

Maintenance Dose:


PEDIATRIC PATIENTS 12 TO 14 YEARS WEIGHING AT LEAST 50 kg AND PEDIATRIC PATIENTS 15 YEARS OR OLDER:
Loading Dose: 6 mg/kg IV every 12 hours for the first 24 hours

Maintenance Dose (after first 24 hours):
IV:

Oral:

COMMENTS:

Pediatric Patients 2 to Less Than 12 Years and Pediatric Patients 12 to 14 Years Weighing Less Than 50 kg:

Pediatric Patients 12 to 14 Years Weighing at Least 50 kg and Pediatric Patients 15 Years or Older:

Uses:

Usual Pediatric Dose for Fungal Pneumonia

PEDIATRIC PATIENTS 2 TO LESS THAN 12 YEARS AND PEDIATRIC PATIENTS 12 TO 14 YEARS WEIGHING LESS THAN 50 kg:
Loading Dose: 9 mg/kg IV every 12 hours for the first 24 hours

Maintenance Dose:


PEDIATRIC PATIENTS 12 TO 14 YEARS WEIGHING AT LEAST 50 kg AND PEDIATRIC PATIENTS 15 YEARS OR OLDER:
Loading Dose: 6 mg/kg IV every 12 hours for the first 24 hours

Maintenance Dose (after first 24 hours):
IV:

Oral:

COMMENTS:

Pediatric Patients 2 to Less Than 12 Years and Pediatric Patients 12 to 14 Years Weighing Less Than 50 kg:

Pediatric Patients 12 to 14 Years Weighing at Least 50 kg and Pediatric Patients 15 Years or Older:

Uses:

Usual Pediatric Dose for Pseudoallescheriosis

PEDIATRIC PATIENTS 2 TO LESS THAN 12 YEARS AND PEDIATRIC PATIENTS 12 TO 14 YEARS WEIGHING LESS THAN 50 kg:
Loading Dose: 9 mg/kg IV every 12 hours for the first 24 hours

Maintenance Dose:


PEDIATRIC PATIENTS 12 TO 14 YEARS WEIGHING AT LEAST 50 kg AND PEDIATRIC PATIENTS 15 YEARS OR OLDER:
Loading Dose: 6 mg/kg IV every 12 hours for the first 24 hours

Maintenance Dose (after first 24 hours):
IV:

Oral:

COMMENTS:

Pediatric Patients 2 to Less Than 12 Years and Pediatric Patients 12 to 14 Years Weighing Less Than 50 kg:

Pediatric Patients 12 to 14 Years Weighing at Least 50 kg and Pediatric Patients 15 Years or Older:

Uses:

Usual Pediatric Dose for Systemic Fungal Infection

PEDIATRIC PATIENTS 2 TO LESS THAN 12 YEARS AND PEDIATRIC PATIENTS 12 TO 14 YEARS WEIGHING LESS THAN 50 kg:
Loading Dose: 9 mg/kg IV every 12 hours for the first 24 hours

Maintenance Dose:


PEDIATRIC PATIENTS 12 TO 14 YEARS WEIGHING AT LEAST 50 kg AND PEDIATRIC PATIENTS 15 YEARS OR OLDER:
Loading Dose: 6 mg/kg IV every 12 hours for the first 24 hours

Maintenance Dose (after first 24 hours):
IV:

Oral:

COMMENTS:

Pediatric Patients 2 to Less Than 12 Years and Pediatric Patients 12 to 14 Years Weighing Less Than 50 kg:

Pediatric Patients 12 to 14 Years Weighing at Least 50 kg and Pediatric Patients 15 Years or Older:

Uses:

Usual Pediatric Dose for Cutaneous Fungal Infection

PEDIATRIC PATIENTS 2 TO LESS THAN 12 YEARS AND PEDIATRIC PATIENTS 12 TO 14 YEARS WEIGHING LESS THAN 50 kg:
Loading Dose: 9 mg/kg IV every 12 hours for the first 24 hours

Maintenance Dose:


PEDIATRIC PATIENTS 12 TO 14 YEARS WEIGHING AT LEAST 50 kg AND PEDIATRIC PATIENTS 15 YEARS OR OLDER:
Loading Dose: 6 mg/kg IV every 12 hours for the first 24 hours

Maintenance Dose (after first 24 hours):
IV:

Oral:

COMMENTS:

Pediatric Patients 2 to Less Than 12 Years and Pediatric Patients 12 to 14 Years Weighing Less Than 50 kg:

Pediatric Patients 12 to 14 Years Weighing at Least 50 kg and Pediatric Patients 15 Years or Older:

Uses:

Usual Pediatric Dose for Fungal Infection - Disseminated

PEDIATRIC PATIENTS 2 TO LESS THAN 12 YEARS AND PEDIATRIC PATIENTS 12 TO 14 YEARS WEIGHING LESS THAN 50 kg:
Loading Dose: 9 mg/kg IV every 12 hours for the first 24 hours

Maintenance Dose:


PEDIATRIC PATIENTS 12 TO 14 YEARS WEIGHING AT LEAST 50 kg AND PEDIATRIC PATIENTS 15 YEARS OR OLDER:
Loading Dose: 6 mg/kg IV every 12 hours for the first 24 hours

Maintenance Dose (after first 24 hours):
IV:

Oral:

COMMENTS:

Pediatric Patients 2 to Less Than 12 Years and Pediatric Patients 12 to 14 Years Weighing Less Than 50 kg:

Pediatric Patients 12 to 14 Years Weighing at Least 50 kg and Pediatric Patients 15 Years or Older:

Uses:

Usual Pediatric Dose for Fungal Meningitis

PEDIATRIC PATIENTS 2 TO LESS THAN 12 YEARS AND PEDIATRIC PATIENTS 12 TO 14 YEARS WEIGHING LESS THAN 50 kg:
Loading Dose: 9 mg/kg IV every 12 hours for the first 24 hours

Maintenance Dose:


PEDIATRIC PATIENTS 12 TO 14 YEARS WEIGHING AT LEAST 50 kg AND PEDIATRIC PATIENTS 15 YEARS OR OLDER:
Loading Dose: 6 mg/kg IV every 12 hours for the first 24 hours

Maintenance Dose (after first 24 hours):
IV:

Oral:

COMMENTS:

Pediatric Patients 2 to Less Than 12 Years and Pediatric Patients 12 to 14 Years Weighing Less Than 50 kg:

Pediatric Patients 12 to 14 Years Weighing at Least 50 kg and Pediatric Patients 15 Years or Older:

Uses:

Usual Pediatric Dose for Fusariosis

PEDIATRIC PATIENTS 2 TO LESS THAN 12 YEARS AND PEDIATRIC PATIENTS 12 TO 14 YEARS WEIGHING LESS THAN 50 kg:
Loading Dose: 9 mg/kg IV every 12 hours for the first 24 hours

Maintenance Dose:


PEDIATRIC PATIENTS 12 TO 14 YEARS WEIGHING AT LEAST 50 kg AND PEDIATRIC PATIENTS 15 YEARS OR OLDER:
Loading Dose: 6 mg/kg IV every 12 hours for the first 24 hours

Maintenance Dose (after first 24 hours):
IV:

Oral:

COMMENTS:

Pediatric Patients 2 to Less Than 12 Years and Pediatric Patients 12 to 14 Years Weighing Less Than 50 kg:

Pediatric Patients 12 to 14 Years Weighing at Least 50 kg and Pediatric Patients 15 Years or Older:

Uses:

Usual Pediatric Dose for Esophageal Candidiasis

Pediatric Patients 2 to Less Than 12 Years and Pediatric Patients 12 to 14 Years Weighing Less Than 50 kg:


Pediatric Patients 12 to 14 Years Weighing at Least 50 kg and Pediatric Patients 15 Years or Older:
Duration of therapy: At least 14 days and at least 7 days after symptoms resolve

COMMENTS:

Pediatric Patients 2 to Less Than 12 Years and Pediatric Patients 12 to 14 Years Weighing Less Than 50 kg:

Use: For the treatment of esophageal candidiasis

Renal Dose Adjustments

Adult Patients:
IV:


Oral:

Pediatric Patients:

Comments:

Liver Dose Adjustments

Adult Patients:
Mild to moderate liver dysfunction (Child-Pugh A and B): The maintenance dose should be reduced.
Severe liver dysfunction: Data not available

Baseline liver function tests (ALT, AST) up to 5 times the upper limit of normal (5 x ULN): No adjustment recommended

Mild to moderate liver cirrhosis (Child-Pugh A and B):

Severe liver cirrhosis (Child-Pugh C), chronic HBV infection, or chronic HCV infection: Data not available

Pediatric Patients:

Comments:

Dose Adjustments

ADULT PATIENTS:
If patient is unable to tolerate 4 mg/kg IV every 12 hours, the IV maintenance dose should be reduced to 3 mg/kg IV every 12 hours.

If patient response is inadequate, the oral maintenance dose may be increased to:


If patient is unable to tolerate the higher dose, the oral maintenance dose should be reduced by 50 mg steps to a minimum of:

PEDIATRIC PATIENTS:
Pediatric Patients 2 to Less Than 12 Years and Pediatric Patients 12 to 14 Years Weighing Less Than 50 kg:

Pediatric Patients 12 to 14 Years Weighing at Least 50 kg and Pediatric Patients 15 Years or Older: The optimal method for titrating dosage recommended for adults should be used.

COADMINISTRATION WITH PHENYTOIN OR EFAVIRENZ:

Precautions

CONTRAINDICATIONS:


Safety and efficacy have not been established in patients younger than 2 years; this drug is not recommended for use in these patients.

Consult WARNINGS section for additional precautions.

Dialysis

Adult Patients:


Comments:

Other Comments

Administration advice:


Storage requirements:

Reconstitution/preparation techniques:

IV compatibility:

General:

Monitoring:

Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.