Generic Name: voriconazole (VOR-i-KON-a-zole)
Brand Name: Vfend
Voriconazole tablets are used for:
Treating certain fungal infections.
Voriconazole tablets are an azole antifungal. It works by blocking fungal cell wall growth, resulting in the death of the fungus.
Do NOT use voriconazole tablets if:
- you are allergic to any ingredient in voriconazole tablets
- you have galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption
- you have untreated low blood calcium, magnesium, or potassium levels
- you are taking astemizole, a barbiturate (eg, phenobarbital), carbamazepine, cisapride, an ergot alkaloid (eg, dihydroergotamine, ergotamine), everolimus, fluconazole, pimozide, quinidine, rifabutin, rifampin, sirolimus, St. John's wort, or terfenadine
Contact your doctor or health care provider right away if any of these apply to you.
Before using voriconazole tablets:
Some medical conditions may interact with voriconazole tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you are allergic to other azole antifungals (eg, fluconazole, itraconazole)
- if you have a history of heart problems (eg, cardiomyopathy, slow or irregular heartbeat); an abnormal electrocardiogram (ECG) (a type of heart test); or low blood calcium, magnesium, or potassium levels
- if you have liver problems (eg, cirrhosis), kidney problems, pancreas problems, a weakened immune system, or a blood disease (eg, blood or bone marrow cancer)
- if you have trouble digesting dairy products or lactose
- if you have ever been on chemotherapy or have had a stem cell transplant
- if you have taken fluconazole within the last 24 hours
- if you are taking efavirenz or ritonavir. Voriconazole tablets should not be taken with certain doses of efavirenz or ritonavir
Some MEDICINES MAY INTERACT with voriconazole tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Medicines that may harm the kidney because the risk of kidney side effects may be increased. Ask your doctor or pharmacist if you are unsure if any of your medicines might affect the kidney
- Medicines that may increase the risk of a certain type of irregular heartbeat (prolonged QT interval). Check with your doctor or pharmacist if you are unsure if any of your medicines may increase the risk of this type of irregular heartbeat
- Many other prescription and nonprescription medicines (eg, used for aches and pains, anxiety, birth control, blood flow problems, blood thinning, cancer, diabetes, drug dependence, heartburn or reflux, high blood pressure, high cholesterol, HIV, immune system suppression, infections, irregular heartbeat or other heart problems, mental or mood problems, pain, seizures, stomach or bowel problems), multivitamin products, or herbal or dietary supplements (eg, herbal teas, coenzyme Q10, garlic, ginseng, ginkgo, St. John's wort) may interact with voriconazole tablets. Ask your doctor or pharmacist if you are unsure if any of your medicines might interact with voriconazole tablets
This may not be a complete list of all interactions that may occur. Ask your health care provider if voriconazole tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use voriconazole tablets:
Use voriconazole tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- An extra patient leaflet is available with voriconazole tablets. Talk to your pharmacist if you have questions about this information.
- Take voriconazole tablets by mouth on an empty stomach at least 1 hour before or 1 hour after eating.
- To clear up your infection completely, take voriconazole tablets for the full course of treatment. Keep taking it even if you feel better in a few days.
- If you miss a dose of voriconazole tablets, take it as soon as possible. It is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use voriconazole tablets.
Important safety information:
- Tell your doctor or dentist that you take voriconazole tablets before you receive any medical or dental care, emergency care, or surgery.
- Voriconazole tablets may cause blurred vision or sensitivity to light. These effects may be worse if you take it with alcohol or certain medicines. Use voriconazole tablets with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Avoid driving at night while you are using voriconazole tablets.
- Voriconazole tablets may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to voriconazole tablets. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
- Certain types of skin cancers (eg, melanoma, squamous cell) have been reported in patients who became sensitive to sunlight while taking voriconazole tablets for a long period of time. Contact your doctor if you notice a change in the appearance of a mole or other unusual skin change or growth. Discuss any questions or concerns with your doctor.
- Voriconazole tablets may make your eyes more sensitive to sunlight. It may help to wear sunglasses. Avoid strong, direct sunlight.
- Serious and sometimes fatal liver problems have happened with voriconazole tablets. Call your doctor right away if you have symptoms of liver problems (eg, dark urine; itching; pale stools; persistent loss of appetite; severe or persistent nausea, vomiting, or stomach pain; yellowing of the skin or eyes).
- A severe skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause serious health problems that may not go away, and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.
- If your symptoms do not improve within a few days or if they become worse, check with your doctor.
- Women who may become pregnant should use effective birth control (eg, birth control pills) while taking voriconazole tablets. Talk with your doctor if you have questions about effective birth control.
- Lab tests, including eye exams, liver and kidney function, and pancreas function, may be performed while you use voriconazole tablets. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Caution is advised when using voriconazole tablets in CHILDREN; they may be more sensitive to its effects, especially sunburn or skin reactions to light.
- PREGNANCY and BREAST-FEEDING: Voriconazole tablets may cause harm to the fetus. Do not become pregnant while you are using it. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using voriconazole tablets while you are pregnant. It is not known if this medicine is found in breast milk. Do not breast-feed while taking voriconazole tablets.
Possible side effects of voriconazole tablets:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Blurred vision; headache; nausea; vomiting.
Severe allergic reactions (rash; hives; itching; difficulty breathing or swallowing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); abnormal thoughts; black, tarry stools; bone pain; calf or leg pain, redness, swelling, or tenderness; change in the appearance of a mole; chest, jaw, or arm pain; confusion; fainting; fast, slow, or irregular heartbeat; fever, chills, or persistent sore throat; flushing; hallucinations; mental or mood changes (eg, depression); mouth sores; one-sided weakness; seizures; severe or persistent dizziness or headache; shortness of breath; speech changes; sudden, severe nausea or vomiting; suicidal thoughts or actions; sunburn or skin reaction to light; swelling of the arms or legs; symptoms of kidney problems (eg, unable to pass urine, change in the amount of urine passed, blood in the urine, big weight gain); symptoms of pancreatitis (eg, severe stomach or back pain, with or without nausea or vomiting); unusual bruising or bleeding; unusual skin change or skin growth; unusual sweating or weakness; unusual tiredness; unusual vaginal bleeding; vision changes (eg, color vision change, persistent or severe blurred vision or sensitivity to light).
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.Proper storage of voriconazole tablets:
Store voriconazole tablets at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Do not refrigerate or freeze. Store away from heat, moisture, and light. Do not store in the bathroom. Keep voriconazole tablets out of the reach of children and away from pets.
- If you have any questions about voriconazole tablets, please talk with your doctor, pharmacist, or other health care provider.
- Voriconazole tablets are to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take voriconazole tablets or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about voriconazole tablets. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to voriconazole tablets. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using voriconazole tablets.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
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- Voriconazole Oral, Intravenous (Advanced Reading)
- Other brands: Vfend