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Venlafaxine Dosage

Applies to the following strength(s): 37.5 mg ; 75 mg ; 25 mg ; 50 mg ; 100 mg ; 150 mg ; 225 mg

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Depression

Immediate release:
Initial dose: 37.5 mg orally twice a day or 25 mg orally 3 times a day
Maintenance dose: May increase in daily increments of up to 75 mg orally at intervals of no less than 4 days
Maximum dose: (moderately depressed outpatients): 225 mg orally per day
Maximum dose (severely depressed inpatients): 375 mg orally per day
Comments:
-Daily dosage may be divided in 2 or 3 doses/day

Extended release:
Initial dose: 75 mg orally once a day
Maintenance dose: May increase in daily increments of up to 75 mg orally at intervals of no less than 4 days
Maximum dose (moderately depressed outpatients): 225 mg orally per day
Maximum dose (severely depressed inpatients): 375 mg orally per day

Use: Treatment of major depressive disorder (MDD)

Usual Adult Dose for Anxiety

Extended release:
Initial dose: 75 mg orally once a day
Maintenance dose: May increase in daily increments of 75 mg orally at intervals of no less than 4 days
Maximum dose: 225 mg orally per day

Uses:
-Treatment of Generalized Anxiety Disorder (GAD)
-Treatment of Social Anxiety Disorder (SAD)

Usual Adult Dose for Panic Disorder

Extended release:
Initial dose: 37.5 mg orally once a day
Maintenance dose: May increase dose in daily increments of 75 mg orally at intervals of no less than 7 days
Maximum dose: 225 mg orally per day

Use: Treatment of Panic Disorder (PD), with or without agoraphobia

Renal Dose Adjustments

-Mild to moderate renal impairment (CrCl 30 to 89 mL/min): Dosage should be reduced by 25% to 50%

Liver Dose Adjustments

-Mild to moderate hepatic impairment: Dosage should be reduced 50%.
-Cirrhosis: Dosage should be reduced by at least 50%.

Dose Adjustments

-Discontinuation: A gradual reduction in the dose is recommended whenever possible. In clinical studies, tapering was achieved by reducing the daily dose by 75 mg at one-week intervals.

Precautions

BOXED WARNING(S):
WARNING: SUICIDAL THOUGHTS AND BEHAVIORS
-Antidepressants increased the risk of suicidal thoughts and behavior in children, adolescents, and young adults in short-term studies. These studies did not show an increase in the risk of suicidal thoughts and behavior with antidepressant use in patients over age 24; there was a reduction in risk with antidepressant use in patients aged 65 and older.
-Patients of all ages who are started on antidepressant therapy should be monitored closely for clinical worsening and emergence of suicidal thoughts and behaviors. Advise families and caregivers of the need for close observation and communication with the prescriber.
-This drug is not approved for use in pediatric patients.

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

-Hemodialysis: Dose should be reduced by at least 50%
-Peritoneal dialysis: Data not available

Other Comments

Administration advice:
-This drug should be administered in a single dose with food, either in the morning or in the evening at approximately the same time each day.
-Each capsule should be swallowed whole with fluid and not divided, crushed, chewed, or placed in water.
-Alternatively, this drug may be administered by carefully opening the capsule and sprinkling the entire contents on a spoonful of applesauce.
-The drug/food mixture should be swallowed immediately without chewing and followed with a glass of water to ensure complete swallowing of the pellets.

General:
-Patients should have their treatment regularly reviewed so as to evaluate the ongoing efficacy of therapy.

Monitoring:
-Psychiatric: Patients should be monitored for discontinuation symptoms, and for worsening and emergence of suicidal thoughts.
-Neurologic: Patients should be monitored for symptoms of serotonin syndrome.
-Cardiovascular: Patients should have regular monitoring of blood pressure.

Patient advice:
-This drug may impair judgment, thinking, and motor skills; therefore, avoid driving or operating machinery if you are affected.

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