Venlafaxine Dosage

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Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Depression

Immediate release:
Initial dose: 37.5 mg orally twice a day or 25 mg orally 3 times a day
Maintenance dose: May increase in daily increments of up to 75 mg at intervals of no less than 4 days
Maximum dose: (moderately depressed outpatients): 225 mg/day
Maximum dose (severely depressed inpatients): 375 mg/day
Daily dosage may be divided in 2 or 3 doses/day

Extended release:
Initial dose: 75 mg orally once daily
Maintenance dose: May increase in daily increments of up to 75 mg at intervals of no less than 4 days
Maximum dose (moderately depressed outpatients): 225 mg/day
Maximum dose (severely depressed inpatients): 375 mg/day

Usual Adult Dose for Anxiety

For generalized anxiety disorder or social anxiety disorder:
Extended release:
Initial dose: 75 mg orally once daily
Maintenance dose: May increase in daily increments of 75 mg at intervals of no less than 4 days
Maximum dose: 225 mg/day

Usual Adult Dose for Panic Disorder

Extended-release:
Initial dose: 37.5 mg once a day
Maintenance dose: May increase dose in daily increments of 75 mg at intervals of no less than 7 days
Maximum dose: 225 mg/day

Renal Dose Adjustments

CrCl 10 to 70 mL/min: Dosage should be reduced by 25% to 50%.
CrCl <10 mL/min: Dosage should be reduced by at least 50%.

Liver Dose Adjustments

Dosage should be reduced by at least 50%.

Dose Adjustments

Discontinuation of venlafaxine:
Tapering of venlafaxine is generally recommended to minimize the risk of adverse symptoms. The period required for tapering is usually dependant on the dose, treatment duration, and the individual patient.

Particular caution is recommended when increasing the dose of venlafaxine in the elderly.

Dialysis

The dose should be withheld until the dialysis treatment is completed (4 hrs) in patients undergoing hemodialysis.

Other Comments

Administer with food.

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