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Timolol Ophthalmic Dosage

Applies to the following strength(s): maleate 0.25% ; maleate 0.5% ; maleate long-acting, 0.5% ; hemihydrate 0.5% ; hemihydrate 0.25%

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Intraocular Hypertension

Solution: One drop of 0.25% solution in the affected eye(s) twice a day
Gel-forming solution: One drop in the affected eye(s) once a day
Long-acting solution: One drop in the affected eye(s) once a day in the morning

Comments:
-Solution: If the clinical response is not appropriate, the dosage may be changed to one drop of 0.5% solution in the affected eye(s) twice a day.
-Solution: If the intraocular pressure is maintained at satisfactory levels, the dosage schedule may be changed to one drop once a day in the affected eye(s).
-If intraocular pressure is still not at a satisfactory level on this regimen, concomitant therapy with pilocarpine and other miotics, and/or epinephrine, and/or systemically administered carbonic anhydrase inhibitors, such as acetazolamide, can be initiated.
-When additional ophthalmic medication is used, an interval of at least 10 minutes between each application is recommended.
-The concomitant use of two topical beta-adrenergic blocking agents is not recommended.
-Intraocular pressure should be reassessed approximately four weeks after starting treatment.

Use: Treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma

Usual Adult Dose for Glaucoma (Open Angle)

Solution: One drop of 0.25% solution in the affected eye(s) twice a day
Gel-forming solution: One drop in the affected eye(s) once a day
Long-acting solution: One drop in the affected eye(s) once a day in the morning

Comments:
-Solution: If the clinical response is not appropriate, the dosage may be changed to one drop of 0.5% solution in the affected eye(s) twice a day.
-Solution: If the intraocular pressure is maintained at satisfactory levels, the dosage schedule may be changed to one drop once a day in the affected eye(s).
-If intraocular pressure is still not at a satisfactory level on this regimen, concomitant therapy with pilocarpine and other miotics, and/or epinephrine, and/or systemically administered carbonic anhydrase inhibitors, such as acetazolamide, can be initiated.
-When additional ophthalmic medication is used, an interval of at least 10 minutes between each application is recommended.
-The concomitant use of two topical beta-adrenergic blocking agents is not recommended.
-Intraocular pressure should be reassessed approximately four weeks after starting treatment.

Use: Treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma

Usual Pediatric Dose for Intraocular Hypertension

<18 years:
Solution:
Initial dose: Instill 1 drop (0.25% solution) in the affected eye(s) twice daily.
Maintenance dose: If response is unsatisfactory, may change to 0.5% solution. If satisfactory response is maintained, may decrease dose to once daily.

Usual Pediatric Dose for Glaucoma (Open Angle)

<18 years:
Solution:
Initial dose: Instill 1 drop (0.25% solution) in the affected eye(s) twice daily.
Maintenance dose: If response is unsatisfactory, may change to 0.5% solution. If satisfactory response is maintained, may decrease dose to once daily.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Patient advice:
-Patients should be instructed to wash their hands before use and avoid allowing the tip of the bottle to come into contact with the eye or surrounding structures.
-Systemic absorption of drugs from ophthalmic solutions may be minimized by
pressure on the tear-duct immediately after application.

Storage requirements:
-Protect from light
-Do not freeze
-Do not store above 25 C (77 F)

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