Timolol Ophthalmic Dosage

This dosage information may not include all the information needed to use Timolol Ophthalmic safely and effectively. See additional information for Timolol Ophthalmic.

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Intraocular Hypertension

Solution:
Initial dose: Instill 1 drop (0.25% solution) in the affected eye(s) twice daily.
Maintenance dose: If response is unsatisfactory, may change to 0.5% solution. If satisfactory response is maintained, may decrease dose to once daily.

Long-acting solution (Istalol(TM)):
Initial dose: Instill 1 drop in the affected eye(s) once daily. If response is unsatisfactory, other pressure-lowering agents (non-beta blockers) may be added.

Gel-forming solution:
Instill 1 drop in the affected eye(s) once daily. Invert the container and shake once before administration.

Usual Adult Dose for Glaucoma (Open Angle)

Solution:
Initial dose: Instill 1 drop (0.25% solution) in the affected eye(s) twice daily.
Maintenance dose: If response is unsatisfactory, may change to 0.5% solution. If satisfactory response is maintained, may decrease dose to once daily.

Long-acting solution (Istalol(TM)):
Initial dose: Instill 1 drop in the affected eye(s) once daily. If response is unsatisfactory, other pressure-lowering agents (non-beta blockers) may be added.

Gel-forming solution:
Instill 1 drop in the affected eye(s) once daily. Invert the container and shake once before administration.

Usual Pediatric Dose for Intraocular Hypertension

<18 years:
Solution:
Initial dose: Instill 1 drop (0.25% solution) in the affected eye(s) twice daily.
Maintenance dose: If response is unsatisfactory, may change to 0.5% solution. If satisfactory response is maintained, may decrease dose to once daily.

Usual Pediatric Dose for Glaucoma (Open Angle)

<18 years:
Solution:
Initial dose: Instill 1 drop (0.25% solution) in the affected eye(s) twice daily.
Maintenance dose: If response is unsatisfactory, may change to 0.5% solution. If satisfactory response is maintained, may decrease dose to once daily.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

Systemic absorption may occur after topical administration and the same adverse effects found with systemic administration may be seen following ophthalmic use.

In the advent of an anaphylactic reaction, patients may be less responsive to usual doses of epinephrine.

Betaxolol ophthalmic should be used with caution, if at all, in patients with angle-closure glaucoma, cardiac disease (i.e., bradycardia, AV block, cardiogenic shock, overt heart failure), cerebrovascular insufficiency, diabetes mellitus, myasthenia gravis, pulmonary disease (i.e., asthma, bronchospasm, COPD), surgical anesthesia, and thyrotoxicosis.

Safety and efficacy (i.e., intraocular pressure lowering effects) have been demonstrated in pediatric patients.

Dialysis

Since timolol is not significantly removed by hemodialysis, supplemental dosing after dialysis is not necessary. Although very little timolol topical ophthalmic solution is systemically absorbed, there are reports of significant bradycardia and hypotension after use of timolol eye drops. Therefore, it is recommended that timolol be administered at some time after hemodialysis when the patient is hemodynamically stable.

Other Comments

To prevent systemic absorption, the conjunctival sac should be compressed by digital pressure for 1-3 minutes after administration.

Remove contact lenses before administration and wait 15 minutes before reinserting them.

If other eyedrops are used, they should be instilled at least 10 minutes apart.

Patients should be instructed to avoid allowing the tip of ophthalmic containers to contact the eye, eyelid, fingers or any other surface.

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